Sanjeev Thohan Email and Phone Number
San Diego, CA, US
Sanjeev Thohan's Location
San Diego, California, United States, United States
Sanjeev Thohan's Contact Details
Sanjeev Thohan work email
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About Sanjeev Thohan
Sanjeev Thohan is a highly motivated research scientist who with every move has sought new challenges to overcome. He holds MS and PhD degrees in Pharmacology and Toxicology with concentrations in drug metabolism mechanisms, bioactivation pathways, and systems toxicology. He has actively contributed to: preparation of Pre-IND/IND, NDA and proof of concept documentation to support regulatory filings as preclinical development continues; inter-species scaling and projection of FIM dosage algorithm development; metabolic pathway elucidation and structural (SAR) feedback to medicinal chemistry for additional iterations based on biological data streams; high throughput bioanalytical method development/transfer, as well as troubleshooting for rapid method development/implementation. He has also led teams for evaluation of strategic critical pathway development, implementation and execution to provide data front-loading and reduction in time to IND. He is a highly motivated research scientist who has worked at Walter Reed Army Institute for Research, Covance Laboratories, AstraZeneca, Viropharma, Exelixis and as the founder of SARx Consulting it Novartis (NIBR), Xeris Pharmaceuticals, Kinnate Biopharma and is currently SARx consulting in San Diego assuring and mentoring startups. Sanjeev’s track record includes advancement of 42 small molecule compounds through discovery to IND and various stages of active clinical development since 1997 with 7 of these progressing to NDA/Market. Therapeutic areas in which he has been actively involved are oncology, cardiovascular, metabolic diseases and antimicrobial, as well as antiviral therapeutics.Sanjeev continues to be a contributing member of several national/international scientific societies. He is a very active speaker with local and national scientific groups regarding preclinical safety/Mechanistic Toxicology, ADME-PKPD relationships and translational sciences. He actively serves on the advisory boards for several startups and is involved in mentoring new startups and investigators to seed the next generation for growth.
Sanjeev Thohan's Current Company Details
Sanjeev Thohan Work Experience Details
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Chief Scientific OfficerArise Biopharma IncSan Diego, Ca, Us
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Chief Scientific OfficerLatentspace Therapeutics Jul 2024 - PresentKeep an Eye out for us - Stealth Mode for now
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Founder Sarx ConsultingSarx Consulting Feb 2023 - PresentIf you know of companies in or out of your portfolio who may benefit from a seasoned small molecules consultant. I’m launching my consulting efforts for a constellation of Nonclinical activities (SARx consulting) from late Lead Optimization, ADME PK modeling, TOX and studies to enable IND to end of Phase I meetings with the regulatory agencies. SME due diligence directionality for portfolio optimization and buy-sell side preparation. Thanks. Sanjeev Sarxconsult@gmail.com415-971-2327
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Founder/Managing PartnerSarx Consulting Jan 2009 - PresentSARx is a preclinical Toxicology consulting organization that provides:Primary DMPK/Toxicology expertise on lead validation, optimization, and candidate selection.Preparation of Pre-IND/IND and proof of concept documentation to support regulatory documents as preclinical development continues. Interspecies scaling and projection of FIM dosage algorithm development.Metabolic pathway elucidation and feedback to medicinal chemistry for additional iterations.High Throughput Bioanalytical method development/transfer as well as troubleshooting.Feel free to contact me for more information. SARxConsult@Gmail.com
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Scientific Advisory Board MemberPhoenix Molecular Designs Jan 2019 - PresentSan Diego, California, UsI am delighted to be working with Sandi and the excellent team at Phoenix Molecular Designs. I wholeheartedly share the vision for “We will attack the problem of developing advanced breast cancer therapeutics by leveraging novel IP and a team with global experience in problem solving”Our work focuses on developing novel drugs around kinases, specifically p90 ribosomal S6 kinases (RSK), which we have led the field in establishing as a molecular target for cancer.Our focus is on treating one of the most aggressive types of breast cancer, Triple Negative Breast Cancer (TNBC), which currently does not have any approved targeted treatments. Our patented cancer compounds position us in the lead to fast track our product to market as it fills an unmet medical need as an effective, safer treatment for a serious medical condition. Our cancer therapy will potentially save lives and improve the lives of cancer patients.http://phoenixmd.ca/ -
Scientific Advisory Board MemberCogentis Therapeutics, Inc. Jan 2017 - PresentBaltimore, Maryland, UsI have had the great pleasure of working with Kent Werner and the team at Cogentis with the Neurostartup Challenge series of innovation contests sponsored by the center for advancing innovation with Rosemarie Truman (https://www.thecenterforadvancinginnovation.org/). Cogentis has an incredibly motivated team and we are working on a very challenging problem in Alzheimers and Neurodegenerative diseases.We want to cure the most debilitating of neurodegenerative disorders - Alzheimer's disease, fronto-temporal dementia (FTD), progressive supranuclear palsy (PSP), Parkinson's disease and more. We imagine a world where our research leads to breakthrough treatments so that no one has to suffer from dementia again. -
MentorThe Center For Advancing Innovation Inc. Jun 2015 - PresentBethesda, Maryland, UsNeurostart-up challenge mentor (Alzheimer's Parkinson's disease therapy Start-ups)The Center for Advancing Innovation and the National Institutes of Health's National Cancer Institute have partnered to launch the Nanotechnology Startup Challenges in a variety of therapeutic areas. This Challenge features inventions conceived and developed by scientists at the National Institutes of Health and is also open to teams that bring other promising technologies. The mentor's guide their teams through the various phases of the Nano-startup program (http://www.nscsquared.org) in helping them to curate and grow their virtual company to actualization with funding with Commercialization planning, R&D road-maps, IP strategy, Regulatory Strategy, Financial/Commercial Strategy -
Advisory Board MemberVarshyltech Jan 2010 - Nov 2023Advisor to the CEO/Founders at Varsyltech.comVarshyl Tech is among the leading companies in Website Design and Development in India. and are pioneers in iphone/ipad application development with custom solution for publishing industry.Key services in the space of web provided by us include website design, website development, website maintenance, search engine optimization, search marketing, content management, and offshore software development.And in mobile space we provide services for ipad apps, ipad ready magazines, iphone apps development, iphone game development.Our solutions are results-oriented website design and development, ipad and iphone application development, search engine marketing/optimization. Conceive and Co-Create (our DNA) help us in better business understanding, UI and Development and that shows in our impressive list of clients that includes LG, Hindustan Times, Govt of Mizoram.
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Vice President Nonclinical DevelopmentKinnate Biopharma, Inc. Mar 2020 - Feb 2023San Diego, California, UsKinnate Biopharma is a biopharmaceutical company advancing a pipeline of precision oncology therapeutics to treat patients with genomically defined vulnerabilities.Leading a team of like-minded motivated individuals to enable mission critical decisions for these novel Oncology therapeutics. Determine go-no go at each stage of assessment with a judicious use of selective elimination criteria from ADME, DMPK and TOX data streams. Optimization of preclinical plans to accelerate clinical timelines. -
Senior Director Preclinical SafetyXeris Pharmaceuticals, Inc. Oct 2017 - Mar 2020Chicago, Illinois, UsADME, DMPK and TOX Program development and management for all aspects of IND and NDA preparation. Optimization of preclinical plans to accelerate Clinical timelines for registration. Subject matter expert for pharmacology and toxicology activities in preclinical optimization and candidate preparation as well as due diligence activities. Work closely with internal research personnel and provide a key interface between research and development as well as close interaction with the R&D team to identify new indications and drug product concepts. -
Research Fellow Toxicology/Translational SciencesNovartis Aug 2009 - Oct 2017Basel, Baselstadt, ChResearch Fellow in Preclinical Safety (Toxicology)/Translational Sciences at the Novartis Institutes of Biomedical Research in Cambridge, MA.Program development and management for all aspects of IND preparation through to the clinic for oncology, cardiovascular/metabolism, infectious diseases and antiviral therapeutic areas.Small moelcule and antbody-drug conjugate (ADC) experienceMission critical decisions determine go-no go at each stage of assessment – judicious use of selective elimination criteria.Subject matter expert for Toxicology and Pharmacology activities in preclinical optimization and candidate preparation for clinical investigations.Due diligence execution consulting services for investment M&A activities. -
Advisory Board Member/Angel InvestorSizemob Nov 2011 - Dec 2015Early stage investor and member of the Board of Directors. Helped Sizemob.com build a first of its kind web platform for integrated sharing for a new shopping experience. The company has successfully created * An easy to use App on Facebook and Mobile Devices * Private 1-to-1 sharing of your personal brands and sizes * Simple size sharing of only clothing sizes, only with people you want.Worked with the founders to launch and create brand awareness and deep-sustainable market penetration. Aggregate additional capital investors and enable an effective monetization model for Sizemob.com.http://www.fashionotes.com/content/2012/10/fninsider-vagish-kapila-from-sizemob/
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Founder/Corporate Operations/Creative DirectorTapsmack.Com Jan 2008 - Dec 2015San Jose, Ca, UsTapSmack’s platform is a unique collaborative commerce technology in a global community to appeal to “Generation C or Prosumers” that includes casual browsers to professionals and enterprise based members. Our recent successes with non-profit groups has demonstrated the power of TapSmack as a marketing platform that is powered by the co-creative efforts of contributors for their favorite charity. Revenue sharing is a BIG component of the attraction to our site. Your ideas can and do net you real cash as well as "SmackCash" to buy kewl things from the "Smack-Store" We have had requests for Music mash-ups, architectural, design elements for decoration, as well as construction, so you can imagine the possibilities of co-creation. Imagine an eBay where existing products are not merely bought and sold, but are created by the network with a pre-existing following. TapSmack’s platform enables the individual to create and explore his/her own identity, creating their own very personal brand. Their visit does not include just buying, as that they can do anywhere. What we offer is personalization on a web-scale. As a response to our user-base we've recently added a music co-creation component to our platform, so If you're musically inclined or just want to listen to some cool beats, come on by.,.... see and share -
Research Director Dmpk/Toxicology Preclinical DevelopmentExelixis May 2004 - Jan 2009Alameda, California, UsProvide primary DMPK/Toxicology expertise on therapeutic area project teams for lead validation, optimization, and candidate selection.Preparation of Pre-IND/proof of concept documentation to support regulatory documents as preclinical development continues. Interspecies scaling and projection of FIM dosage.Establish and implement high throughput assays for in vitro drug discovery support for novel compounds in Oncology, Cardiovascular, and Metabolism therapeutic areas.Implementation of robotic automation for sample preparation, cassette analysis, and improved chromatographic resolution to enhance throughput.Metabolic pathway elucidation and feedback to medicinal chemistry for additional iterations.Building productive and effective teams, scientific leadership, and development of all levels of staff. -
Group Leader DmpkViropharma Inc Aug 2002 - May 2004UsProvide DMPK expertise on therapeutic area project teams for lead development and candidate selection.Preparation of IND section for Pharm/Tox and other supporting regulatory documents. Key laboratory role/presence for method development and implementation. Establish and grow in vivo and in vitro drug discovery support for novel compounds for anti-viral therapeutic areas.Establish In vitro screening and characterization of CYP-450-based drug interactions. High throughput assay development using fluorescence plate reader, LC-UV and LCMS-based methodology. Metabolic pathway elucidation and quantitation using LC-MS/MS-based analysis Scientific leadership and development of junior staff. -
Senior ScientistAstra Zeneca Pharmaceuticals May 2001 - Aug 2002Provide DMPK expertise on therapeutic area project teams for lead development and candidate selection.Key laboratory role/presence for method development and implementation.Establish and grow in vivo and in vitro drug discovery support for novel compounds in the cancer and infectious disease therapeutic areas.Establish and support In vitro drug metabolism screening and disposition studies using hepatic microsomes and cryopreserved hepatocytes and in-house prepared primary hepatocytes.Establish In vitro screening and characterization of CYP-450-based drug interactions.Metabolic pathway elucidation and quantitation using LC-MS/MS-based analysis High throughput assay development using fluorescence plate reader, LC-UV and LC/MS-based methodology.Development and implementation of high throughput analytical systems in support of drug discovery efforts.Troubleshoot and maintain instrumentation.Scientific leadership and development of junior staff.
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Study DirectorCovance Laboratories 1997 - 2001Support Drug Discovery and Development programs for large and small pharmaceutical companies.Assessment of Phase I and Phase II integrated metabolism using in vivo and in vitro study designs.High throughput assay development using fluorescence plate reader, LC-UV and LC/MS-based methodology.Protein binding studies for support of GLP and non-GLP studies. Prepare IND and NDA-ready GLP documents for FDA submission.Consultant in drug metabolism and disposition for new chemical entities.Laboratory-based staff training in various in vitro and in vivo techniques for the study of drug metabolism and disposition.Project management, development and implementation of marketing plans for strategic business growth.
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Consulting Laboratory Research DirectorWalter Reed Army Institute Of Research Jan 1993 - Jan 1998Silver Spring, Maryland, UsConsulting Laboratory research director for the development of liver slice technology in metabolic and toxicological studies.In vitro safety assessment of drug candidates for infectious/tropical diseases.Mechanistic toxicology studies. -
Clinical ToxicologistJohns Hopkins Medicine Sep 1993 - Jun 1997Baltimore, Md, UsClinical Chemist and Clinical Toxicologist supporting the ER
Sanjeev Thohan Skills
Drug Discovery
Drug Development
Biotechnology
Clinical Development
Pharmacology
Pharmaceutical Industry
Toxicology
Oncology
Pharmacokinetics
In Vivo
Assay Development
Cro
In Vitro
Glp
Laboratory
Lifesciences
Translational Medicine
Ind
Fda
Chemistry
Cell Culture
Drug Metabolism
Translational Research
Validation
Dmpk
Cancer
Adme
Medicinal Chemistry
Lead Change
Biopharmaceuticals
Infectious Diseases
Bioanalysis
Protein Chemistry
Biomarkers
Pk/pd
Pharmaceutics
Chromatography
Clinical Study Design
Drug Delivery
Small Molecules
Biomarker Discovery
Translational Toxicology
Innovation Management
Innovation Development
Enzyme Kinetics
Medical Devices
Creative Vision
Angel Investing
Due Dilligence Assessment
Disruptive Technologies
Sanjeev Thohan Education Details
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University Of Maryland BaltimorePharmacology And Toxicology/ Pharmaceutical Sciences -
University Of ArizonaPharmacology And Toxicology
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Towson UniversityMolecular Biology/Anatomy & Physiology
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Baltimore Polytechnic InstituteScience Track
Frequently Asked Questions about Sanjeev Thohan
What company does Sanjeev Thohan work for?
Sanjeev Thohan works for Arise Biopharma Inc
What is Sanjeev Thohan's role at the current company?
Sanjeev Thohan's current role is Chief Scientific Officer.
What is Sanjeev Thohan's email address?
Sanjeev Thohan's email address is sa****@****ate.com
What is Sanjeev Thohan's direct phone number?
Sanjeev Thohan's direct phone number is (862)-778*****
What schools did Sanjeev Thohan attend?
Sanjeev Thohan attended University Of Maryland Baltimore, University Of Arizona, Towson University, Baltimore Polytechnic Institute.
What are some of Sanjeev Thohan's interests?
Sanjeev Thohan has interest in Scientific Knowledge Based Discussions.
What skills is Sanjeev Thohan known for?
Sanjeev Thohan has skills like Drug Discovery, Drug Development, Biotechnology, Clinical Development, Pharmacology, Pharmaceutical Industry, Toxicology, Oncology, Pharmacokinetics, In Vivo, Assay Development, Cro.
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