Sheldon Rowan
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Sheldon Rowan Email & Phone Number

Location: Boston, Massachusetts, United States 9 work roles 2 schools
1 work email found @tufts.edu LinkedIn matched
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Role
Scientist II
Location
Boston, Massachusetts, United States
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Sheldon Rowan is listed as Scientist II at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, a with 80 employees, based in Boston, Massachusetts, United States. AeroLeads shows a work email signal at tufts.edu and a matched LinkedIn profile for Sheldon Rowan.

Sheldon Rowan previously worked as Chair, Division of Biochemical and Molecular Nutrition at The Gerald J. And Dorothy R. Friedman School Of Nutrition Science And Policy At and Chair, Division of Biochemical and Molecular Nutrition at The Gerald J. And Dorothy R. Friedman School Of Nutrition Science And Policy At Tufts University. Sheldon Rowan holds Ph. D., Genetics from Harvard University.

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Profile bio

About Sheldon Rowan

I am interested in the intersection of nutrition, aging, and age-related diseases of the visual system, primarily age-related macular degeneration and cataracts. I use model organisms and genetic approaches to understand disease pathobiology and pathetiology with goal of revealing new therapeutic possibilities. My current studies are focused on understanding the role of the gut microbiome in retinal diseases, and its relationship to carbohydrate quality and glycemia.Specialties: Genetics, Mouse models, Aging research, Ophthalmology, Immunohistochemistry, Pathology, Metabolism, Diet, Microbiome, Metabolomics, Biomarkers

Listed skills include Genetics, Biochemistry, Microscopy, Molecular Biology, and 40 others.

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Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Jean Mayer Usda Human Nutrition Research Center On Aging At Tufts University
Scientist II
Boston, MA, US
Website
Employees
80
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9 roles

Sheldon Rowan work experience

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Scientist Ii

Greater Boston Area

My research focuses on two diseases of the eye that are related to aging: age-related macular degeneration (AMD) and cataract formation. My research on AMD is characterizing the roles of dietary glycemic index and genetic factors in development of AMD and therapeutic intervention via dietary change or pharmaceuticals. My research on cataracts is evaluating the function of the ubiquitin proteolysis pathway in development and homeostasis of the lens. Combined, my research will impact over 90% of a continually aging population and offer new interventions in vision-threatening diseases.

Research Fellow

My work in the Maas lab centered on two essential pathways required for lens formation. The first is Notch signaling, where I demonstrated essential roles for Notch signaling during lens induction, differentiation, and proliferation. I also identified Notch target genes involved in these processes, several of which may be deregulated during abnormal tissue growth and morphogenesis, such as that during tumor development. The second is elucidating novel upstream regulatory factors involved in Pax6 initiation during lens induction. I identified Prep1 as such an essential upstream factor and used a systems biology and genetic interdisciplinary approach to characterize a new regulatory mechanism whereby Prep1 binds to two lower-affinity binding sites in Pax6 regulatory sequences, which together synergistically activate correct levels of Pax6 expression at the correct time during lens development.

Mar 2004 - Jan 2012

Postdoctoral Fellow

My research in the Cepko lab related to understanding different features of retinal development. With a particular interest in the homeodomain transcription factor Chx10, my work described the upstream transcriptional regulation of Chx10, the function of Chx10 in bipolar cell differentiation, and early functions of Chx10 in maintaining retinal versus retinal pigment cell identity. As a genetic tool, I created a transgenic mouse line that expresses Cre recombinase, green fluorescent protein, and alkaline phosphatase under control of Chx10 regulatory elements. This mouse has been widely used to perform retina-specific gene knockouts and to perform fate mapping experiments in the mouse retina.

Sep 2003 - Mar 2004
2 education records

Sheldon Rowan education

FAQ

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What company does Sheldon Rowan work for?

Sheldon Rowan works for Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

What is Sheldon Rowan's role at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University?

Sheldon Rowan is listed as Scientist II at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

What is Sheldon Rowan's email address?

AeroLeads has found 1 work email signal at @tufts.edu for Sheldon Rowan at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

Where is Sheldon Rowan based?

Sheldon Rowan is based in Boston, Massachusetts, United States while working with Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University.

What companies has Sheldon Rowan worked for?

Sheldon Rowan has worked for Jean Mayer Usda Human Nutrition Research Center On Aging At Tufts University, The Gerald J. And Dorothy R. Friedman School Of Nutrition Science And Policy At, The Gerald J. And Dorothy R. Friedman School Of Nutrition Science And Policy At Tufts University, Tufts University School Of Medicine, and Brigham And Women'S Hospital.

How can I contact Sheldon Rowan?

You can use AeroLeads to view verified contact signals for Sheldon Rowan at Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, including work email, phone, and LinkedIn data when available.

What schools did Sheldon Rowan attend?

Sheldon Rowan holds Ph. D., Genetics from Harvard University.

What skills is Sheldon Rowan known for?

Sheldon Rowan is listed with skills including Genetics, Biochemistry, Microscopy, Molecular Biology, Immunohistochemistry, Histopathology, Animal Models, and Cell Biology.

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