Scott Mack Email and Phone Number

Coordinate with marketing and sales to support a highly productive, market forward, technical evaluation service with more than 20 participants across the globeAnalyze, interpret, communicate, and assist customers utilize icIEF-UV/MS data to improve outcomes at every step of the biotherapeutic development life cycleDevelop analytical solutions for challenging pre and post submission compoundsPublish and or present groundbreaking results from biopharmaceutical collaborations to drive interest in the new field of deep intact protein characterization and identification Support advanced research within SCIEX and across Danaher’s life science organizations

Assay Development, Application, and System Integration Lead for the team first to perform and publish the results of rapid comprehensive analysis of mAb charge isoforms by icIEF-UV/MS.Expand Intabio's intellectual property position, being listed on five awarded patents and a further seven patent applications for inventions conceived to allow for robust MCE-MS analysis by microfluidic device Generated compelling data used to secure a 2.3 million NIH Fast Track SBIR grant, 9.5 million Series A and 18 million dollar Series B funding roundsActing group’s technical expert on the subject matter of imaged and chemically mobilized isoelectric focusing separation systems along with electrospray ionization and mass spectrometry instrumentationOversee the development, verification, and validation of a comprehensive suite of novel reagent products and assay methodologies

Member and Applications Lead of an advanced research and feasibility team that designed, developed, and integrated a “First in Class” capillary electrophoresis instrument (Maurice), capable of simultaneous UV Absorbance and Native Fluorescence Imaged Isoelectric Focusing DetectionLed an Isoelectric Focusing chemistry development team that resulted in the simultaneous release of 11 new reagents, an inclusive method development guide, and all marketing/sales technical content in support of the Maurice Instrument commercial launchQuality by Design (QbD) and Design for Six Sigma (DFSS) champion, guiding the implementation of comprehensive product development strategies, including both systematic process characterization techniques and the proper use of statistical tools to facilitate data driven decision making Subject Matter Expert, supporting iCE product line manufacturing, marketing, sales, and customer support activities

Spearhead studies into novel analytical strategies with iCE, MFI and Simple Western instrumentation targeted for Biopharma applications Technical lead for applications and chemistry development of iCE 3 a product line that had three successful product releases and a reagent manufacturing site transfer in 2014Adapt, demonstrate, and champion the use of Quality by Design techniques to improve both assay consistency and reagents manufacturability Advance technical communications into a global customer base presenting seven technical seminars, authoring three technical bulletins, and an article in Genetic Engineering News Establish test procedures, perform systems integration, and evaluate performance on prototype capillary and detection systems

Provided advanced applications expertise for iCE, MFI, and Simple Western product lines while coordinating customer support for the Biologics Western Region in North America containing over 150 installed systemsParticipated in presales activities by presenting technical seminars and/or performing instrument demonstrations including a highly successful iCE 280 to iCE 3 comparability study that resulted in the sale of 40 plus units at a single siteDevelop novel analytical methodologies for biotherapeuticsAttend product development core team meetings as a contributing memberPresent results on new application development or analytical best practices through webinars and conference seminars

Developed novel methods and chemistry for GeXP, CEQ, PA 800, and SNPStream product lines. Lead researcher on an improved cIEF chemistry and separation methodology that was eventually adopted by Genentech Commercial Quality Control to provide as an identification assay for both Trastuzumab and Rixtuximab, compunds that generated over 15.7 billion dollars of revenue in 2013Participated in every stage of the product development life cycle from feasibility to post product release support including the creation of an improved sheathless ESI emitter tip and liquid phase microfabrication techniqueSupported CE and CE-MS commercial operations by authoring eight posters, four technical bulletins, and seminal paper on cIEF referenced in 79 articles following publication in 2009Managed a highly productive network of academic and industrial collaborators that resulted in successful application of a microvial ESI needle to perform highly resolved cIEF-MS analysis of intact proteins, the results of which were published in 2011

Develop methods for automated tissue processing and genomic DNA isolationPolymorphism genotyping by TaqMan and SNP Plex assaysMicrosatellite Analysis by PCR fragment analysisDNA Polymorphism discovery by Sanger SequencingSchedule projects and troubleshoot assaysMaintain laboratory equipment and manage inventory stocksTrain graduate students and new lab personnel

Validated FDA and Non-FDA approved in vitro assays for clinical medical diagnostic useWrote SOP’s outlining the capabilities and proper implementation of validated assaysTrained Clinical Laboratory ScientistsMaintained a laboratory notebook

Designed and performed experiments to support the development of a AAV Rep 68 incorporated mammalian display technologyIndependently researched and developed BL-21 expressed biotinylated proteins for an Assay Design and Implementation GroupMaintained a lab notebook and presented data to scientists and project review boards