Sheena Mcgowan, Phd Email and Phone Number
A versatile research and development leader with deep antimicrobial experience and broad drug development expertise. Passionate about building and nurturing, dynamic, high-performing teams to translate cutting-edge technologies into new products and therapeutics. I have over 20 yearsโ experience in antimicrobial drug discovery, structure-based drug design, medicinal chemistry, structural biology, biochemistry from concept to lead molecule. I can build cross-functional teams and provide an essential link between scientists, collaborators and stakeholders to deliver products.I built a successful career as a tenured PI at Monash University (Australia) before choosing to transition to industry to pursue a strong desire to deliver real world solutions. I am widely published with >85 research papers and >130 structures generated in the protein databank. I have developed broad communications skills with experience in dilutive and non-dilutive funding applications, presentations to CEO, boards, research & development committees and at international scientific conferences. As a senior member of an Australian โGroup of 8โ University, I held multiple critical leadership roles that spanned academic departments, discovery centres and cross-faculty positions, leveraging an extensive skillset in strategy, operations and management.In my previous position, I established and led a global structure-based drug design program that delivered a new compound class to the global product developer. I raised $AUD12M, built and led a matrixed team (academic, VC and philanthropic stakeholders; chemistry, biology, DMPK, CRO scientists; product developers). The outcomes of this program were target ID, MoA characterization and target validation; hit discovery > hit-to-lead optimization; compound design and development; assay development and transition to high-throughput and computational screens; DMPK optimization; engagement with global product developer for transition to their pipeline.
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Termeer FellowThe Termeer FoundationSan Diego, Ca, Us -
PrincipalAurora Bioservices Llc Sep 2024 - PresentSan Diego, California, United StatesAurora Bioservices LLC provides contract R&D and consulting services for the Life Sciences, Biotechnology, and Pharmaceutical industries serving both small and large sized organizations. Particular expertise in structural biology, drug discovery, structure-based drug design, microbiology and biochemistry. Specific deliverables include:- Structural biology (crystallography, cryo-EM, computational) & structure-based drug design (ligand design, SAR).- Assay development and screening for hit discovery & hit-2-lead.- Anti-infective / anti-microbial resistance subject matter expertise.- Strategic development and planning for transition from early stage discovery.- Project plans and leadership - Outreach to KOLs, other scientists, and customers.- Funding and Investment (including dilutive and non-dilutive; pitch preparation).- Definition of Product and Product Development.
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Strategic AdvisorStealth Biotech Start-Up Jul 2024 - PresentSan Diego, California, United StatesPartnering with scientific founders to define early stages of growth and development.Advice and partnership in:- Market Analysis and Positioning- Strategic Planning for R&D Package- Funding and Investment (including dilutive and non-dilutive; pitch preparation)- Definition of Product and Product Development- Risk Management
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Senior Consultant And Advisory Board MemberPtng Consulting 2020 - PresentProviding specialized solutions in structural biology, protein engineering and design, and small molecule discovery and design. -
Laboratory Head And Associate Professor (Tenured), Structural MicrobiologyMonash University Jan 2011 - Present๐๐๐๐, ๐๐ญ๐ซ๐ฎ๐๐ญ๐ฎ๐ซ๐๐ฅ ๐๐ข๐๐ซ๐จ๐๐ข๐จ๐ฅ๐จ๐ ๐ฒThe McGowan lab is a multidisciplinary team with expertise in structural biology, biochemistry, medicinal chemistry, drug design and computational biology. We study therapeutically important microbial proteins at the atomic level to understand their function.Using this data, we aim to discover lead molecules and guide drug development. ๐๐๐ฃ๐จ๐ซ ๐ฉ๐ซ๐จ๐ ๐ซ๐๐ฆ๐ฌ๐๐ฎ๐ช๐ฏ๐ฐ๐ฑ๐ฆ๐ฑ๐ต๐ช๐ฅ๐ข๐ด๐ฆ ๐ช๐ฏ๐ฉ๐ช๐ฃ๐ช๐ต๐ฐ๐ณ๐ด ๐ข๐ด ๐ฏ๐ฆ๐ธ ๐ข๐ฏ๐ต๐ช๐ฎ๐ข๐ญ๐ข๐ณ๐ช๐ข๐ญ๐ด- Program outcomes include Target ID, MoA characterization and target validation; hit discovery > hit-to-lead; compound design and development; assay development + transition to HTS and computational screens; DMPK.- Top compound recognised as on-target by Medicines for Malaria Venture (MMV1557817).๐๐ข๐ณ๐จ๐ฆ๐ต๐ช๐ฏ๐จ ๐ด๐ฑ๐ฐ๐ณ๐ถ๐ญ๐ข๐ต๐ช๐ฐ๐ฏ ๐ต๐ฐ ๐ฑ๐ณ๐ฆ๐ท๐ฆ๐ฏ๐ต ๐. ๐ฅ๐ช๐ง๐ง๐ช๐ค๐ช๐ญ๐ฆ ๐ช๐ฏ๐ง๐ฆ๐ค๐ต๐ช๐ฐ๐ฏ ๐ณ๐ฆ๐ค๐ถ๐ณ๐ณ๐ฆ๐ฏ๐ค๐ฆ - Inhibition of key proteins in the sporulation pathway blocks spore formation and prevents reccurence in animal models. - Nature Micro, 2019; J Med Chem 2024๐๐ฆ๐ง๐ช๐ฏ๐ช๐ฏ๐จ ๐ฏ๐ฆ๐ธ ๐ข๐ฏ๐ต๐ช๐ฃ๐ข๐ค๐ต๐ฆ๐ณ๐ช๐ข๐ญ ๐ต๐ฐ๐น๐ช๐ฏ๐ดโข Acinetobacter baumannii (Ab) uses protein toxins in inter-bacterial warfare to persist in healthcare environments.โข We characterize the structure & function of new toxins and how Ab deploys them against other bacteria.๐๐ฆ๐ท๐ฆ๐ญ๐ฐ๐ฑ๐ช๐ฏ๐จ ๐ข ๐ฏ๐ฆ๐ธ ๐ฆ๐ฏ๐ป๐บ๐ฎ๐ฆ ๐ค๐ญ๐ข๐ด๐ด ๐ข๐ด ๐ค๐ญ๐ฆ๐ข๐ฏ๐ช๐ฏ๐จ ๐ข๐จ๐ฆ๐ฏ๐ต๐ด.โข We exploit bacteriophage-encoded enzymes to disarm Klebsiella pneumoniae.โข Our goal is to add stable, active enzymes to hospital-grade disinfectants.๐๐ฎ๐ญ๐๐จ๐ฆ๐๐ฌ> 85 peer-reviewed publications (inc. Nature Micro, PNAS; eLife; EMBO J; mBio & J Med Chem).Funding ( ~ $15M) through competitive grants as well as private and public partners (inc MMV, Bill and Melinda Gates Foundation, Lgenia, HitGen, Gingko Bioworks)Supervised 20+ graduate students; formal University teaching (~1000 students/yr) -
Deputy Head Of Department, Department Of Microbiology, Monash UniversityMonash University Jun 2021 - Nov 2023Co-led vision and strategy for department (19 laboratories; ~ 220 staff / students; annual OpEx ~ $AUD15M) to ensure research excellence (publications in top tier journals, engagement with centres of research excellence, foundation member of other larger University and global initiatives). Undertook conflict resolution and performance development and management for senior staff. ๐๐๐๐ซ๐ฎ๐ข๐ญ๐๐ ๐๐ง๐ ๐๐๐ฏ๐๐ง๐๐๐ ๐ก๐ข๐ ๐ก๐ฅ๐ฒ ๐ฌ๐ค๐ข๐ฅ๐ฅ๐๐ ๐ฌ๐๐ข๐๐ง๐ญ๐ข๐ฌ๐ญ๐ฌ. ๐๐ฆ๐ค๐ถ๐ณ๐ฆ๐ฅ ๐ต๐ธ๐ฐ ๐ฏ๐ฆ๐ธ ๐ง๐ข๐ค๐ถ๐ญ๐ต๐บ ๐ฑ๐ฐ๐ด๐ช๐ต๐ช๐ฐ๐ฏ๐ด.- Wrote a successful business case based on data of teaching loads to secure additional OpEx. - Actively recruited outstanding, competitive talent, involved in appointment process and negotiation of support packages.๐๐ฆ๐ฏ๐ต๐ฐ๐ณ๐ฆ๐ฅ ๐ข๐ฏ๐ฅ ๐ฆ๐ญ๐ฆ๐ท๐ข๐ต๐ฆ๐ฅ ๐ซ๐ถ๐ฏ๐ช๐ฐ๐ณ ๐ต๐ข๐ญ๐ฆ๐ฏ๐ต. - Initiated and ran an โEmerging Leadersโ program to empower our brightest mid-career scientists to achieve their career goals. - The program had 4 candidates who each secured senior, independent positions within 18 months. ๐๐ก๐๐ง๐ ๐ ๐ฆ๐๐ง๐๐ ๐๐ฆ๐๐ง๐ญ. Laboratory and office space is a constant pain point for Universities! Tasked with ensuring each team had access to the necessary infrastructure (across multiple buildings) to ensure success. ๐๐ญ๐ฆ๐ข๐ณ ๐ค๐ฐ๐ฎ๐ฎ๐ถ๐ฏ๐ช๐ค๐ข๐ต๐ช๐ฐ๐ฏ. - Undertook open consultation to establish open dialogue with laboratory PIs re their needs.๐๐ณ๐ข๐ฏ๐ด๐ฑ๐ข๐ณ๐ฆ๐ฏ๐ค๐บ ๐ฐ๐ง ๐ฑ๐ณ๐ฐ๐ค๐ฆ๐ด๐ด.- Implemented a large scale move of equipment and some teams. Organised support for physical move(s).- Feedback from colleagues was positive and new space arrangements functional. ๐๐ฌ๐ฌ๐๐ญ ๐๐ฏ๐๐ฅ๐ฎ๐๐ญ๐ข๐จ๐ง ๐๐ง๐ ๐๐ฎ๐๐ข๐ญ ๐ญ๐จ ๐๐ง๐ฌ๐ฎ๐ซ๐ ๐๐๐๐ฎ๐ซ๐๐ญ๐ ๐๐๐ฉ๐๐ฑ. After commencing my role, I realised there was no asset register and no forecast for CapEx. ๐๐ฐ๐ฎ๐ฑ๐ญ๐ฆ๐ต๐ฆ๐ฅ ๐ข๐ด๐ด๐ฆ๐ต ๐ข๐ถ๐ฅ๐ช๐ต.- Provided data for accurate CapEx forecast. Prevent downtime due to equipment failure or maintenance. -
Director Industry Engagement, Monash Biomedicine Discovery InstituteMonash University Nov 2019 - Aug 2023Melbourne, Victoria, AustraliaThe Monash Biomedicine Discovery Institute (BDI) incorporates over 120 research teams committed to global health priorities. With over 700 staff and students and an annual research income of over $AUD65M, the BDI is one of the largest and highest quality research institutes in the southern hemisphere. The BDI Industry Engagement (IE) team supported project and alliance management; education and outreach; engagement and networking.Activities include- Liaison between researchers and technology transfer office.- Education and outreach for early career researchers.- Events to raise engagement between researchers and industry stakeholders.- Networking events.- Recruitment and career advice. -
Senior DirectorReplay Aug 2023 - Jul 2024San Diego, California, United StatesLed product & project management for Genome Writing, one of three core pillars of the company, to define vision, killer application, specifications, and act as voice of customer for Replayโs genome writing service.๐๐ฆ๐ง๐ช๐ฏ๐ฆ๐ฅ ๐ข๐ฏ๐ฅ ๐ฆ๐ท๐ฐ๐ญ๐ท๐ฆ๐ฅ ๐ญ๐ฐ๐ฏ๐จ-๐ต๐ฆ๐ณ๐ฎ ๐ฑ๐ณ๐ฐ๐ฅ๐ถ๐ค๐ต ๐ท๐ช๐ด๐ช๐ฐ๐ฏ.- Identified areas for innovation and differentiation.- Defined OKRs for product technology.๐๐ณ๐ฐ๐ต๐ฆ ๐ฏ๐ฐ๐ฏ-๐ฅ๐ช๐ญ๐ถ๐ต๐ช๐ท๐ฆ ๐ง๐ถ๐ฏ๐ฅ๐ช๐ฏ๐จ ๐ข๐ฑ๐ฑ๐ญ๐ช๐ค๐ข๐ต๐ช๐ฐ๐ฏ๐ด (๐๐๐๐-๐; ๐๐๐๐; ๐๐๐๐). - Successful ARPA-H expression of interest; invitation to full proposal ($27M).๐๐ณ๐ฐ๐ด๐ด-๐ง๐ถ๐ฏ๐ค๐ต๐ช๐ฐ๐ฏ๐ข๐ญ ๐ญ๐ฆ๐ข๐ฅ๐ฆ๐ณ๐ด๐ฉ๐ช๐ฑ. - Transitioned 7 scientists from operating as an academic group to matrixed team. ๐๐ญ๐ฆ๐ท๐ข๐ต๐ฆ๐ฅ ๐ฑ๐ณ๐ฐ๐ฎ๐ช๐ด๐ช๐ฏ๐จ ๐ซ๐ถ๐ฏ๐ช๐ฐ๐ณ ๐ต๐ข๐ญ๐ฆ๐ฏ๐ต. - Promoted senior scientist to first technical leadership role.๐๐ณ๐จ๐ข๐ฏ๐ช๐ป๐ฆ๐ฅ ๐ฐ๐ฑ๐ฆ๐ณ๐ข๐ต๐ช๐ฐ๐ฏ๐ข๐ญ ๐ด๐ค๐ข๐ง๐ง๐ฐ๐ญ๐ฅ๐ด ๐ง๐ฐ๐ณ ๐ฆ๐ง๐ง๐ช๐ค๐ช๐ฆ๐ฏ๐ค๐บ.- Implemented team productivity tools for improved communication and project management.- Coordinated change in data management tools for secure data storage.- Produced policies to steward engagement with external contractors and consultants. -
Head Of External EngagementReplay Jan 2022 - Jul 2023Approached by Replay to provide expertise and guidance to establish a stealth enzyme engineering NewCo. ๐๐ข๐ฑ๐ฑ๐ฆ๐ฅ ๐ค๐ฐ๐ฎ๐ฎ๐ฆ๐ณ๐ค๐ช๐ข๐ญ ๐ญ๐ข๐ฏ๐ฅ๐ด๐ค๐ข๐ฑ๐ฆ ๐ต๐ฐ ๐ฆ๐ท๐ข๐ญ๐ถ๐ข๐ต๐ฆ ๐๐๐. - Performed analysis to outline market landscape, KOL identification and voice of customer. ๐๐ณ๐ฐ๐ฅ๐ถ๐ค๐ฆ๐ฅ ๐ต๐ข๐ณ๐จ๐ฆ๐ต ๐ฑ๐ณ๐ฐ๐ฅ๐ถ๐ค๐ต ๐ฑ๐ณ๐ฐ๐ง๐ช๐ญ๐ฆ๐ด. - Selected target enzymes (4) with scientific founders to (i) evaluate suitability to technology; (ii) map current industry benchmarks; (iii) establish product profiles to improve on current industry standard) and (iv) project/product delivery timelines. ๐๐ฐ๐ฏ๐ฅ๐ถ๐ช๐ต ๐ฃ๐ฆ๐ต๐ธ๐ฆ๐ฆ๐ฏ ๐ง๐ฐ๐ถ๐ฏ๐ฅ๐ฆ๐ณ๐ด ๐ข๐ฏ๐ฅ ๐ฃ๐ถ๐ด๐ช๐ฏ๐ฆ๐ด๐ด. - Engaged with technology transfer office from founder institution(s).
Sheena Mcgowan, Phd Education Details
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Microbiology -
Advancing Women In Senior Leadership -
Bsc (Biomed) (Hons) (Microbiology)
Frequently Asked Questions about Sheena Mcgowan, Phd
What company does Sheena Mcgowan, Phd work for?
Sheena Mcgowan, Phd works for The Termeer Foundation
What is Sheena Mcgowan, Phd's role at the current company?
Sheena Mcgowan, Phd's current role is Termeer Fellow.
What schools did Sheena Mcgowan, Phd attend?
Sheena Mcgowan, Phd attended Monash University, Melbourne Business School, Monash University.
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