Severin Wendelspiess

Severin Wendelspiess Email and Phone Number

Antibody Engineer, Senior Scientist @ Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Uitikon, ZH, CH
Severin Wendelspiess's Location
Uitikon, Zurich, Switzerland, Switzerland
About Severin Wendelspiess

Throughout my career, I have developed a history of success in protein engineering and antibody discovery, such as lead optimisation, protein purification, biophysical/binding characterisation, antibody identification/screening, and cell biology.I am a Molecular biologist/biochemist with solid expertise in immuno-oncology field. My experience enhanced my skills in conducting experiments, troubleshooting challenging issues, and creating appropriate solutions. Furthermore, I am adept at engaging in innovative assays to assist discovery and development projects. As a strategic expert, I am expert at recruiting, supporting, and supervising direct reports for organisational excellence. Moreover, I have track record of designing new ideas/strategies to build multiple platforms. I am an excellent communicator with proficiencies in fostering relationships with teams, colleagues, and seniors.My passion is working across research, preferably in the antibody discovery. Please feel free to contact me with any thoughts, comments, or questions about my work.

Severin Wendelspiess's Current Company Details
Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Jiangsu Hengrui Pharmaceuticals Co., Ltd.

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Antibody Engineer, Senior Scientist
Uitikon, ZH, CH
Severin Wendelspiess Work Experience Details
  • Jiangsu Hengrui Pharmaceuticals Co., Ltd.
    Antibody Engineer, Senior Scientist
    Jiangsu Hengrui Pharmaceuticals Co., Ltd.
    Uitikon, Zh, Ch
  • Glycoera Ag
    Senior Scientist Cmc Analytics
    Glycoera Ag Dec 2023 - Present
  • Hengrui Europe Biosciences Ag
    Antibody Engineer, Senior Scientist
    Hengrui Europe Biosciences Ag Aug 2022 - Dec 2023
    In this role, I develop the state-of-the-art laboratories and discovery platforms for newly developed research site in Zurich. I am involved in hiring, recruiting, and building a high-performing team to meet company's set objectives. Also, I coordinate group performance managing lead optimisation/protein engineering operations within the protein science department.My key contributions:• Gained excellent progress by overseeing all facets of technology platform development.• Designed lab from scratch by selecting appropriate tools/instruments.The site was closed due to restructuring by headquarters.
  • Cdr-Life Inc.
    Screening Expert Bei Cdr-Life Inc.
    Cdr-Life Inc. Oct 2021 - Aug 2022
    Horgen, Zurich, Ch
    During this time,I led operations of screening unit, encompassing entire antibody screening and hit characterisation process in order to ensure smooth running of operations. I identified binders against problematic targets, such as pMHC-complexes. Also, I build IP by improving phage display libraries to fully exploit rabbit repertoire.My key contributions:• Successfully completed projects while serving as key part of research steering committee.• Boosted team skills and capabilities by delivering exceptional services as team lead.• Enhanced throughput and binders' quality by deploying novel antibody discovery platform, encompassing immunisations, B cell sorting for single cell analysis, and NGS.• Conducted and optimised phage display campaigns according to needs of project.
  • Cdr-Life Inc.
    Discovery Scientist
    Cdr-Life Inc. May 2020 - Nov 2021
    Horgen, Zurich, Ch
    At this tenure, I used advanced phage display, humanisation, and lead optimisation strategies to upgrade antibody discovery platform. I arranged characterisation of antibody fragments using several cell and in vitro assays. Led efforts to improve screening, humanisation, and lead optimisation process with high-level of efficiency.My key contributions:• Delivered services in producing IP for utilisation of full rabbit IgG repertoire as main person.• Generated and optimised CD3-binding antibody with low, medium, and high affinities in two distinct forms (Fab and scFv).
  • The Janssen Pharmaceutical Companies Of Johnson & Johnson
    Scientist
    The Janssen Pharmaceutical Companies Of Johnson & Johnson Oct 2019 - Apr 2020
    Raritan, New Jersey, Us
    In this position,I supervised team members and organisation to confirm accurate and timely attainment of set objectives. I planned and executed experiments in range of areas, encompassing, medical research, protein science, and engineering.My key contribution:• Maximised throughput by coordinating protein production workflow from gene synthesis to characterisation.The site was closed due to restructuring by headquarters.
  • The Janssen Pharmaceutical Companies Of Johnson & Johnson
    Research Associate
    The Janssen Pharmaceutical Companies Of Johnson & Johnson May 2015 - Sep 2019
    Raritan, New Jersey, Us
    During this role,I performed the molecular biology/cloning tasks, such as plasmid creation, DNA sequence analysis, bacterial, and mammalian expression. I carried out protein purification by utilising Äkta systems, biophysical/stability characterisation of proteins (HPLC, DLS, nanoDSF, SDS-PAGE) and binding characterisation of proteins (ELISA, FACS, Biacore).My key contributions:• Followed/monitored projects from antibody screening up to developability.• Facilitated multiple projects in areas of Autoimmunity, Immuno-oncology, and Gene Editing.• Deployed various functional cell assays to obtain better insight activities of molecules on cellular level.
  • Roche Pharmaceuticals
    Labspecialist
    Roche Pharmaceuticals Jul 2010 - Apr 2015
    Switzerland 🇨🇭 , Ch
    In this time,I actively engaged with small molecules and peptides in lab. I spearheaded all facets of research projects related to physico-chemical properties within the group.My key contribution:• Built existing/new analytical assays/methods, including HPLC-MS, UV, CE, and Formulation stability testing.
  • University Of Hohenheim
    Wissenschaftlicher Mitarbeiter
    University Of Hohenheim Oct 2009 - Mar 2010
    Baden-Württemberg, De
    Determined quinone binding subunit of Na+-NQR. Membrane protein expression: cloning, expression  Purification: SEC, Affinity Chromatography  Characterisation: HPLC, SDS-PAGE, Western-Blot

Severin Wendelspiess Skills

Pharmaceutical Industry Biochemistry Biotechnology Physical Chemistry Molecular Biology Biology Laboratory Laboratory Skills Laboratory Automation Pharmacokinetics Chemistry Protein Chemistry Molekularbiologie Biochemie Proteinchemie Zellbiologie

Severin Wendelspiess Education Details

  • University Of Zurich
    University Of Zurich
    Biochemie

Frequently Asked Questions about Severin Wendelspiess

What company does Severin Wendelspiess work for?

Severin Wendelspiess works for Jiangsu Hengrui Pharmaceuticals Co., Ltd.

What is Severin Wendelspiess's role at the current company?

Severin Wendelspiess's current role is Antibody Engineer, Senior Scientist.

What schools did Severin Wendelspiess attend?

Severin Wendelspiess attended University Of Zurich.

What skills is Severin Wendelspiess known for?

Severin Wendelspiess has skills like Pharmaceutical Industry, Biochemistry, Biotechnology, Physical Chemistry, Molecular Biology, Biology, Laboratory, Laboratory Skills, Laboratory Automation, Pharmacokinetics, Chemistry, Protein Chemistry.

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