Executive Director, Clinical Pharmacology
Current
Nov 2024 - Present
AeroLeads people directory · profile
Brian Schmidt Email & Phone Number
Executive Director, Clinical Pharmacology
at
Madrigal Pharmaceuticals
1 work email found
@bms.com
LinkedIn matched
✓ Verified Jul 2026
4 data sources
Profile completeness 100%
Current company
Role
Executive Director, Clinical Pharmacology
Location
Princeton, New Jersey, United States
Who is Brian Schmidt? Overview
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Quick answer
Brian Schmidt is listed as Executive Director, Clinical Pharmacology at Madrigal Pharmaceuticals, based in Princeton, New Jersey, United States. AeroLeads shows a work email signal at bms.com and a matched LinkedIn profile for Brian Schmidt.
Brian Schmidt previously worked as Executive Director, Head Quantitative Systems Pharmacology & Physiologically Based Pharmacokinetics at Bristol Myers Squibb and Senior Director, Head Quantitative Systems Pharmacology & Physiologically Based Pharmacokinetics at Bristol Myers Squibb. Brian Schmidt holds Phd, Biomedical Engineering from University Of Virginia.
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{first}.{last}@bms.com
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Profile bio
About Brian Schmidt
Brian Schmidt is a Executive Director, Clinical Pharmacology at Madrigal Pharmaceuticals. He possess expertise in systems biology, biotechnology, assay development, biomedical engineering, cell culture and 13 more skills. Colleagues describe him as "Brian was a key engineer on a multi-month project, for a difficult client, using the Entelos CV PhysioLab which I designed. I have been working in the cardiovascular disease area for literally dozens of years and Brian is easily one of the most enthusiastic, dedicated and intellectually curious 'non-biologists' I have worked with. Not only was Brian asking very acute and apposite questions 24 hours a day (almost literally) he was always a responsive and excellent communicator in regards to his results and findings during the project. Brian is unwaveringly calm and resilient in the face of looming deadlines and changes in schedule. The team had occasion to use his skills to literally "blind the client with science" a couple of times, which I found particularly enjoyable to watch. I appreciated not only Brian's technical skills but also his wry sense of humor and the fact that he willingly undertook every task no matter how small/large trivial or complex. I would dearly welcome the opportunity to work with Brian again.", "I was part of the team that hired Brian at Entelos Inc and I trained and worked with him on a client research project over a period of 4 months upon his joining the company. I was impressed by the speed at which Brian learned a very complex computational disease model, and his ability to assume the engineering/technical leadership on a client research project so soon after completing his PhD and joining the company. He is extremely dedicated, investing whatever effort is needed to achieve project goals, and is both bright and innovative in his approaches to problem-solving. He takes the initiative to learn new areas related to his work (e.g., independently studying immunology and rheumatology texts and literature for the project we worked on together). In addition to his excellent performance, I would also say Brian is one of the most pleasant, courteous and universally liked individuals I have had the pleasure to interact with.", and "Brians worked in my lab for only a few months, but he performed exceptionally well and he was very productive for the time he was there. Brian is a meticulous and highly inquisitive scientist."
Listed skills include Systems Biology, Biotechnology, Assay Development, Biomedical Engineering, and 14 others.
Current workplace
Brian Schmidt's current company
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14 roles · 28 years
Brian Schmidt work experience
A career timeline built from the work history available for this profile.
Executive Director, Head Quantitative Systems Pharmacology & Physiologically Based Pharmacokinetics
• Lead and manage a team of about 30 scientists to broadly inform and impact activities from research through clinical development across the portfolio applying mechanistic modeling strategies.• Clinical Pharmacology, Pharmacometrics, and Bioanalysis department Senior Leadership Team member
May 2022 - Nov 2024
Senior Director, Head Quantitative Systems Pharmacology & Physiologically Based Pharmacokinetics
Jan 2021 - May 2022
Director / Research Fellow (Quantitative Systems Pharmacology)
• Quantitative Clinical Pharmacology group member within Clinical Pharmacology and Pharmacometrics• Lead for QSP efforts and a small group in the oncology/immuno-oncology therapeutic area
Jul 2019 - Jan 2021
Associate Director / Senior Principal Scientist (Quantitative Systems Pharmacology)
• Quantitative Clinical Pharmacology group member within Clinical Pharmacology and Pharmacometrics• Lead for QSP efforts and a small group in the oncology/immuno-oncology therapeutic area
Mar 2016 - Jul 2019
Senior Research Investigator (Quantitative Systems Pharmacology)
• Quantitative Clinical Pharmacology group member within Clinical Pharmacology and Pharmacometrics• Apply Quantitative Systems Pharmacology models and approaches to advance small molecules and biologics from preclinical research through clinical trials with a focus on oncology and immuno-oncology therapeutic areas• Manage platform development projects• Develop QSP tools, workflows, and algorithms
Mar 2014 - Mar 2016
Postdoctoral Associate (Computational Biology)
• Dr. Sumit K. Chanda's Lab, Infectious and Inflammatory Disease Center• Lead the integration of multi-omics data sources (RNA-seq, RNAi screens, APMS) using network-based approaches to interpret results and propose follow-up experiments for high-confidence targets to elucidate drug targets and host factors that restrict viral replication and impact disease outcomes
2013 - 2014
~1 yr
Postdoctoral Scholar (Systems Biology)
• Dr. Bernhard Ø. Palsson's Systems Biology Research Group, Bioengineering Department• Developed algorithms and employed genome-scale mathematical models of cellular metabolism constructed from annotated genomes to guide the functional, integrated interpretation of microarray (oligonucleotide), proteomic (LC-MS/MS), and metabolomic (GC-MS) samples to develop insights into the adaptive responses of bacterial pathogens in host-mimicking environments• Communicated with pathogen experts and omics cores across sites to refine analyses, develop recommendations for follow-up experiments, and contribute to manuscript preparation for publication in peer-reviewed journals• Wrote research plans for grant and fellowship applications
2011 - 2013
~2 yrs
Dynamics Engineer (Quantitative Systems Pharmacology)
Entelos
• Performed research with mechanistic computational models of human disease pathophysiology in multiple therapeutic areas, including rheumatoid arthritis, cardiovascular disease, and type 2 diabetes• Developed mathematical representations for novel therapeutics and new biology, developed predictions of clinical efficacy, optimized PK/PD parameters, and performed sensitivity analysis to identify the pathways most important for efficacy• Performed statistical population-level research with virtual patient cohorts to optimize clinical trial design and identify multianalyte biomarkers of clinical efficacy • Lead meetings to present research results and make recommendations to scientists in pharmaceutical research and development groups• Scoped new research projects, developed project timelines, and lead research projects
2009 - 2011
~2 yrs
Postdoctoral Research Associate (Systems Biology)
• Dr. Jason Papin's Computational Systems Biology Lab, Department of Biomedical Engineering• Employed partial least squares regression and support vector machine learning classification on reverse phase phosphoprotein array data from cancer cell lines to develop predictors of metastasis, growth, and response to chemotherapeutics• Utilized expression microarray data to adapt a linear genome-scale model (H. sapiens Recon 1) to represent a murine cardiomyocyte-specific model of metabolic function in health and diabetes
2009 - 2009
Graduate Research Assistant
• Dr. Michael B. Lawrence's Lab, Department of Biomedical Engineering• Developed computational models, tracking algorithms, molecular biology methods, and new assays to elucidate molecular characteristics that govern leukocyte adhesion biophysics under vascular shear flow
2003 - 2009
~6 yrs
Research Extern
• Designed and tested a novel acoustic flow system and characterized the acoustic and adhesive properties of monodisperse, polymer-shelled microbubbles being developed for ultrasound contrast and drug delivery
Jun 2006 - Aug 2006
Quality Engineer
Whatman Hemasure
• Quality Engineer at an ISO 9001:1994 certified and 21CFR820 regulated manufacturer of leukoreduction systems
2002 - 2002
Engineering Co-Op
• Worked on four, three-month internships in process, project, and production engineering groups in both the chemical and biopharmaceutical industries
1999 - 2001
~2 yrs
2 education records
Brian Schmidt education
Phd, Biomedical Engineering
University Of Virginia
Bs, Chemical Engineering
University Of Pittsburgh
FAQ
Frequently asked questions about Brian Schmidt
Quick answers generated from the profile data available on this page.
What company does Brian Schmidt work for?
Brian Schmidt works for Madrigal Pharmaceuticals.
What is Brian Schmidt's role at Madrigal Pharmaceuticals?
Brian Schmidt is listed as Executive Director, Clinical Pharmacology at Madrigal Pharmaceuticals.
What is Brian Schmidt's email address?
AeroLeads has found 1 work email signal at @bms.com for Brian Schmidt at Madrigal Pharmaceuticals.
Where is Brian Schmidt based?
Brian Schmidt is based in Princeton, New Jersey, United States while working with Madrigal Pharmaceuticals.
What companies has Brian Schmidt worked for?
Brian Schmidt has worked for Madrigal Pharmaceuticals, Bristol Myers Squibb, Sanford-Burnham Medical Research Institute, Uc San Diego, and Entelos.
How can I contact Brian Schmidt?
You can use AeroLeads to view verified contact signals for Brian Schmidt at Madrigal Pharmaceuticals, including work email, phone, and LinkedIn data when available.
What schools did Brian Schmidt attend?
Brian Schmidt holds Phd, Biomedical Engineering from University Of Virginia.
What skills is Brian Schmidt known for?
Brian Schmidt is listed with skills including Systems Biology, Biotechnology, Assay Development, Biomedical Engineering, Cell Culture, Matlab, R, and Immunology.
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