Sean Quinn, Ph.D

Sean Quinn, Ph.D Email and Phone Number

Research Scientist @ Scout Bio | Therapeutic Antibody Purification and Characterization @ Scout Bio
philadelphia, pennsylvania, united states
Sean Quinn, Ph.D's Location
Morrisville, Pennsylvania, United States, United States
About Sean Quinn, Ph.D

With over 8 years of experience in protein biochemistry (4 years graduate plus 4 years post-doctoral), I am passionate about advancing the understanding and treatment of rare diseases. My mission is to leverage my expertise in antibody purification and biochemical characterization to discover and screen novel protein therapeutics that can improve the quality of life of patients. As a postdoctoral scientist at Children's Hospital of Philadelphia (CHOP), I was part of a collaborative and innovative team that is dedicated to finding solutions for complex and challenging medical problems in Hematology.In my post-doctoral research role, I successfully identified and screened monoclonal antibodies targeting factor V, a key protein involved in blood coagulation. Two of these antibodies have shown promising results in enhancing thrombin generation in human hemophilia A plasma. In an internal collaboration to evaluate in vivo efficacy, these antibodies exhibited procoagulant activity in a hemophilia A mouse model. This work has been supported by the National Bleeding Disorder Foundation and was presented at prestigious conferences such as the American Society of Hematology and International Society on Thrombosis and Hemostasis. I have also used various skills and techniques, such as mammalian cell culture, protein purification, Octet/BLI, Western Blotting, ELISA, enzymatic assays, and thrombin generation assays to optimize and validate the lead antibody candidates.

Sean Quinn, Ph.D's Current Company Details
Scout Bio

Scout Bio

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Research Scientist @ Scout Bio | Therapeutic Antibody Purification and Characterization
philadelphia, pennsylvania, united states
Website:
scoutbio.co
Employees:
8
Sean Quinn, Ph.D Work Experience Details
  • Scout Bio
    Research Scientist
    Scout Bio Aug 2024 - Present
    Philadelphia, Pennsylvania, United States
  • Children'S Hospital Of Philadelphia
    Postdoctoral Scientist
    Children'S Hospital Of Philadelphia Jul 2019 - Aug 2024
    Greater Philadelphia Area
    Postdoctoral research fellowship focused on developing/screening monoclonal antibodies targeting factor V. Through my work at the Children's Hospital of Philadelphia, two lead-candidate monoclonal antibodies have been identified that reverse the effect of Activated Protein C on thrombin generation and have been shown to be procoagulant in an in vivo hemophilia A mouse model. This work was supported by the National Bleeding Disorder Foundation.
  • Rensselaer Polytechnic Institute
    Phd Candidate
    Rensselaer Polytechnic Institute Aug 2014 - May 2019
    Troy, Ny
    Kinesins are remarkable microtubule-based molecular motors in that they couple nucleotide hydrolysis to movement at millisecond or faster time scales! Single-molecule microscopy and stopped-flow kinetics experiments can provide the rates of different transitions within a kinesin’s stepping-cycle but cannot always provide a complete picture of how each motor domain behaves throughout a processive run. My research aimed to determine how heterodimerization of kinesins, particularly kinesin-2, impacts the mechanochemical properties of its two motor domains. Addressing this question using modeling allowed us to infer why heterodimeric kinesins evolved and their significance in the cell. This research involved using computational modeling with MATLAB, single-molecule, and stopped-flow kinetics approaches.
  • Rensselaer Polytechnic Institute
    Graduate Teaching Assistant
    Rensselaer Polytechnic Institute Aug 2014 - May 2015
    Troy, Ny
    Served as a teaching assistant for both the Introductory Biology laboratory course and Introductory Cell Biology course.
  • Eisai
    Drug Metabolism And Pharmacokinetics Intern
    Eisai May 2013 - Aug 2013
    Andover, Ma
    Identified the kinetics of the formation of a novel metabolite using HPLC-MS. The work culminated in a presentation of the work to senior staff.

Sean Quinn, Ph.D Education Details

Frequently Asked Questions about Sean Quinn, Ph.D

What company does Sean Quinn, Ph.D work for?

Sean Quinn, Ph.D works for Scout Bio

What is Sean Quinn, Ph.D's role at the current company?

Sean Quinn, Ph.D's current role is Research Scientist @ Scout Bio | Therapeutic Antibody Purification and Characterization.

What schools did Sean Quinn, Ph.D attend?

Sean Quinn, Ph.D attended Rensselaer Polytechnic Institute, Rensselaer Polytechnic Institute, Rensselaer Polytechnic Institute.

Who are Sean Quinn, Ph.D's colleagues?

Sean Quinn, Ph.D's colleagues are Lanice Evans, Katherine Balak Humphrey, Fran Gaconnier, Elizabeth Nolen, Kara Claxton, Caitlyn Hayes.

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