MOLECULAR CONTROL OF CELL DEATH AND INFLAMMATIONMy laboratory is interested in how different modes of cell death (apoptosis and necrosis) influence activation of the immune system by promoting or suppressing inflammation. We also work on how IL-1 family cytokines (IL-1, IL-18, IL-33, IL-36, IL-37) are processed and activated to initiate inflammation.Selected papersClancy DM,..... Martin SJ. (2018) Extracellular Neutrophil Proteases Are Efficient Regulators of IL-1, IL-33, and IL-36 Cytokine Activity but Poor Effectors of Microbial Killing. Cell Reports 22, 2937-.Henry CM & Martin SJ. (2017) Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory "FADDosome" Complex upon TRAIL Stimulation. Molecular Cell 65, 715-.Kearney CJ & Martin SJ. (2017) An Inflammatory Perspective on Necroptosis. Molecular Cell 65, 965-.Henry CM,.... Martin SJ. (2016) Neutrophil-Derived Proteases Escalate Inflammation through Activation of IL-36 Family Cytokines. Cell Reports 14, 708-722.Hollville E,... Martin SJ. (2014) Bcl-2 Family Proteins Participate in Mitochondrial Quality Control by Regulating Parkin/PINK1-Dependent Mitophagy. Molecular Cell 55, 451-. Cullen SP,.... Martin SJ. (2013) Fas/CD95-Induced Chemokines Can Serve as "Find-Me" Signals for Apoptotic Cells. Molecular Cell 49,1034-48Carroll RG & Martin SJ. (2013) Autophagy in multiple myeloma: what makes you stronger can also kill you. Cancer Cell 23, 425-6Afonina IS,..... Martin SJ. (2011) Granzyme B Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α. Molecular Cell. 44, 265-.Elgendy M,.....Martin SJ. (2011) Oncogenic ras-induced expression of noxa and beclin-1 promotes autophagic cell death. Molecular Cell 42, 23-.Lüthi AU..... Lavelle EC, Martin SJ. (2009) Suppression of interleukin-33 bioactivity through proteolysis by apoptotic caspases. Immunity. 31, 84-98.Specialties: Molecular biology, Genetics, Cell biology, Immunology, Cancer.