• Lead a team of managers, leads, and contributors responsible for scientific data modeling and integration intoDiscovery and Clinical products.• Successfully coached individual contributors to senior manager level roles, helping them realize career developmentplans.• Maintain and test content within the QIAGEN Knowledge Base to support quarterly and weekly releases.• Supervised development and optimization of machine learning (ML) methods used for literature selection andintegration into products.• Work with product owners, project managers, and outside customers to develop requirements for scientific featuredevelopment.• Develop and test protocols and SOPs for content acquisition to ensure it is consistent with requirements.• Provide end-to-end testing of new features, enhancements, and fixes to ensure they are scientifically consistent withthe intended uses.• Established scientific testing group for QIAGEN QCI-I and integrated this function within the existing productdevelopment and release framework.• Revamped existing test framework to reduce redundancy.• Updated and created workflows that are more efficient to facilitate testing for on-time releases.• Integrated scientific testing personnel within overall testing groups.• Oversaw the Quality Management Representative and Risk Manager for the ISO 13485/IVDR team.

Core team member on products and work directly with Product Owners and Product Managers on feasibility investigations and requirements for new features and enhancements.Project team member for numerous customer-specific services engagements, responsible for engaging customer, developing and clarifying requirements, and delivering on-time, well-tested implementations.Responsible for implementation of ISO 9001 Quality Management System for content acquisition and software development.Work with team members to develop and realize career development plans including growth from individual contributor to manager.Manage a team of nine scientists responsible for development of content requirements, implementation, and testing for three QIAGEN Bioinformatics products: Ingenuity Pathway Analysis (IPA), Ingenuity Variant Analysis (IVA), and QIAGEN Clinical Insight-Interpret (QCI-I).• Work with product owners, project managers, and outside customers to develop requirements for scientific feature development.• Perform investigations, provide domain expertise, and act as subject-matter experts for QIAGEN Bioinformatics products. Oversee and manage a team of eight bioinformaticians responsible for data modeling and content pipeline for IPA, IVA, QCI-I, and OmicSoft ArraySuite products.• Maintain and test content within the QIAGEN Knowledge Base to support quarterly and weekly releases.• Design and implement modeling changes for new product features and enhancements. • Supervised development and optimization of machine learning (ML) methods used for literature selection.Established scientific testing group for QIAGEN QCI-I and integrated this function within the existing product development and release framework.• Updated and created workflows that are more efficient to facilitate testing for on-time releases.• Integrated scientific testing personnel within overall testing groups. • Provide end-to-end testing of new features, enhancements, and bug fixes.

• Improved oncology drug approval, guideline, and clinical trial coverage based on customer requirements to support QCI-I application.• Developed a revised finding model for support of multiple variants for the mutation extraction project. Coordinated implementation with project management, curation group, and application developers, resulting in on-time completion.• Created a model for computational export of genetic dependencies for disease/tumor classes, underspecified variants, fusion protein(s), and copy number variants.

• Responsible for treatment related and pharmacogenetics related exports as well as Pathway Knowledge Base/OpenBEL quarterly exports including customer communication and support.• Experience with Python, Perl, Java, SQL, and ask/tell ontology query language including writing imports of external databases for incremental update of content and working with various scientific APIs (PubMed, PubChem, DailyMed) and other APIs such as Google Docs.• Experience in working with chemoinformatics libraries: Open Babel (Java), CDK (Java), and PerlMol (Perl).• Worked in an agile programming environment supported with TargetProcess, JIRA/Confluence, Hudson/Jenkins, and Apache Subversion (SVN).

• Co-initiated the JAK3 program. Started chemistry efforts, then guided lead optimization efforts in two templates improving selectivity against JAK family kinases and overall panel selectivity, with increased bioavailability.• Pursued lead-optimization to identify a backup to PRT062607. Identified modifications which imparted decreased off-target activity and improved whole-blood activity. • Coordinated patent writing and the drafting of patent claims.• Worked to start the in-house automated screening group to facilitate optimization of on-target and off-target kinase activity using Z-LYTE and ultraLANCE assay systems.• Responsible for administration of the discovery database (Accelrys AEI) and query / browsing software (Dotmatics Browser & Vortex).

• Performed medicinal chemistry optimization of a small molecule inhibitor of P2Y12 leading to the selection of PRT060128 (elinogrel).• In the elinogrel backup program explored non-sulfonylurea motifs of lead P2Y12 templates which led to the identification of backup candidates PRT060592 and PRT060674. • Identified a novel Syk kinase inhibitor template which was then optimized to increase plasma based cellular potency and improved clearance and half-life, leading to the selection of PRT062070 as a preclinical candidate.

• Performed medicinal chemistry optimization of three structurally distinct templates for the Factor Xa program; developed SAR, modified templates to optimize efficacy, toxicological and pharmacokinetic characteristics.• Imported and implemented automated purification systems (HPLC and MPLC), coordinated laboratory equipment responsibilities.

• Managed all chemistry aspects of template optimization and coordinated pharmacological testing of inhibitors which led to the discovery of a potent, selective and patentable orally active small molecule Factor Xa inhibitor.

• Performed medicinal chemistry optimization of lead compounds for potency, efficacy, and bioavailability against cardiovascular and inflammation targets: PAI-1 (serpin), Sphingomyelinase (phosphodiesterase), Lipoxin A4 receptor.• Successfully developed and prototyped multi-step solid phase and solution phase libraries for parallel synthesis.• Performed initial process research of drug candidate optimizing reactions and eliminating chromatographic steps• Worked with 500+ gram material quantities.• Validated small molecule drug screening hits by performing initial structural activity relationships.