Santosh Kurhade (Ph.D.) Email & Phone Number

Hyderabad, Telangana, India

Bengaluru, Karnataka, India

Bangalore

Groningen Area, Netherlands

• Design, synthesis and validation of potent and isozyme selective arginase inhibitors for therapeutic use in asthma.
• Multicomponent reactions (MCR) based designed and synthesis novel compound.
• Develop and understand the structure-activity relationship (SAR) for potency and isozyme selectivity.
• Design and synthesis of positron emission tomography (PET) precursor for the cell-based study and understand the compound distribution in-vivo.
• Synthetic route evaluation and scale-up synthesis for in-vivo studies.
• Regularly updated the progress and given the scientific presentation to the lab members.

Pune Area, India

• Chemistry team member for Advinus- Takeda pharma collaborative project.
• Lead the team of 4-chemists for pyruvate dehydrogenase kinase 4 ( PDK4 ) program.
• Design and synthesis novel inhibitors.
• Structure-activity relationship was developed for potency, CYP, and hERG
• Synthetic route evaluation and scale-up synthesis for key intermediates.
• Regularly updated the progress and given a scientific presentation to the team members.

Pune Area, India

• Bruton’s tyrosine kinase (BTK) inhibitor project for the treatment of rheumatoid arthritis (RA).
• Contributed in design and synthesized novel ‘’azaindole’’ based series for BTK project.
• SAR was develop to understand the SAR for potency and metabolic stability.
• Optimized the synthetic route for scale-up synthesis.
• Regularly updated the progress and given a scientific presentation to the team members.
• Helped in writing the patent drafts, analysis, claim to understand.

Pune Area, India

• Glucokinase (GK) activator project for Type-II diabetes.
• Contributed in design and synthesis novel scaffold for GK project.
• Structure-activity relationship (SAR) was developed for the potency and correlated with in-vivo efficacy.
• Optimized the synthetic route for scale-up synthesis.
• Helped in writing the patent drafts, analysis, claim to understand.
• Compound progressed in phase-II clinical studies

Pune Area, India

• GPR91 antagonist project for hypertension.
• Contributed in design and synthesis of novel chemical entities for the project.
• Developed the SAR for potency and helped in solving the Aq. solubility issues.
• Optimized the synthetic route for scale-up synthesis.
• Work has been published in Bioorganic & Medicinal Chemistry Letters 21 (2011) 3596.

Gurgaon, India

• I was involved macrolide (ketolides) antibiotics project.
• Contributed in design and synthesis of novel ketolide carbamate and carbazate series.
• Synthesized around 200 novel chemical entities for the project.
• Optimized the electrophilic fluorination reaction on the macrolide scaffold.
• Optimized the synthetic route for scale-up synthesis of Telithromycin (Ketak®).
• Co-inventor of 4-PCT applications from this project

Bachelor'S Degree, Chemistry

Master'S Degree, Drug Chemistry

Phd-Student, Medicinal And Pharmaceutical Chemistry