Biogate labradorites is a major provider of IVD products in Canada.ResponsibilitiesDeveloped purification process on antibodies and recombined proteins from ascites and cultural cells.Achievement Optimized purification process to obtain high bio activities antibodies and proteins;Designed High-throughput purification platform to perform 10~20 proteins purification at same time;Scale-up purification of proteins to obtains maximum 100g for one elutionProteins analysis, SOP and report writing under GLP regulation.

GE Healthcare Life Sciences is the Lead of chromatography products and technology in Bio-Pharmaceutical Downstream.Responsibilities:Application development for the clients by using GE process products(Purification resins, AKTA Developed new purification methods for the Vaccine and mAb customers by using GE resins ; monitor the purification process by HPLC and other analytic methods.Guided Scale-up customers to smooth next step of clinical stage of new drugs or Biosimilar, following the cGMP regulations and GE workflow.Trained the customers in GE Shanghai Lab strictly following the SOP.Achievements: Developed 15 new applications for the new start projects by using GE purification resins;Helped 4 customers start their scale-up projects, successfully using GE process level equipment and resins. Joined Compliance training program regularly in GE Compliance Reporting System.

Bio-Rad Chromatography Division is focus on the chromatography resins and systems with unique technique.Responsibilities: Application development of Bio-Rad process chromatography resin, like CHT, MacroPrep, Affi-gel Blue and Bio-rad Chromatography System and Column. Achievements: Developed application in Fc-fusion Project using Bio-Rad Resins for aggregation removal;Developed applications for the new vaccine projects by using Bio-Rad CHT, including Pneumococcal vaccine, Pneumococcal vaccine, Pertussis vaccine and HPV vaccine.Developed applications for the new insulin projects by using Bio-rad IEX resin MacroPrep;Named “Annual Star”employee of the year 2010, Bio-Rad Asia-Pacific.

CRO company, providing drug development services for Pharmaceutical companies like Pfizer, Merck and J&J;Responsibilities Proteins expression, Purification and Analysis; The proteins mainly cell factors; IgG, Fab, Fc-Fusion proteins, and other targets for drug development. Leader of 4 people team for proteins expression and purification;Wrote reports for the projects from different customers;Quality Control test design and perform;Achievements: Project leader of cytC project, Proteins expression; Cell culture, Purification and Quality Control;Porojet ladder of Antibodies production, Purification and Quality Control;Designed the high-throughout purification system and endotoxin control methods of Fc-fusion proteins;

Biotech Pharmaceutical is a Sino-Cuba Bio-pharmaceutical company, The key product is therapeutic mAb.Responsibilities HPLC method development and validation. SOP Writing for the test methods for the GMP regulation requirement.Biochemistry and Molecular Biology tests of mAb products or cell lines. Included purification by SEC-HPLC, SDS-PAGE; Peptide Mapping, and so on;Validation of test methodsCalibration and maintenance of QC equipmentAchievements: QC lab establishment , purchasing the equipment, test methods design and Wring 20+ SOPs;Trained to get the certificate of hazardous chemicals management year 2007;Awarded the certificate of cGMP Training Course from Biotech Pharmaceutical 2006;