Seul-A Bae Email & Phone Number

West Hills, Ca

Fornebu

Developed a commercial production process for Lysoveta, a derivative of Antarctic krill oil. Used design of experiment method to select production parameters. Used quantitative modeling of kineticequations to characterize the production process and develop control strategy. Performed scale-up of production process and tech transfer to internal manufacturing and supply department. Provided technical consultation for marketing, sales, and customers. Developed production cost models of Lysoveta and existing krill oil products to streamline the research portfolio.

West Point, Pa

• Proficiency in NONMEM as the modeling and R as the simulation and visualization tool.• in vitro (hollow fiber)-in vivo (mice) traslation of semi-mechanistic tPKPD model for antibacterial combination therapeutics.• Utilized the tPKPD model to predict bacterial growth in mice with humanized doses.• The results support the conclusion from the hollow fiber studies that AUC normalized by the minimum inhibitory concentration (MIC) is the best PKPD index for predicting efficacy.

Piscataway, Nj

• Expertise in Systems Biology and Quantitative Systems Pharmacology• Mathematically modeling the effect of circadian disruption on glucose metabolism• Investigating the synergistic role of two environmental zeitgebers, light/dark cycle and feeding/fasting cycle and hepatic metabolism• Investigating the effect of circadian rhythmicity on insulin secretion• Awards:o National Science Foundation Graduate Research Fellowship (2015-2018)o Rutgers Biotechnology Training Program Fellowship supported by NIH (2014-2015)

Framingham

• Developed second generation upstream process (continuous suspension mammalian cell culture) for an approved biologics drug• Experienced in mammalian cell culture (both suspension and microcarrier) of multiple scales, including high-throughput plates, bench top bioreactors, and pilot-plant• Experienced in disposable technology (reactors and sensors)• Applied DOE based experiments for media/clone selection and parameter optimization • Curated and analyzed data obtained from multiple departments using JMP and Matlab• Led technology evaluation for real-time measurement of cell density (using RAMAN spectroscopy) and OUR (using gas analyzer)• Served as a safety officer for the department

Woburn, Ma

• Developed and scaled up cellulosic bio-fuel production• Developed novel saccharification and fermentation process and transferred technology to pilot-plant• Designed and purchased and operated pilot-plant scale equipment• Created and managed MSDS and SOPs for the laboratory• Responsible for waste management for the company• Presented to senior management and investors

• Optimized IgG1 production of CHO cell culture in a disposable stir-tank bioreactor. • Optimized culture conditions for MethA cells with DASGIP bioreactors and evaluated automated reactor sampling system.

• Evaluated filtration process in disposable rock-bed bioreactors (WAVE)

• Developed an in vitro screening system for prolonged duration local anesthesia for patients suffering from chronic pain, prolonged post operation, or post traumatic states• Produced microparticles and cultured adhesive cancer cells for screening drugs evaluating toxicity

• Cultured human cancer cells in disposable bioreactors and CSTRs• Assisted in experimentation, data analysis, and presentation of a mixing study for a scale-up project

Doctor Of Philosophy (Phd), Chemical And Biochemical Engineering

Activities and Societies: Biotech Training ProgramRelevant courses: Molecular Biology of Cells, Analytical Methods for Chemical.

B.S., Chemical-Biological Engineering

Activities and Societies: Undergraduate Research Opportunities Program (Langer Lab), Undergraduate Practice Opportunities Program, Korean.