Shivam Sharma Email & Phone Number

Atlanta, Ga, Us

Atlanta, Georgia, United States

I'm working in Prof. I. King Jordan's lab where we study the impact of genetic ancestry on complex health phenotypes in genetically diverse populations. Brief description of my recently completed projects:Genetic ancestry inference in the All of Us research program• Lead developer of the featured demonstration workspace “Genetic Ancestry Inference” hosting reproducible jupyter notebooks in the cloud-based researcher workbench• Inferred & visualized continuous genetic ancestry for over 300k participants using unsupervised and supervised clustering algorithmsBiobank scale analysis• Compiled >100 million electronic health records from >250k individuals into case-control cohort to characterize the landscape of health disparity in the US• Performed phasing & annotation of sequencing data followed by implementation of a fast HAIL pipeline to characterize compound heterozygosity in the UK Biobank WES (>100k) & clinical WGS data (>3k)• Established that self-identified race & ethnicity carries clinically actionable pharmacogenomic information in the UK & US using a suite of machine learning models (random forests, SVM)• Developed a genetic data harmonization pipeline which performs quality control, harmonizes, and merges genotyping & sequencing data from >15 clinical labs

Minneapolis, Minnesota, United States

• Identified 9 novel & refined existing ancestral group definitions in the HLA haplotype data from themarrow donor registry containing >1 million individuals• Aimed at improving marrow donor matching accuracy for individuals belonging to minority groups such as Afro-Hispanics & Ashkenazi Jews

Bethesda, Maryland, United States

I worked at the Genomics Research for Health Equity lab at NIMHD (NIH) through ASRT, Inc. Summary of my work:• Identified health disparities between ethnic groups in the UK and investigated the role of genetic ancestry and socio-economic deprivation in disparate biomarker levels between ethnic groups• Performed association testing between ancestral haplotypes and disparate biomarkers among ethnic groups• Worked on merging, harmonization, and continental & local ancestry inference for several public and clinical WGG & WGS datasets

Atlanta, Georgia, United States

• Worked on finding the effects of aberrant alternative splicing and mutations existing on messenger-RNAs that can change the regulatory control mechanism of gene expression carried out by micro-RNAs in cancer.

Atlanta, Georgia, United States

• Served as a Graduate Teaching Assistant for a core bioinformatics graduate level class "Programming for Bioinformatics" (BIOL7200).• Responsible for guiding students during the class, designing and grading assignments, weekly office hours and technology support.

Boston, Massachusetts, United States

• Performed Variant Calling to ensure the integrity of therapeutic protein producing cell lines sequenced through NGS Amplicon sequencing and RNA-Seq.• Implemented a “One-Key” Variant Calling Pipeline to confidently determine SNVs, InDels, and Fusion Proteins from the wet lab generated NGS Amplicon & RNA-Seq data.

New Delhi Area, India

• Integrated overlapping data from popular large-scale public databases to create a one-click link between micro-RNAs, Target Genes, messenger-RNAs, and Biological Pathways.• Created miRDex [www.mirdex.org], a Web Application for micro-RNA - gene; pathway - gene - micro-RNA; and Gene - Pathway; interaction network visualization with additional user-end file support for Cytoscape (Software).• Used Deep Neural Network based Auto-Encoders and Self-Organizing maps for clustering of micro-RNA - Gene - Pathway datasets.

New Delhi Area, India

• Developed and deployed university-wide large-scale official web portal for Training & Placement Cell to facilitate the interaction between recruiting companies, students and the university.• A self-initiative project which had features such as: email, text message, and web-based notification system; resume management; news feed; online application to jobs.• Trained and mentored a team of juniors and sophomores in web-development as part of T&Pclub.

Doctor Of Philosophy - Phd, Bioinformatics

Master'S Degree, Bioinformatics

Bachelor Of Technology - Btech, Information Technology, First Class With Distinction

High School Diploma