Sheelagh Frame

Sheelagh Frame Email and Phone Number

Head of Biology @ Ubiquigent Ltd
Dundee, GB
Sheelagh Frame's Location
Dundee, Scotland, United Kingdom, United Kingdom
Sheelagh Frame's Contact Details

Sheelagh Frame work email

Sheelagh Frame personal email

n/a
About Sheelagh Frame

Sheelagh is CSO of the Dundee based biotech company, Ubiquigent, and has over 25 years’ experience in oncology drug discovery and development. She joined Ubiquigent in 2018 as Head of Biology taking responsibility for the company’s operations in Dundee becoming CSO in 2021. During this period, Sheelagh has grown the Ubiquigent team and laboratory operations, expanded the suite of assays within the company’s Drug Discovery Screening Platform, managed client relationships and supported the growth in the revenue-generating services and the development of an IP portfolio of novel deubiquitylase (DUB) enzyme modulators.Whilst in her previous roles, Sheelagh gained significant expertise in drug discovery and development, mainly in oncology, but also spanning autoimmune/inflammation, diabetes and rare diseases, working with international research groups, clinical investigators and KOLs. She looks forward to leveraging her experience in translational research & drug development alongside Ubiquigent’s expertise in modulating the deubiquitinase (DUB) enzyme family to exploit the ubiquitin-proteasome pathway to address unmet medical needs.Sheelagh holds a BSc Hons in Molecular Biology from the University of Edinburgh and a PhD in Medicine from the Beatson Institute for Cancer Research, affiliated to the University of Glasgow.

Sheelagh Frame's Current Company Details
Ubiquigent Ltd

Ubiquigent Ltd

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Head of Biology
Dundee, GB
Website:
ubiquigent.com
Employees:
5
Sheelagh Frame Work Experience Details
  • Ubiquigent Ltd
    Head Of Biology
    Ubiquigent Ltd
    Dundee, Gb
  • Ubiquigent Ltd
    Chief Scientific Officer
    Ubiquigent Ltd Jun 2021 - Present
    Dundee, Scotland, Gb
  • Ubiquigent Ltd
    Head Of Biology
    Ubiquigent Ltd Jul 2018 - Present
    Dundee, Scotland, Gb
  • Cyclacel Limited
    Program Manager - Oncology & Autoimmune/Inflammation
    Cyclacel Limited 2002 - 2018
    Dundee, Scotland, Gb
    PROGRAM MANAGER, Seliciclib – Oncology and Autoimmune & InflammationPROGRAM MANAGER, CYC140 PLK programTRANSLATIONAL RESEARCH TEAM MANAGER – CDK and PLK programsTRANSLATIONAL SCIENTIST PROJECT LEADER, CDK program
  • University Of Dundee
    Senior Postdoctoral Fellow
    University Of Dundee 1999 - 2002
    Dundee, Angus, Gb
    Division of Signal Transduction Therapy· Biochemical and molecular analysis of the substrate specificity and regulation of GSK3 in the insulin and Wnt signalling pathways. Identification of a specific substrate binding site in the catalytic domain of GSK3, differentially utilised by primed substrates of GSK3 involved in the insulin signalling pathway· Project initiated with fellow postdoc as a result of therapeutic concern that long-term administration of GSK3 inhibitors in the treatment of Type II diabetes or neurodegenerative disease may be oncogenic. Hypothesised that compounds interacting with the phosphate binding site may be an attractive alternative to ATP-competitive inhibitors for the management of Type II diabetes due to selective inhibition of kinase activity towards specific subset of substrates in the insulin signalling pathway· Demonstrated proof of principle in vitro with phospho-peptides and designed appropriate in vitro and cell-based assays to identify small molecule compounds by high-throughput screening· COLLABORATION with GlaxoSmithKline on the biochemical analysis of a component of the Wnt signalling pathway
  • Onyx Pharmaceuticals, Inc., An Amgen Subsidiary
    Postdoctoral Research Scientist
    Onyx Pharmaceuticals, Inc., An Amgen Subsidiary 1997 - 1999
    South San Francisco, Ca, Us
    · Responsible for target validation of PI3-kinase/PKB pathway as a candidate for anti-cancer therapy within the collaboration between the "Ras" team at Onyx Pharmaceuticals and Bayer Pharmaceuticals· Involved in the design, optimisation and performance of cell-based assay to test potential raf kinase inhibitors from in vitro high throughput screening program at Bayer Pharmaceuticals (leading to development of Nexavar, approved for renal cancer)· Interactions with colleagues at Bayer Pharmaceuticals and members of the cell cycle and adenovirus programs; attendance at group meetings of ras and cell cycle groups (the latter led to development of palbociclib – CDK4/6 inhibitor approved for breast cancer)

Sheelagh Frame Education Details

  • University Of Glasgow
    University Of Glasgow
    Medicine
  • The University Of Edinburgh
    The University Of Edinburgh
    Molecular Biology

Frequently Asked Questions about Sheelagh Frame

What company does Sheelagh Frame work for?

Sheelagh Frame works for Ubiquigent Ltd

What is Sheelagh Frame's role at the current company?

Sheelagh Frame's current role is Head of Biology.

What is Sheelagh Frame's email address?

Sheelagh Frame's email address is sh****@****ent.com

What schools did Sheelagh Frame attend?

Sheelagh Frame attended University Of Glasgow, The University Of Edinburgh.

Who are Sheelagh Frame's colleagues?

Sheelagh Frame's colleagues are Steven Liness.

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