Severin Lechner Email & Phone Number

Vienna, Austria

Wien, Österreich

Freising, Bayern, Deutschland

München, Bayern, Deutschland

At the Chair of proteomics and bioanalytics:- Drug target deconvolution via chemical proteomics- Selectivity profiling of drug targets off-targets- Investigation of DNA-protein and RNA-protein interactions by LC-MS/MS-based proteomics.Publications:1. Lechner, S., et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol (2022). https://doi.org/10.1038/s41589-022-01015-52. Lechner, S., Steimbach, R. R., Wang, L., Matthias, P., Miller, A. K., Médard, G., Kuster, B.Chemoproteomic target deconvolution of lipoic acid reveals Histone Deacetylases as the maintargets. Preprint at Research Square (2022). https://doi.org/10.21203/rs.3.rs-2277181/v13. Steimbach, R. R., Herbst-Gervasoni, C. J., Lechner, S., et al.,Aza-SAHA Derivatives AreSelective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation andPhenocopy HDAC10 Knockout. Journal of the American Chemical Society 144 (41), 18861-18875 (2022). https://doi.org/10.1021/jacs.2c050304. Glas, C., Lechner et al., Development of hetero-triaryls as a new chemotype forsubtype-selective and potent Sirt5 inhibition. Eur J Med Chem.; 240:114594 (2022).https://doi.org/10.1016/j.ejmech.2022.114594.5. Zecha, J. et al. Decrypting drug actions and protein modifications by dose- and time-resolved proteomics. Science 380, 93-101 (2023).

Research: Immune Biology

Master Of Science (M.Sc.), Biochemistry, 1,1

During my masters program in biochemistry I've been focusing on molecular medicine and biophysics. In my Master's Thesis at the chair.

Biochemistry

Exchange Semester in Sweden with focus on Protein Engineering and RNA Biology.

Bachelor Of Science (B.Sc.), Molecular Biotechnology, 1,7

Activities and Societies: Active member of the Bavarian mountain rescue service (Bergwacht Bayern)Bachelor Thesis: Synthesis.

Doktor (Ph.D.), Chemical Proteomics, Summa Cum Laude (With Highest Honor)