Farhad Shiri, Ph.D. Email & Phone Number

St. Louis, Mo, Us

Greater St. Louis

Marcy-L'Étoile, Auvergne-Rhône-Alpes, Fr

🔹 Leading Manufacturing Innovation: I led the adoption of the injection molding technique for the fabrication of thermoplastic-based micro/nanofluidic devices. Achieving structures as small as 20 nm, this technique has been a game-changer in precision manufacturing.🔹 Expertise in Cleanroom Processes: My responsibilities extend to overseeing key equipment, including hot embossing and injection molding machines. I also provide specialized training in complex cleanroom processes, such as thin film deposition, photolithography, and nano imprint lithography, emphasizing precision and safety.🔹 Collaborative Research Projects: I've had the opportunity to collaborate with prestigious academic institutions like LSU, UNC, and Wake Forest University, as well as industry partners such as CytoRecovery, Inc. These collaborations have been integral in advancing research in areas including single molecule identification, DNA/RNA sequencing, and cell sorting.🔹 Team-Based Development Initiatives: I work closely with talented teams on innovative projects. A notable achievement was collaborating on the development of an exonuclease time-of-flight (X-ToF) device for single-molecule DNA/RNA sequencing, and an integrated system for detecting liquid biopsy markers. These projects not only highlight our technical expertise but also our commitment to advancing medical research and diagnostics.

Salt Lake City, Utah, Us

Developing a high-throughput ion transport assay system• Charted the design and fabrication of nanofiber polyvinylidene fluoride (PVDF) membranes through utilization of electrospinning technique.• Effectively utilized the sputtering technique to deposit nanolayer gold on the membrane.• Employed scanning electron microscopy to characterize the membranes.• Handled the preparation of the lipid bilayer membrane by centrifugation of liposomes.• Oversaw the development of an experimental procedure for testing the diffusion through the lipid bilayer membrane.• Provided in-depth training and supervision to one student.

Developing a mimic of a DNA biosensor in order to determine an appropriate sensing mechanism, • Conducted the fabrication of an electric-based biosensor for DNAs.• Utilized electroimpedance spectroscopy (EIS) and chronoamperometry to electrically characterize and model the device.• Piloted the development of an experimental procedure for electrical characterization of DNAs using Möbiuζ.• Drove the creation and development of an experimental procedure for detection of DNAs using fluorescence-based nucleic acid detection technique.• Played a key role by developing a COMSOL model for simulation of hybridization of DNAs under the effect of the electric field in order to determine appropriate sensing conditions.• Conducted the validation of the fabricated DNA biosensor.

Inertial Focusing Separation Techniques for Exosomes and Oncosomes, • Administered the design, building, and testing of microfluidic inertial focusing device (spiral channel) for separation of exosomes and oncosomes.• Performed the separation of exosomes and oncosomes using the spiral channel.

Electrical and Flow Separation Techniques for exosomes and oncosomes, • Oversaw the fabrication and testing of the microfluidic electrical and flow-based biological nanoparticle separation systems.• Explored and investigated continuous separation of exosomes and oncosomes using electric flow Split-flow lateral transport thin separation cell (El-Fl-SPLITT)• Employed dynamic light scattering to characterize exosomes and oncosomes.• Dispensed mentoring, training, and supervision for two students.

Electrical and Flow Separation Techniques for Virus-like particles, • Administered the separation of different types of virus-like particles (VLPs) with different surface conjugated custom peptides based on their electrophoretic mobility and size and also separated the monomer VLPs from the aggregated ones using electric field-flow fractionation (ElFFF) and asymmetrical flow field-flow fractionation (AF4) techniques.• Oversaw the development of detection management systems using custom software and detection instrumentation.• Conducted the characterization of VLPs using multi angle light scattering (MALS), mobius, dynamic light scattering (DLS), and Transmission Electron Microscopy (TEM).• Led the development and implementation of a Python programming code in order to collect data from a multimeter device.• Provided training to two students and oversaw their operations.

Modeling of Air Flow in the Respiratory System of Crocodile and Iguana, • Spearheaded the design and development of an experimental procedure for direct measurement of air flow in the respiratory system of crocodile and iguana.• Effectively utilized OpenFoam, a C++ toolbox, to simulate the airflow in the respiratory system of crocodile and iguana.

• Oversaw all operations of the design and installation team for the air conditioning system in the Barzagan Customs Office.• Charted the design of the pipeline system of Maku Hospital and Milad and Laleh hotels.• Operated in a pivotal capacity by providing excellent servicing and maintenance of pumps, compressors, and fans.

Modeling of Cardiovascular System• Performed the simulation of the cardiovascular system by 1D model coupled with the lumped model using finite element method and integrated it with the cuff pressure model (MATLAB).• Conducted the modeling of the photoplethysmography signal for quantitative analysis of endothelial cells during reactive hyperemia based on the model of the cardiovascular system.• Administered in-depth statistical analysis into photoplethysmography signals of patients using R.

Exergy and Thermoeconomic Analysis• Played a vital role by providing the first Exergy and thermoeconomic analysis of ethane and methane extraction unit and butane and propane production unit in a natural gas refinery located in the South Persian gas field.

Doctor Of Philosophy (Phd), Microfluidics

Doctor Of Philosophy (Ph.D.), Computational Biology

Master Of Science (Ms), Biofluid

Bachelor Of Science (Bs), Mechanical Engineering