Scott Milos Email & Phone Number

New Jersey, United States

Pennsylvania, United States

• Overview: Performed target identification, validation, and characterization of two oncology synthetic lethality programs using a small molecule inhibitor approach.
• Evaluated the activity, efficacy, and molecular consequences of orthosteric and allosteric small molecule inhibitors using a variety of phenotypic in vitro assays to support mechanism of action studies (JESS, flow.
• Designed dose-dependent and temporal PD biomarker characterization experiments and optimized associated biochemical assays to improve signal to background and drug response.
• Prepared, analyzed, interpreted, and communicated data to be shared at departmental meetings and other cross functional group meetings.
• Maintained documentation of experiments using the internal ELN system.

Toronto, Ontario, Canada

• Overview: Managed the functional assay development of a CNS therapeutic target, assessing protein functional changes in response to expression modulation following Anti-Sense Oligo (ASO) treatment in vitro
• Spearheaded the research and development of functional assays (alphaLISA, ELISA, IP) related to in vitro molecular target detection and function to validate disease related cellular phenotypes, conducting experiments.
• Established timelines, acceptance criteria, and go/no-go criteria related to developed assays to aid in decision making of whether to pursue a molecular target in the company’s preclinical portfolio.
• Generated and organized a functional assay data package related to a therapeutic target for presentation to senior management.
• Worked closely with high-throughput screening core to assay 2500+ ASOs on iPSC derived neurons or primary human hepatocytes at RNA and protein level to screen for drug candidate and follow up hits by assaying using.
• Ensured complete documentation using Electronic Lab Notebook while executing various R&D experiments.

Toronto, Ontario, Canada

• Overview: Managed the pre-clinical research and development of two molecular precision medical tools used to aid in treatment strategies of pediatric brain tumors.
• Developed cell culture models involving activation or repression of 4 oncogenic cell signaling pathways to assess and validate signal detection in precision medicine tool.
• Extracted biomolecules from over 500 precious formalin-fixed paraffin embedded human tissue samples and compiling detailed data to comprise project databases and cohorts for molecular analysis.
• Reviewed and analyzed data obtained from over 1000 samples, performed quality control, and reported progress, technological deficiencies, and other relevant findings at weekly meetings and stakeholder meetings.
• Wrote SOPs and related documents concerning the operation/instillation/performance qualifications of the two precision medicine tools, working with Quality Systems team for clinical implementation.
• Managed and mentored a summer co-op student and trained other lab members on various molecular technologies.

Toronto, Ontario, Canada

(The same a described for Lab Research Project Coordinator)

Toronto, Ontario, Canada

• Overview: Researched how oncogenic histones mutations alter the normal protein-protein interactome and investigated the role of NF1 alternative splicing in glioma.
• Cloned and amplified plasmids used to generate over a dozen of stably expressing cell lines in a plethora of cell backgrounds via transfection or lenti-viral transduction.
• Aseptically cultured dozens of cell-lines, maintaining nitrogen stocks, and harvesting cells for the isolation of molecular material for analysis (DNA/RNA/protein) with high efficiency.
• Performed various molecular cell biology techniques to contribute data towards 2 major projects, resulting in 4 manuscripts, two of which are currently published in high impact journals.

London, Ontario, Canada

• Overview: Teaching assistant for Pharmacology Lab (Pharm 3580Y):
• Taught undergraduate students the importance of GLP, meticulous experimental design, analytical methods, data interpretation, statistical analysis, and techniques for scientific communication.
• Conducted tutorials on the subject of pharmacology, encouraging curiosity and learning.
• Answered student questions, provided constructive feedback, meticulously graded written reports and oral/poster presentations in a timely manner.

Toronto, Ontario, Canada

• Overview: QA summer student testing software function of NexJ Systems healthcare platform.
• Rigorously tested the intended functionality of core patient-practitioner health CRM software platforms in accordance with internal design documents meeting project milestones.
• Identified over 500 deficiencies (bugs) related to software function and worked with developers to resolve roadblocks and improve overall functionality and user experience.
• Wrote novel test plans and functional design documents to increase scope of software functionalityand reflect altered client objectives.
• Successfully led the Health Platform Development Team as scrum master for several software development sprints.
• Conducted live demos to highlight new software functionality to other departments and senior personnel.

Toronto, Ontario, Canada

QA summer student testing software function of NexJ Systems healthcare platform

Toronto, Ontario, Canada

QA summer student testing core software functionality

Toronto, Ontario, Canada

QA summer student of core software functionality

Master Of Science - Ms, Physiology And Pharmacology

Bachelor Of Science - Bs, Hon. Spec. Pharmacology