Established in 2006, Scisco Genetics Inc. is accredited by the American Society for Histocompatibility and Immunogenetics (ASHI), the Clinical Laboratory Improvement Amendments (CLIA) program, and the Washington State Department of Health. Fast and accurate high resolution genotyping of complex immune regions is critical to improving transplant outcomes and understanding disease associations.Scisco Genetics is dedicated to:• Providing high quality sequence-based typing solutions and services for complex immune gene systems, including HLA and KIR.• Enabling Next Generation Sequencing technology in clinical laboratories that support transplant programs.• Continuous quality improvement in sequencing technology and software analysis tools.Key Responsibilities include:• Clinical Guidelines development• Technical Services and Accreditation• Quality and Compliance - Maintaining quality control and quality assessment programs, ensuring, resolving technical problems, ensuring corrective action when test systems deviate from established performance • Evaluation of new equipment and tests - validation of new testing technologies and platforms, determining acceptable levels of analytical test performance• The competency of laboratory personnel, including participation in proficiency testing programs, training in methodologies, and continuing education.

Founded in 1947, Group Health Cooperative is a consumer-governed, nonprofit health care system that coordinates care and coverage. Based in Seattle, Wash., Group Health and its subsidiary health carriers, Group Health Options, Inc. and KPS Health Plans, serve more than half a million residents of Washington state and IdahoAppointed to be responsible for technical and clinical services, overall laboratory quality, and compliance performance within the internal and external delivery system. To leverage the technical expertise of a team of pathologists, other practitioners and industry colleagues to lead the design, development, and implementation of department strategies, and work with business operations leaders to manage strategies deployments. Group Health has 22 laboratory locations in Washington. Key responsibilities included:• Test Utilization Management, • Clinical Guidelines development,• Technical Services • Quality and Compliance• Evaluation of new equipment and tests • Business owner of the Laboratory Information System (LIS)

The clinical laboratory supports physicians, scientists and clinical staff involved in treatment and research for patients with cancer at the FHCRC; the Center is known for its pioneering work in bone marrow transplantation. “The Hutch” is a not-for-profit teaching and scientific research center, working with patients and supporting research aimed at improving treatment outcomes for people with cancer or with critical organ failure.I was responsible for overall operation and administration of the Clinical Immunogenetics laboratory, including technical and scientific oversight, training of personnel, accuracy of testing, reporting, and regulatory compliance. My responsibilities included: • Selecting test methodologies, development and validation of new testing technologies and platforms, determining acceptable levels of analytical test performance, development and validation of standard processes for workflow in the laboratory, and between the laboratory and stakeholders• Maintaining quality control and quality assessment programs, ensuring, resolving technical problems, ensuring corrective action when test systems deviate from established performance • Providing advice in support of donor search and selection processes and ensuring that consultation is available to the laboratory's clients relating to the quality of test results and their interpretation• The competency of laboratory personnel, including participation in proficiency testing programs, training in methodologies, and continuing education.• Interactions with stakeholder clinical programs and services

The Stanford Histocompatibility Laboratory supports the Histocompatibility, Immunogenetics and Disease Profiling testing needs of all transplant programs at the Stanford Medical Center and at the Lucille Packard Children’s Hospital at Stanford, including liver, kidney, pancreas, heart, lung, small bowel and human stem cell (HSC/BMT) transplantation. The transplant programs at Stanford Hospital & Clinics have earned a number of distinctions including performing the first adult heart transplant in the US, the first heart-lung transplant in the world and have outstanding outcomes for both patient and graft survival, The Bone Marrow Transplant program at Stanford performs auto and allo transplantations for approximately 200 adult patients/year. My responsibilities included:• Involvement in all aspects of the performance of clinical tests and interpretation of results • Providing first call for assay results where technologists had difficulty interpreting the data• Identifying individual problems and defining strategies for resolution• Conveying relevant information to clinicians • Providing consultations to physicians for platelet transfusion support and advice on the use of compatible donors• Providing literature reviews • Delivering lectures on transplantation for Clinical training at various Bay Area Hospitals.• Coordinating didactic and clinical rotations for Residents and Fellows

The Immunogenetics and Transplantation Laboratory (ITL) provides specialized diagnostic services for allogeneic transplantation and conducts related research. The laboratory provides support for blood, bone marrow, kidney, pancreas, liver, heart, lung, small bowel, and cornea transplantation. UCSF has performed more kidney transplants than any other hospital in the world. About 1,200 patients/ year are evaluated as potential transplant candidates with more than 300 kidney transplants performed/year. The ITL is a national reference laboratory, a referee laboratory for the ASHI proficiency testing program, a NMDP contract laboratory, a core laboratory for the NIH Immune Tolerance Network, and a participant in several national clinical trials. The laboratory also conducts basic research and provides educational programs for health care professionals. The laboratory is not-for-profit and is owned and operated by the University of California, San Francisco.Laboratory and Clinical Experience:• Provided consultations on sensitization and screening histories, as well as the cross-match results of high risk solid organ (live donor) transplant candidates • Modified a lab procedure utilizing pronase treated lymphocytes in flow cytometry • Developed Quality Assurance/ Quality Monitoring (QA/ QM) monitoring forms for compliance with CLIA, CA state and ASHI regulations • Performed monthly and quarterly monitoring of QA/QM indicators • Observed trends and evaluated the effectiveness of corrective actions • Served on a subcommittee for compliance with the National Society Standards and updates to CLIA regulations codified in 2004 • Served on the National Society’s Quality Assurance/ Standards Committee that reviews and updates Quality Assurance/ Standards

Laboratory Experience:• Characterization of the gene disrupted in the Roi mutation in D. melanogaster • Characterized the roles played by the Src-family kinases in signaling and effector functions in immune cells. • Provided the first evidence that resting murine neutrophils express on their surface a novel integrin (alpha4). • First demonstrated that the Src kinase Lyn plays an inhibitory role in integrin and cytokine signaling in myeloid cells • First demonstrated that the ITIM-containing receptor PIR-B is involved in inhibiting downstream integrin and cytokine signaling in myeloid cells • Mapped the appropriate regions of the mouse Lyn and Fgr genes and constructed vectors for the targeted insertion of kinase-inactive and floxed mutant alleles in embryonic stem cells.• Investigated the role of Faf1 (fas-associated factor 1) in autoimmune disease. Activities: Served on the steering committee of ‘Women in Life Sciences’ (WILS) 2001-2003a UCSF women run organization, which serves as a networking and support structure for UCSF women scientists at all levels of their career