Séverine André, Phd Email & Phone Number

Taverny, Fr

Taverny, Fr

Development of a neuroprotective and neuroregenerative strategy dedicated to optic nerve injury- Lead R&D studies, from the design and the planification to results analysis- Manage regulatory needs for the use of laboratory animals - Supervise team work and lab activities- Collaborate with service providers, from the design to results restitution* Promising results obtained thanks to the collaboration with the mass spectrometry platform of the Institut Pasteur* Successful discussions with scientific experts, biostatisticians and ethical commitees to prepare project modification for animal use* Authorization obtained from the Ministère de l’Enseignement Supérieur et de la Recherche et Innovation after soumission of project modification for animal use* Experimental results leading to patent deposit in 2024* Preparation of presentations for external meetings for the start-up and study reports for procedure standardizationTechnical skills: ELISA, AAV2 manipulation, cell culture, culture ex vivo, immunofluorescence, animal handling, eye surgery, tissue prelevement and preparation, histology, western blot

Ville De Paris, Île-De-France, France

- Perform and analyze experiments- Present results in follow-up meetings

- Set up and supervise practical works in cell biology- Manage 3-4 student groups in parrallel as well as following sessions- Communicate effectively guidelines and expectations (written and oral)- Evaluate theorical and practical knowledge

Title of the thesis: Development of a molecular therapeutic strategy for Alzheimer's disease by the modulation of an isoform of phospholipase Thesis supervisor: Carmen BurteaHead of laboratory: Sophie Laurent- Conduct research project, from technique implementation to results analysis- Write scientific papers, funding requests and abstracts- Present results during international scientific meetings- Supervise master's students* 3 papers as first author :André et al., J Alzheimers Dis Rep. 2023 Dec 29;7(1):1395-1426André et al., Biology 2020, 9, 161André et al., J. Alzheimers Dis. 2017, 60(4) :1547-1565* 2 oral presentations and 14 poster presentations* 1 patent as inventor (WO2021116079)* 3 grants obtained * 4 students supervisedTechnical skills : phage display, including ELISA (dissociation constants, industrial kits), bacteria manipulation, DNA purification and sequencing, cell culture, viability assay, immunofluorescence, animal handling, tissue prelevement and preparation, histology, behavioural testing (Barnes maze), NMR measurements, MRI on small animals with contrast agents, FLI, PCR (detection of mycoplasma)

Birmingham, Royaume-Uni

Use of nanocarriers for penetrating the blood-brain barrier and delivering to central nervous systemTechniques: design and characterization of nanoparticles, primary cell culture (PMBECs), immortalized cell culture (PBEC and C6), confocal microscopy, MTT assays, Western blotting (protein extraction, electrophoresis)

Doctor Of Philosophy - Phd, Biomedical Sciences, General

Title of the thesis: Development of a molecular therapeutic strategy for Alzheimer's disease by the modulation of an isoform.

Master'S Degree, Biomedical Sciences, General, High Distinction

Key courses: Management Awareness of Technological Innovation Projects, GMP-GLP-Validation, Intellectual Properties, Risk assessment.

Bachelor'S Degree, Biomedical Sciences, General, Satisfaction