Brian Schmidt

Brian Schmidt Email and Phone Number

Executive Director, Clinical Pharmacology at Madrigal Pharmaceuticals @ Madrigal Pharmaceuticals
Brian Schmidt's Location
Princeton, New Jersey, United States, United States
Brian Schmidt's Contact Details

Brian Schmidt personal email

n/a
About Brian Schmidt

Brian Schmidt is a Executive Director, Clinical Pharmacology at Madrigal Pharmaceuticals at Madrigal Pharmaceuticals. He possess expertise in systems biology, biotechnology, assay development, biomedical engineering, cell culture and 13 more skills. Colleagues describe him as "Brian was a key engineer on a multi-month project, for a difficult client, using the Entelos CV PhysioLab which I designed. I have been working in the cardiovascular disease area for literally dozens of years and Brian is easily one of the most enthusiastic, dedicated and intellectually curious 'non-biologists' I have worked with. Not only was Brian asking very acute and apposite questions 24 hours a day (almost literally) he was always a responsive and excellent communicator in regards to his results and findings during the project. Brian is unwaveringly calm and resilient in the face of looming deadlines and changes in schedule. The team had occasion to use his skills to literally "blind the client with science" a couple of times, which I found particularly enjoyable to watch. I appreciated not only Brian's technical skills but also his wry sense of humor and the fact that he willingly undertook every task no matter how small/large trivial or complex. I would dearly welcome the opportunity to work with Brian again.", "I was part of the team that hired Brian at Entelos Inc and I trained and worked with him on a client research project over a period of 4 months upon his joining the company. I was impressed by the speed at which Brian learned a very complex computational disease model, and his ability to assume the engineering/technical leadership on a client research project so soon after completing his PhD and joining the company. He is extremely dedicated, investing whatever effort is needed to achieve project goals, and is both bright and innovative in his approaches to problem-solving. He takes the initiative to learn new areas related to his work (e.g., independently studying immunology and rheumatology texts and literature for the project we worked on together). In addition to his excellent performance, I would also say Brian is one of the most pleasant, courteous and universally liked individuals I have had the pleasure to interact with.", and "Brians worked in my lab for only a few months, but he performed exceptionally well and he was very productive for the time he was there. Brian is a meticulous and highly inquisitive scientist."

Brian Schmidt's Current Company Details
Madrigal Pharmaceuticals

Madrigal Pharmaceuticals

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Executive Director, Clinical Pharmacology at Madrigal Pharmaceuticals
Brian Schmidt Work Experience Details
  • Madrigal Pharmaceuticals
    Executive Director, Clinical Pharmacology
    Madrigal Pharmaceuticals Nov 2024 - Present
    Conshohocken, Pennsylvania, Us
  • Bristol Myers Squibb
    Executive Director, Head Quantitative Systems Pharmacology & Physiologically Based Pharmacokinetics
    Bristol Myers Squibb May 2022 - Nov 2024
    Lawrence Township, Nj, Us
    • Lead and manage a team of about 30 scientists to broadly inform and impact activities from research through clinical development across the portfolio applying mechanistic modeling strategies.• Clinical Pharmacology, Pharmacometrics, and Bioanalysis department Senior Leadership Team member
  • Bristol Myers Squibb
    Senior Director, Head Quantitative Systems Pharmacology & Physiologically Based Pharmacokinetics
    Bristol Myers Squibb Jan 2021 - May 2022
    Lawrence Township, Nj, Us
  • Bristol Myers Squibb
    Director / Research Fellow (Quantitative Systems Pharmacology)
    Bristol Myers Squibb Jul 2019 - Jan 2021
    Lawrence Township, Nj, Us
    • Quantitative Clinical Pharmacology group member within Clinical Pharmacology and Pharmacometrics• Lead for QSP efforts and a small group in the oncology/immuno-oncology therapeutic area
  • Bristol Myers Squibb
    Associate Director / Senior Principal Scientist (Quantitative Systems Pharmacology)
    Bristol Myers Squibb Mar 2016 - Jul 2019
    Lawrence Township, Nj, Us
    • Quantitative Clinical Pharmacology group member within Clinical Pharmacology and Pharmacometrics• Lead for QSP efforts and a small group in the oncology/immuno-oncology therapeutic area
  • Bristol Myers Squibb
    Senior Research Investigator (Quantitative Systems Pharmacology)
    Bristol Myers Squibb Mar 2014 - Mar 2016
    Lawrence Township, Nj, Us
    • Quantitative Clinical Pharmacology group member within Clinical Pharmacology and Pharmacometrics• Apply Quantitative Systems Pharmacology models and approaches to advance small molecules and biologics from preclinical research through clinical trials with a focus on oncology and immuno-oncology therapeutic areas• Manage platform development projects• Develop QSP tools, workflows, and algorithms
  • Sanford-Burnham Medical Research Institute
    Postdoctoral Associate (Computational Biology)
    Sanford-Burnham Medical Research Institute 2013 - 2014
    La Jolla, Ca, Us
    • Dr. Sumit K. Chanda's Lab, Infectious and Inflammatory Disease Center• Lead the integration of multi-omics data sources (RNA-seq, RNAi screens, APMS) using network-based approaches to interpret results and propose follow-up experiments for high-confidence targets to elucidate drug targets and host factors that restrict viral replication and impact disease outcomes
  • Uc San Diego
    Postdoctoral Scholar (Systems Biology)
    Uc San Diego 2011 - 2013
    La Jolla, Ca, Us
    • Dr. Bernhard Ø. Palsson's Systems Biology Research Group, Bioengineering Department• Developed algorithms and employed genome-scale mathematical models of cellular metabolism constructed from annotated genomes to guide the functional, integrated interpretation of microarray (oligonucleotide), proteomic (LC-MS/MS), and metabolomic (GC-MS) samples to develop insights into the adaptive responses of bacterial pathogens in host-mimicking environments• Communicated with pathogen experts and omics cores across sites to refine analyses, develop recommendations for follow-up experiments, and contribute to manuscript preparation for publication in peer-reviewed journals• Wrote research plans for grant and fellowship applications
  • Entelos
    Dynamics Engineer (Quantitative Systems Pharmacology)
    Entelos 2009 - 2011
    • Performed research with mechanistic computational models of human disease pathophysiology in multiple therapeutic areas, including rheumatoid arthritis, cardiovascular disease, and type 2 diabetes• Developed mathematical representations for novel therapeutics and new biology, developed predictions of clinical efficacy, optimized PK/PD parameters, and performed sensitivity analysis to identify the pathways most important for efficacy• Performed statistical population-level research with virtual patient cohorts to optimize clinical trial design and identify multianalyte biomarkers of clinical efficacy • Lead meetings to present research results and make recommendations to scientists in pharmaceutical research and development groups• Scoped new research projects, developed project timelines, and lead research projects
  • University Of Virginia
    Postdoctoral Research Associate (Systems Biology)
    University Of Virginia 2009 - 2009
    Charlottesville, Va, Us
    • Dr. Jason Papin's Computational Systems Biology Lab, Department of Biomedical Engineering• Employed partial least squares regression and support vector machine learning classification on reverse phase phosphoprotein array data from cancer cell lines to develop predictors of metastasis, growth, and response to chemotherapeutics• Utilized expression microarray data to adapt a linear genome-scale model (H. sapiens Recon 1) to represent a murine cardiomyocyte-specific model of metabolic function in health and diabetes
  • University Of Virginia
    Graduate Research Assistant
    University Of Virginia 2003 - 2009
    Charlottesville, Va, Us
    • Dr. Michael B. Lawrence's Lab, Department of Biomedical Engineering• Developed computational models, tracking algorithms, molecular biology methods, and new assays to elucidate molecular characteristics that govern leukocyte adhesion biophysics under vascular shear flow
  • Philips Research Europe
    Research Extern
    Philips Research Europe Jun 2006 - Aug 2006
    Amsterdam, Noord-Holland, Nl
    • Designed and tested a novel acoustic flow system and characterized the acoustic and adhesive properties of monodisperse, polymer-shelled microbubbles being developed for ultrasound contrast and drug delivery
  • Whatman Hemasure
    Quality Engineer
    Whatman Hemasure 2002 - 2002
    • Quality Engineer at an ISO 9001:1994 certified and 21CFR820 regulated manufacturer of leukoreduction systems
  • Bayer
    Engineering Co-Op
    Bayer 1999 - 2001
    Leverkusen, North Rhine-Westphalia, De
    • Worked on four, three-month internships in process, project, and production engineering groups in both the chemical and biopharmaceutical industries

Brian Schmidt Skills

Systems Biology Biotechnology Assay Development Biomedical Engineering Cell Culture Matlab R Immunology Mathematical Modeling Computational Biology R&d Biochemistry Data Analysis Bioinformatics Oncology Drug Development Quantitative Systems Pharmacology Python

Brian Schmidt Education Details

  • University Of Virginia
    University Of Virginia
    Biomedical Engineering
  • University Of Pittsburgh
    University Of Pittsburgh
    Chemical Engineering

Frequently Asked Questions about Brian Schmidt

What company does Brian Schmidt work for?

Brian Schmidt works for Madrigal Pharmaceuticals

What is Brian Schmidt's role at the current company?

Brian Schmidt's current role is Executive Director, Clinical Pharmacology at Madrigal Pharmaceuticals.

What is Brian Schmidt's email address?

Brian Schmidt's email address is bj****@****nia.edu

What schools did Brian Schmidt attend?

Brian Schmidt attended University Of Virginia, University Of Pittsburgh.

What skills is Brian Schmidt known for?

Brian Schmidt has skills like Systems Biology, Biotechnology, Assay Development, Biomedical Engineering, Cell Culture, Matlab, R, Immunology, Mathematical Modeling, Computational Biology, R&d, Biochemistry.

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