Architect of large-scale and small-scale bioinformatics analysis and knowledge management systems. Software engineering team builder and organizational strategist.
Scott Smith Technical Consulting, Llc
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OwnerScott Smith Technical Consulting, Llc Jul 2015 - PresentSan Francisco Bay AreaI help launch build out initial tech infrastructure, software, databases, for biotech companies funded by top investors. I also come in to work with existing teams to extend existing systems. For some companies I'm the entire engineering team. In others I do specialty work that the execs want that is independent of regular staff.
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Head Of EngineeringKarius, Inc. Nov 2014 - Jul 2015San Francisco Bay AreaHeaded engineering for a stealth startup. Diagnostic for infectious disease: "hypothesis-free" pathogen detection.
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Engineering / Product DevelopmentCounsyl Oct 2013 - Nov 2014
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"Council Member" (Consultant)Glg Research Mar 2013 - Jun 2014Austin, Texas AreaConsulting on bioinformatics and IT infrastructure.
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Director Of Informatics, Special ProjectsThe Genome Institute At Washington University School Of Medicine Nov 2012 - Oct 2013Greater St. Louis AreaI focused on helping take the analysis software systems at the Institute and bend them to the needs of cancer clinicians, with the goal of closing the loop between classical research and clinical decision support. -
Manager Of Application Programming And Development, Analysis PipelineThe Genome Institute At Washington University School Of Medicine Feb 2008 - Nov 2012I led a team that grew from 5 to 20 software engineers with the goal of turning the work of computational biologists into a rapidly-iterating analysis engine. We created The Genome Modeling System, with APIs for data tracking, automated documentation, search, and verifiable reproducibility. We sequenced the first complete cancer genome and published it in Nature in November 2008, then scaled that system to sequence dozens, then hundreds, then thousands of genomes per year. I hired developers for my own group, and also seeded other teams with talent from running an agressive talent recruitment and evaluation campaign. I initiated a program to begin public release of software under open-source licenses (LGPL). By the end of 2012 the ecosystem created had led both programmers and computational biologists to contribute over 1500 shareable components to our analysis system, eclipsing the largest single public project of its kind in quantity by nearly 50%, with approximately the same volume of code. -
Manager, Informatics Systems IntegrationThe Genome Center At Washington University School Of Medicine Jun 2007 - Feb 2008Greater St. Louis AreaI led an initial experimental small team to attempt to integrate federated groups of analysts into the larger IT infrastructure of the organization, that previously just serviced laboratory tracking. This experiment led to the creation of the subsequent Analysis Pipeline Group, which put analysis engineers under more formal leadership. -
Assistant Manager And Architect, Automated Pipeline Group (Lims)The Genome Sequencing Center At Washington University School Of Medicine Jun 2003 - Jun 2007Greater St. Louis AreaAs the group I worked in absorbed the other development groups around it, I took an assistant manager position, and led the database and software architecture aspects of a developing large-scale Laboratory Information Management System (LIMS). During this time, replacing manual activity with automation led us to be the most cost effective large-scale sequencing center in the U.S., and the second highest funded. I partnered with the head of Systems to convert our operation entirely over to Linux. I introduced automated testing. I oversaw the creation of a data warehousing and OLAP system for reporting. I also oversaw the integration of the first "next-generation" sequencing technologies, starting with the 454, and ending with Illumina (then Solexa) NGS. -
Senior Software DeveloperThe Genome Sequencing Center At Washington University School Of Medicine Feb 2001 - Jun 2003Greater St. Louis AreaI began work at The Genome Sequencing Center near the peak of the Human Genome Project. They had brought on-line large databases to deal with a data scale up and were hiring professional software engineers to re-architect the organically grown academic systems into something to cope with the scale.I initially brought on-line data management for DNA library preparation to feed into newly developed touchscreen systems. I authored the software application used by management to organize the projects to handle each piece of our assigned human chromosomes. I wrote a software APIs which became the exclusive way for the software system to access their large Oracle database for the following six years. -
ConsultantOmic Medicine Oct 2012 - Jun 2013St. Louis, MoDevelopment and planning for application of genomic and bioinformatic methods to a clinical sequencing environment. Customized software to bring on-line NGS analysis pipelines.
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Independent Contractor / Software DeveloperCornerstone Solutions Group Nov 1997 - Nov 2000Greater St. Louis AreaAs a contract software developer I was one of a team of 20 developing IT infrastructure replacement for an office product distribution company. I implemented parts of their purchasing interface, parts of their product data management interface, as well as the entirety of their just-in-time inventory algorithm back-end, and the interface used by purchasing agents to review it. I also built the integration layer with their warehousing solution, and a testing framework used to examine and validate cross-database integration tests.
Frequently Asked Questions about Scott M. Smith
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Scott M. Smith works for Scott Smith Technical Consulting, Llc
What is Scott M. Smith's role at the current company?
Scott M. Smith's current role is I help launch and/or scale software and data infrastructure for biotech companies. Architecture layout for new companies. Rescue struggling systems. Align teams around generating results, shipping..
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Scott M Smith
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