Sheena Mcgowan, Phd

Sheena Mcgowan, Phd Email and Phone Number

Termeer Fellow @ The Termeer Foundation
San Diego, CA, US
Sheena Mcgowan, Phd's Location
San Diego, California, United States, United States
About Sheena Mcgowan, Phd

A versatile research and development leader with deep antimicrobial experience and broad drug development expertise. Passionate about building and nurturing, dynamic, high-performing teams to translate cutting-edge technologies into new products and therapeutics. I have over 20 yearsโ€™ experience in antimicrobial drug discovery, structure-based drug design, medicinal chemistry, structural biology, biochemistry from concept to lead molecule. I can build cross-functional teams and provide an essential link between scientists, collaborators and stakeholders to deliver products.I built a successful career as a tenured PI at Monash University (Australia) before choosing to transition to industry to pursue a strong desire to deliver real world solutions. I am widely published with >85 research papers and >130 structures generated in the protein databank. I have developed broad communications skills with experience in dilutive and non-dilutive funding applications, presentations to CEO, boards, research & development committees and at international scientific conferences. As a senior member of an Australian โ€˜Group of 8โ€™ University, I held multiple critical leadership roles that spanned academic departments, discovery centres and cross-faculty positions, leveraging an extensive skillset in strategy, operations and management.In my previous position, I established and led a global structure-based drug design program that delivered a new compound class to the global product developer. I raised $AUD12M, built and led a matrixed team (academic, VC and philanthropic stakeholders; chemistry, biology, DMPK, CRO scientists; product developers). The outcomes of this program were target ID, MoA characterization and target validation; hit discovery > hit-to-lead optimization; compound design and development; assay development and transition to high-throughput and computational screens; DMPK optimization; engagement with global product developer for transition to their pipeline.

Sheena Mcgowan, Phd's Current Company Details
The Termeer Foundation

The Termeer Foundation

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Termeer Fellow
San Diego, CA, US
Sheena Mcgowan, Phd Work Experience Details
  • The Termeer Foundation
    Termeer Fellow
    The Termeer Foundation
    San Diego, Ca, Us
  • Aurora Bioservices Llc
    Principal
    Aurora Bioservices Llc Sep 2024 - Present
    San Diego, California, United States
    Aurora Bioservices LLC provides contract R&D and consulting services for the Life Sciences, Biotechnology, and Pharmaceutical industries serving both small and large sized organizations. Particular expertise in structural biology, drug discovery, structure-based drug design, microbiology and biochemistry. Specific deliverables include:- Structural biology (crystallography, cryo-EM, computational) & structure-based drug design (ligand design, SAR).- Assay development and screening for hit discovery & hit-2-lead.- Anti-infective / anti-microbial resistance subject matter expertise.- Strategic development and planning for transition from early stage discovery.- Project plans and leadership - Outreach to KOLs, other scientists, and customers.- Funding and Investment (including dilutive and non-dilutive; pitch preparation).- Definition of Product and Product Development.
  • Stealth Biotech Start-Up
    Strategic Advisor
    Stealth Biotech Start-Up Jul 2024 - Present
    San Diego, California, United States
    Partnering with scientific founders to define early stages of growth and development.Advice and partnership in:- Market Analysis and Positioning- Strategic Planning for R&D Package- Funding and Investment (including dilutive and non-dilutive; pitch preparation)- Definition of Product and Product Development- Risk Management
  • Ptng Consulting
    Senior Consultant And Advisory Board Member
    Ptng Consulting 2020 - Present
    Providing specialized solutions in structural biology, protein engineering and design, and small molecule discovery and design.
  • Monash University
    Laboratory Head And Associate Professor (Tenured), Structural Microbiology
    Monash University Jan 2011 - Present
    ๐‡๐ž๐š๐, ๐’๐ญ๐ซ๐ฎ๐œ๐ญ๐ฎ๐ซ๐š๐ฅ ๐Œ๐ข๐œ๐ซ๐จ๐›๐ข๐จ๐ฅ๐จ๐ ๐ฒThe McGowan lab is a multidisciplinary team with expertise in structural biology, biochemistry, medicinal chemistry, drug design and computational biology. We study therapeutically important microbial proteins at the atomic level to understand their function.Using this data, we aim to discover lead molecules and guide drug development. ๐Œ๐š๐ฃ๐จ๐ซ ๐ฉ๐ซ๐จ๐ ๐ซ๐š๐ฆ๐ฌ๐˜ˆ๐˜ฎ๐˜ช๐˜ฏ๐˜ฐ๐˜ฑ๐˜ฆ๐˜ฑ๐˜ต๐˜ช๐˜ฅ๐˜ข๐˜ด๐˜ฆ ๐˜ช๐˜ฏ๐˜ฉ๐˜ช๐˜ฃ๐˜ช๐˜ต๐˜ฐ๐˜ณ๐˜ด ๐˜ข๐˜ด ๐˜ฏ๐˜ฆ๐˜ธ ๐˜ข๐˜ฏ๐˜ต๐˜ช๐˜ฎ๐˜ข๐˜ญ๐˜ข๐˜ณ๐˜ช๐˜ข๐˜ญ๐˜ด- Program outcomes include Target ID, MoA characterization and target validation; hit discovery > hit-to-lead; compound design and development; assay development + transition to HTS and computational screens; DMPK.- Top compound recognised as on-target by Medicines for Malaria Venture (MMV1557817).๐˜›๐˜ข๐˜ณ๐˜จ๐˜ฆ๐˜ต๐˜ช๐˜ฏ๐˜จ ๐˜ด๐˜ฑ๐˜ฐ๐˜ณ๐˜ถ๐˜ญ๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ ๐˜ต๐˜ฐ ๐˜ฑ๐˜ณ๐˜ฆ๐˜ท๐˜ฆ๐˜ฏ๐˜ต ๐˜Š. ๐˜ฅ๐˜ช๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ญ๐˜ฆ ๐˜ช๐˜ฏ๐˜ง๐˜ฆ๐˜ค๐˜ต๐˜ช๐˜ฐ๐˜ฏ ๐˜ณ๐˜ฆ๐˜ค๐˜ถ๐˜ณ๐˜ณ๐˜ฆ๐˜ฏ๐˜ค๐˜ฆ - Inhibition of key proteins in the sporulation pathway blocks spore formation and prevents reccurence in animal models. - Nature Micro, 2019; J Med Chem 2024๐˜‹๐˜ฆ๐˜ง๐˜ช๐˜ฏ๐˜ช๐˜ฏ๐˜จ ๐˜ฏ๐˜ฆ๐˜ธ ๐˜ข๐˜ฏ๐˜ต๐˜ช๐˜ฃ๐˜ข๐˜ค๐˜ต๐˜ฆ๐˜ณ๐˜ช๐˜ข๐˜ญ ๐˜ต๐˜ฐ๐˜น๐˜ช๐˜ฏ๐˜ดโ€ข Acinetobacter baumannii (Ab) uses protein toxins in inter-bacterial warfare to persist in healthcare environments.โ€ข We characterize the structure & function of new toxins and how Ab deploys them against other bacteria.๐˜‹๐˜ฆ๐˜ท๐˜ฆ๐˜ญ๐˜ฐ๐˜ฑ๐˜ช๐˜ฏ๐˜จ ๐˜ข ๐˜ฏ๐˜ฆ๐˜ธ ๐˜ฆ๐˜ฏ๐˜ป๐˜บ๐˜ฎ๐˜ฆ ๐˜ค๐˜ญ๐˜ข๐˜ด๐˜ด ๐˜ข๐˜ด ๐˜ค๐˜ญ๐˜ฆ๐˜ข๐˜ฏ๐˜ช๐˜ฏ๐˜จ ๐˜ข๐˜จ๐˜ฆ๐˜ฏ๐˜ต๐˜ด.โ€ข We exploit bacteriophage-encoded enzymes to disarm Klebsiella pneumoniae.โ€ข Our goal is to add stable, active enzymes to hospital-grade disinfectants.๐Ž๐ฎ๐ญ๐œ๐จ๐ฆ๐ž๐ฌ> 85 peer-reviewed publications (inc. Nature Micro, PNAS; eLife; EMBO J; mBio & J Med Chem).Funding ( ~ $15M) through competitive grants as well as private and public partners (inc MMV, Bill and Melinda Gates Foundation, Lgenia, HitGen, Gingko Bioworks)Supervised 20+ graduate students; formal University teaching (~1000 students/yr)
  • Monash University
    Deputy Head Of Department, Department Of Microbiology, Monash University
    Monash University Jun 2021 - Nov 2023
    Co-led vision and strategy for department (19 laboratories; ~ 220 staff / students; annual OpEx ~ $AUD15M) to ensure research excellence (publications in top tier journals, engagement with centres of research excellence, foundation member of other larger University and global initiatives). Undertook conflict resolution and performance development and management for senior staff. ๐‘๐ž๐œ๐ซ๐ฎ๐ข๐ญ๐ž๐ ๐š๐ง๐ ๐š๐๐ฏ๐š๐ง๐œ๐ž๐ ๐ก๐ข๐ ๐ก๐ฅ๐ฒ ๐ฌ๐ค๐ข๐ฅ๐ฅ๐ž๐ ๐ฌ๐œ๐ข๐ž๐ง๐ญ๐ข๐ฌ๐ญ๐ฌ. ๐˜š๐˜ฆ๐˜ค๐˜ถ๐˜ณ๐˜ฆ๐˜ฅ ๐˜ต๐˜ธ๐˜ฐ ๐˜ฏ๐˜ฆ๐˜ธ ๐˜ง๐˜ข๐˜ค๐˜ถ๐˜ญ๐˜ต๐˜บ ๐˜ฑ๐˜ฐ๐˜ด๐˜ช๐˜ต๐˜ช๐˜ฐ๐˜ฏ๐˜ด.- Wrote a successful business case based on data of teaching loads to secure additional OpEx. - Actively recruited outstanding, competitive talent, involved in appointment process and negotiation of support packages.๐˜”๐˜ฆ๐˜ฏ๐˜ต๐˜ฐ๐˜ณ๐˜ฆ๐˜ฅ ๐˜ข๐˜ฏ๐˜ฅ ๐˜ฆ๐˜ญ๐˜ฆ๐˜ท๐˜ข๐˜ต๐˜ฆ๐˜ฅ ๐˜ซ๐˜ถ๐˜ฏ๐˜ช๐˜ฐ๐˜ณ ๐˜ต๐˜ข๐˜ญ๐˜ฆ๐˜ฏ๐˜ต. - Initiated and ran an โ€œEmerging Leadersโ€ program to empower our brightest mid-career scientists to achieve their career goals. - The program had 4 candidates who each secured senior, independent positions within 18 months. ๐‚๐ก๐š๐ง๐ ๐ž ๐ฆ๐š๐ง๐š๐ ๐ž๐ฆ๐ž๐ง๐ญ. Laboratory and office space is a constant pain point for Universities! Tasked with ensuring each team had access to the necessary infrastructure (across multiple buildings) to ensure success. ๐˜Š๐˜ญ๐˜ฆ๐˜ข๐˜ณ ๐˜ค๐˜ฐ๐˜ฎ๐˜ฎ๐˜ถ๐˜ฏ๐˜ช๐˜ค๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ. - Undertook open consultation to establish open dialogue with laboratory PIs re their needs.๐˜›๐˜ณ๐˜ข๐˜ฏ๐˜ด๐˜ฑ๐˜ข๐˜ณ๐˜ฆ๐˜ฏ๐˜ค๐˜บ ๐˜ฐ๐˜ง ๐˜ฑ๐˜ณ๐˜ฐ๐˜ค๐˜ฆ๐˜ด๐˜ด.- Implemented a large scale move of equipment and some teams. Organised support for physical move(s).- Feedback from colleagues was positive and new space arrangements functional. ๐€๐ฌ๐ฌ๐ž๐ญ ๐ž๐ฏ๐š๐ฅ๐ฎ๐š๐ญ๐ข๐จ๐ง ๐š๐ง๐ ๐š๐ฎ๐๐ข๐ญ ๐ญ๐จ ๐ž๐ง๐ฌ๐ฎ๐ซ๐ž ๐š๐œ๐œ๐ฎ๐ซ๐š๐ญ๐ž ๐‚๐š๐ฉ๐„๐ฑ. After commencing my role, I realised there was no asset register and no forecast for CapEx. ๐˜Š๐˜ฐ๐˜ฎ๐˜ฑ๐˜ญ๐˜ฆ๐˜ต๐˜ฆ๐˜ฅ ๐˜ข๐˜ด๐˜ด๐˜ฆ๐˜ต ๐˜ข๐˜ถ๐˜ฅ๐˜ช๐˜ต.- Provided data for accurate CapEx forecast. Prevent downtime due to equipment failure or maintenance.
  • Monash University
    Director Industry Engagement, Monash Biomedicine Discovery Institute
    Monash University Nov 2019 - Aug 2023
    Melbourne, Victoria, Australia
    The Monash Biomedicine Discovery Institute (BDI) incorporates over 120 research teams committed to global health priorities. With over 700 staff and students and an annual research income of over $AUD65M, the BDI is one of the largest and highest quality research institutes in the southern hemisphere. The BDI Industry Engagement (IE) team supported project and alliance management; education and outreach; engagement and networking.Activities include- Liaison between researchers and technology transfer office.- Education and outreach for early career researchers.- Events to raise engagement between researchers and industry stakeholders.- Networking events.- Recruitment and career advice.
  • Replay
    Senior Director
    Replay Aug 2023 - Jul 2024
    San Diego, California, United States
    Led product & project management for Genome Writing, one of three core pillars of the company, to define vision, killer application, specifications, and act as voice of customer for Replayโ€™s genome writing service.๐˜‹๐˜ฆ๐˜ง๐˜ช๐˜ฏ๐˜ฆ๐˜ฅ ๐˜ข๐˜ฏ๐˜ฅ ๐˜ฆ๐˜ท๐˜ฐ๐˜ญ๐˜ท๐˜ฆ๐˜ฅ ๐˜ญ๐˜ฐ๐˜ฏ๐˜จ-๐˜ต๐˜ฆ๐˜ณ๐˜ฎ ๐˜ฑ๐˜ณ๐˜ฐ๐˜ฅ๐˜ถ๐˜ค๐˜ต ๐˜ท๐˜ช๐˜ด๐˜ช๐˜ฐ๐˜ฏ.- Identified areas for innovation and differentiation.- Defined OKRs for product technology.๐˜ž๐˜ณ๐˜ฐ๐˜ต๐˜ฆ ๐˜ฏ๐˜ฐ๐˜ฏ-๐˜ฅ๐˜ช๐˜ญ๐˜ถ๐˜ต๐˜ช๐˜ท๐˜ฆ ๐˜ง๐˜ถ๐˜ฏ๐˜ฅ๐˜ช๐˜ฏ๐˜จ ๐˜ข๐˜ฑ๐˜ฑ๐˜ญ๐˜ช๐˜ค๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ๐˜ด (๐˜ˆ๐˜™๐˜—๐˜ˆ-๐˜; ๐˜š๐˜‰๐˜๐˜™; ๐˜Š๐˜๐˜™๐˜”). - Successful ARPA-H expression of interest; invitation to full proposal ($27M).๐˜Š๐˜ณ๐˜ฐ๐˜ด๐˜ด-๐˜ง๐˜ถ๐˜ฏ๐˜ค๐˜ต๐˜ช๐˜ฐ๐˜ฏ๐˜ข๐˜ญ ๐˜ญ๐˜ฆ๐˜ข๐˜ฅ๐˜ฆ๐˜ณ๐˜ด๐˜ฉ๐˜ช๐˜ฑ. - Transitioned 7 scientists from operating as an academic group to matrixed team. ๐˜Œ๐˜ญ๐˜ฆ๐˜ท๐˜ข๐˜ต๐˜ฆ๐˜ฅ ๐˜ฑ๐˜ณ๐˜ฐ๐˜ฎ๐˜ช๐˜ด๐˜ช๐˜ฏ๐˜จ ๐˜ซ๐˜ถ๐˜ฏ๐˜ช๐˜ฐ๐˜ณ ๐˜ต๐˜ข๐˜ญ๐˜ฆ๐˜ฏ๐˜ต. - Promoted senior scientist to first technical leadership role.๐˜–๐˜ณ๐˜จ๐˜ข๐˜ฏ๐˜ช๐˜ป๐˜ฆ๐˜ฅ ๐˜ฐ๐˜ฑ๐˜ฆ๐˜ณ๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ๐˜ข๐˜ญ ๐˜ด๐˜ค๐˜ข๐˜ง๐˜ง๐˜ฐ๐˜ญ๐˜ฅ๐˜ด ๐˜ง๐˜ฐ๐˜ณ ๐˜ฆ๐˜ง๐˜ง๐˜ช๐˜ค๐˜ช๐˜ฆ๐˜ฏ๐˜ค๐˜บ.- Implemented team productivity tools for improved communication and project management.- Coordinated change in data management tools for secure data storage.- Produced policies to steward engagement with external contractors and consultants.
  • Replay
    Head Of External Engagement
    Replay Jan 2022 - Jul 2023
    Approached by Replay to provide expertise and guidance to establish a stealth enzyme engineering NewCo. ๐˜”๐˜ข๐˜ฑ๐˜ฑ๐˜ฆ๐˜ฅ ๐˜ค๐˜ฐ๐˜ฎ๐˜ฎ๐˜ฆ๐˜ณ๐˜ค๐˜ช๐˜ข๐˜ญ ๐˜ญ๐˜ข๐˜ฏ๐˜ฅ๐˜ด๐˜ค๐˜ข๐˜ฑ๐˜ฆ ๐˜ต๐˜ฐ ๐˜ฆ๐˜ท๐˜ข๐˜ญ๐˜ถ๐˜ข๐˜ต๐˜ฆ ๐˜™๐˜–๐˜. - Performed analysis to outline market landscape, KOL identification and voice of customer. ๐˜—๐˜ณ๐˜ฐ๐˜ฅ๐˜ถ๐˜ค๐˜ฆ๐˜ฅ ๐˜ต๐˜ข๐˜ณ๐˜จ๐˜ฆ๐˜ต ๐˜ฑ๐˜ณ๐˜ฐ๐˜ฅ๐˜ถ๐˜ค๐˜ต ๐˜ฑ๐˜ณ๐˜ฐ๐˜ง๐˜ช๐˜ญ๐˜ฆ๐˜ด. - Selected target enzymes (4) with scientific founders to (i) evaluate suitability to technology; (ii) map current industry benchmarks; (iii) establish product profiles to improve on current industry standard) and (iv) project/product delivery timelines. ๐˜Š๐˜ฐ๐˜ฏ๐˜ฅ๐˜ถ๐˜ช๐˜ต ๐˜ฃ๐˜ฆ๐˜ต๐˜ธ๐˜ฆ๐˜ฆ๐˜ฏ ๐˜ง๐˜ฐ๐˜ถ๐˜ฏ๐˜ฅ๐˜ฆ๐˜ณ๐˜ด ๐˜ข๐˜ฏ๐˜ฅ ๐˜ฃ๐˜ถ๐˜ด๐˜ช๐˜ฏ๐˜ฆ๐˜ด๐˜ด. - Engaged with technology transfer office from founder institution(s).

Sheena Mcgowan, Phd Education Details

Frequently Asked Questions about Sheena Mcgowan, Phd

What company does Sheena Mcgowan, Phd work for?

Sheena Mcgowan, Phd works for The Termeer Foundation

What is Sheena Mcgowan, Phd's role at the current company?

Sheena Mcgowan, Phd's current role is Termeer Fellow.

What schools did Sheena Mcgowan, Phd attend?

Sheena Mcgowan, Phd attended Monash University, Melbourne Business School, Monash University.

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