Serena Moretti Email & Phone Number

Mechelen

Translating R&D designs into manufacturing products according to technical requirements, quality levels, project plan and budget. Main activities include:- Feasibility testing of new IVD products, designing experiments, follow-up with lab technicians interpretting results, approving reports, identifying risks.- Assess incoming materials: quality, stabilty, chemical and manufacturing compatibility, chemical and biological safety- Develop stability strategy in compliance with national… Show more Translating R&D designs into manufacturing products according to technical requirements, quality levels, project plan and budget. Main activities include:- Feasibility testing of new IVD products, designing experiments, follow-up with lab technicians interpretting results, approving reports, identifying risks.- Assess incoming materials: quality, stabilty, chemical and manufacturing compatibility, chemical and biological safety- Develop stability strategy in compliance with national and international (CE, FDA, PMDA) regulatory requirements and other applicable guidelines.- Proposes, develops and validates QC methods, including transfer to operations- Assess risks for product materials, product design and manufacturing processes - Event management in case of NCR, Issues and CAPA during product life-cycle- Conforming to legislation & regulations ISO13485, IVD R directive, ISO14971, 820 CFR, GxP (e.g: GLP, GMP, GDP)- Process owner: responsible during audits and training of personnel Show less

Bioscience Engineering Department

FWO PhD fellowship grant to study "The importance of airborne bacterial endotoxins in an urban environment"- Implementing and validating a new sampling approach for the collection of airborne endotoxins (LPS) in an urban environment- Comparing different methods for the quantification of endotoxin, including the LAL assay, the recombinant Factor C (rFC) assay and human recognition (in vitro) of endotoxin via the HEK hTLR4 reporter cell line. - Determining relative pro-inflammatory… Show more FWO PhD fellowship grant to study "The importance of airborne bacterial endotoxins in an urban environment"- Implementing and validating a new sampling approach for the collection of airborne endotoxins (LPS) in an urban environment- Comparing different methods for the quantification of endotoxin, including the LAL assay, the recombinant Factor C (rFC) assay and human recognition (in vitro) of endotoxin via the HEK hTLR4 reporter cell line. - Determining relative pro-inflammatory response (TNFα, IL-1β, IL-8, etc) of complex environmental samples in human cell lines and establishing mechanistic pathways and cell viability. -RNA extraction, cDNA synthesis, primer design and validation, quantitative real time PCR, adhering to the MIQE guidelines -protein expression through ELISA- Investigate oxidative stress gene markers (qPCR) and detection of superoxide radicals in cell models through EPR (electron paramagnetic resonance)- Analysing transition metal concentrations (ICP-MS), particle count and distribution (Coulter counter and flow cytometry), total organic carbon, PAHs (polycyclic aromatic hydrocarbons)- Scanning electron microscopy (SEM)-Analysing complex data sets Show less

Belgium

I worked under Prof. Sarah Lebeer to set up the new laboratory of Applied Microbiology and Biotechnology within the Bioscience Engineering Department. Here, I was involved from the beginning: from negotiating the architectural layout of the microbiology, molecular and cell culture laboratories, to choosing which reagents/equipment to purchase, setting up methodological, safety, data/sample storage protocols, validating protocols, establishing collaborations, applying for funding, and teaching… Show more I worked under Prof. Sarah Lebeer to set up the new laboratory of Applied Microbiology and Biotechnology within the Bioscience Engineering Department. Here, I was involved from the beginning: from negotiating the architectural layout of the microbiology, molecular and cell culture laboratories, to choosing which reagents/equipment to purchase, setting up methodological, safety, data/sample storage protocols, validating protocols, establishing collaborations, applying for funding, and teaching students. Show less

Belgium

Training in GMP, microbiology method validation (bioburden, sterility, pyrogen testing, etc) Discovery of novel & rapid microbiology biosystems

University Of The Free State, Virology Department

- Assisting in an ongoing HIV genotyping research project at UFS medical faculty for the administration of new ARVs- Genotyping of Human herpesvirus 8 (Kaposi's Sarcoma) for correlation studies of tissue lesions- Ongoing project on determining the prevalence of Hepatitis E in South Africa- Sequencing of a measles virus causing subacute sclerosing panencephalitis (SSPE) with atypical symptoms- Evaluation of the use of plasma preparation tubes for HIV viral load testing on the… Show more - Assisting in an ongoing HIV genotyping research project at UFS medical faculty for the administration of new ARVs- Genotyping of Human herpesvirus 8 (Kaposi's Sarcoma) for correlation studies of tissue lesions- Ongoing project on determining the prevalence of Hepatitis E in South Africa- Sequencing of a measles virus causing subacute sclerosing panencephalitis (SSPE) with atypical symptoms- Evaluation of the use of plasma preparation tubes for HIV viral load testing on the COBAS AmpliPrep/COBAS TaqMan HIV-1 version 2.0 (Awaiting Publication)- Techniques mainly include: DNA/RNA extractions, PCR, bacterial cloning and sequencing Show less

University Of The Free State

Immunology Theory and Practical (third year level)

Doctor Of Philosophy - Phd, Bioscience Engineering

Interplay of bacterial endotoxins and transition metals in the inflammatory capacity of airborne particulate matter

Magister Scientiae, Microbiology, Cum Laude

Dissertation title, "The molecular study of Mycoplasma gallisepticum field isolates from poultry in southern Africa"

Baccalaureus Scientiae Honores: Biochemistry, Majored In Biochemistry And Microbiology

- Subjects included: General Analytical and Chromatographic Techniques in Biochemistry; Enzymology, Advanced Protein Structure.

Baccalaureus Scientiae: Microbiology, Majored In Microbiology And Biochemistry

Matriculation, English; Afrikaans; Physiology; Mathematics; Accounting; Science; Biology; Commercial Maths

Activities and Societies: -Debating -First team Hockey Free State top 20 Matric Achiever of 2006

Doctor Of Philosophy (Phd), Bioscience Engineering

Microbial analysis of airborne particulate matter of polluted air