Shamini Ayyadhury Email & Phone Number

Toronto, On, Ca

Toronto, On, Ca

Panoramics offers a vision for a pan-Canadian collaborative working cluster for spatial and single cell multi-omics technologies & projects. Panoramics promotes dialogues that will inspire, challenge and enlighten the scientist in you. Here, open dialogues are encouraged, where groundbreaking positive and negative data are shared and discussed. Panoramics encourages tutorials that will challenge you to think beyond your comfort zone. Through these dialogues and interactions, we aim to educate and encourage collaborations that will push the boundaries of the spatial and single cell world.​Together, we can re-imagine the way conversations between scientists take place, and build a panorama that goes beyond our collective imaginations.

Toronto, Ontario, Canada

Toronto, Ontario, Canada

As creative director, I was part of designing and creating marketing and promotional materials as well as establishing novel steam-orientated educational materials for children.

Montreal, Quebec, Canada

My research included the identification of hierarchical model in GBM and the pre-clinical therapeutic evaluation of anti-sense compounds using in-vivo GBM models. During the course of my research, I introduced, optimized and implemented techniques for pre-clinical drug evaluation (intracerebroventricular injection, osmotic pump mediated drug delivery, optimization of precision injections in niche brain regions and dose-response evaluation), CRISPR-mediated gene editing, multiplex-immunolabelling of patient-derived and xenograft tissues, single-cell mass cytometry and single cell RNA sequencing. Furthermore, I introduced and implemented computational analysis of images and mass cytometry. My other responsibilities included training junior scientists and technicians on these techniques.

Singapore

I was part of the lab management team and provided extensive lab support through the collation and management of SLAS (Singapore Longitudinal Aging Study) samples. This involved PBMC isolation from fresh blood collected daily from elderly recruits and the subsequent multi-parametric (16-color) flow cytometry analysis in understanding T-cell diversity and changes with age. In addition, I was responsible for the management of blood samples from asthma patients obtained from the ICU and for profiling the whole blood using flow cytometry.

Singapore

The primary objectives of my role were to maintain professional standards of product development by acting as a liason between the Product and Research Development and the Marketing departments. My responsibilities involved international travel to meet with researchers and potential manufacturing investors from the USA, Russia, Malaysia, Sri Lanka and Germany and conducting training sessions for Business Associates on product knowledge and working with doctors, researchers and service providers to continuously improvise existing products and services.

Singapore

As a research officer, I worked on a series of drug-treatment assays in collaboration with Eli Lilly. The aim of this collaboration was to compare the different EC50 values of various drugs within and between cell-lines and to compare the differential efficacies of these drugs between CD133+ and CD133-cells. CD133+ cells have been postulated to hold a sub-population of rare cancer stem cells (CSCs) which have been implicated in conferring resistance to cancer cells via their capacity to survive and in expanding a cellular hierarchy of cancer cells. I worked on additional projects which included evaluating the effects of a “histone-modifier inhibitor” on cancer stem cells and in conducting drug-dosage response studies to screen for potential cancer stem cell death-inducing drug.

Singapore, Singapore

Singapore

I was in charge of establishing a stable cell line using TNF knock-out fibroblasts from mice and murine neuronal stem cells and to use this cell-line, once established, to induce receptor activation via an agonist antibody and for subsequent intracellular signaling studies. The aim was to establish a tripletransfected cell system [APP/mPs1/mPS2] using a PC12 tet-on cell line to derive an inducible cell death system for potential anti-apoptotic studies as potential therapeutic targets for AD. Furthermore, I was also responsible for lab management and administrative duties.

Doctor Of Philosophy - Phd, Neuroscience

Master'S Degree, Neuroscience

Bachelor Of Science - Bs, Life Sciences

Activities and Societies: Tamil Language Society (Publications Secretary) Sangae 2003 (Yearly major drama production.