Lipid Synthesis and Delivery Chemistry

Independently working as a medicinal chemist on NASH and oncology drug discovery and development programsFacilitating conversations with CROs for both external chemistry and biology project setupsLed and completed the set-up of the new chemistry research laboratory with a limited budget and resourcesAssisting with the writing of scientific grant proposals for new research programs

Involved in research of novel oligosaccharides that can control the metabolic profile of the microbiome. Relied on implementation of synthetic chemistry, purification, and troubleshooting skillsSmall molecule synthesis; aqueous-based catalyst synthesis including protecting group carbohydrate chemistrySpearheaded overall synthesis and purification of enzyme-catalyzed carbohydrate moleculesAided both domestic & international chemistry CRO setup and smooth execution of projects with high reproducibility

Delivered a well-organized, planned ‘Drug Discovery Project’ that involved design and synthesis of targets around a lead organo-selenium small molecule compound. Demonstrated excellence in setting-up new laboratory space and performed as a part of a skilled team, equipped with technical knowledge of using and maintaining the latest laboratory instruments. Designed & initiated synthesis of compounds/intermediates with development of a Reverse Phase purification process Performed custom organic synthesis of small molecule compounds (enzyme inhibitors, receptor antagonists andsynthetic intermediates) for pharmaceutical and biotechnology firms

Headed synthesis of an array of compounds for establishing a built strong connection between allosteric activity and compound structure. Delivered a research project, “Synthesis and In Vitro Characterization of Allosteric Modulators of the α7 Nicotinic Acetylcholine Receptors” Excelled in identifying, synthesizing and purifying novel organic compounds acting as Positive Allosteric Modulators of α7 Nicotinic-receptors, implicated in neuro-degenerative diseases such as Alzheimer's and Schizophrenia

Strategized, planned and initiated designing & synthesis of cell-permeable small molecule chemical probes for performing in-depth NMR studies Independently conducted synthesis of a set of small molecules conjugates - determining overall suitability for in-cell chemical proteomic profiling and target identification