Shon Pulley, Ph.D. Email and Phone Number
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I am a Pharmaceutical R&D leader with a passion for second order thinking in the design and execution of strategies to address the what? the why? and the how? in the advancement of innovation meeting customer needs. My team leadership principles are grounded in teamwork, trust and humility creating an engaged team environment. I have a diverse background in veterinary and human health leading scientific research and operational management. I excel at connecting the dots between science, capabilities, resources and operational excellence to meet corporate business objectives. I am a problem solver with high learning agility able to quickly identify and resolve issues, acquire and apply new knowledge.Experienced (+20 years) in drug discovery (medicinal chemistry) and early development including setting strategy, budget and resources for multi-functional and cultural teams (+50 FTEs direct/in-line) in chemistry, biology, drug disposition/safety, process/analytical technologies and laboratory management.Experience in building and managing external investigator collaborations, including technical and alliance management. Includes relationship building with industrial partners in collaboration with internal subject matter experts, and BD&L. Led global strategic initiatives resulting in improved efficiency and effectiveness across the enterprise.Diverse therapeutic/species experience (e.g., parasitology, pain, dermatology, metabolic, oncology, neuroscience etc.) involving formulating hypotheses, designing, and executing strategy resulting in 15 issued patents, author/co-author on 21 papers and 1 book chapter.Specialties: Global Leadership | Leading Change and Transformation | Strategy and Business Plan Development/Execution | Lab Management | Collaborations with External Partners | Supervising/Developing People | Medicinal chemistry | Drug Discovery | Lead generation I Structure Based Drug Design |CMC| CRO/CDMO externalization | Capital Improvements |
Rome Therapeutics
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Vice President, Medicinal ChemistryRome Therapeutics Jun 2023 - PresentBoston, Massachusetts, Us
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Senior Director Medicinal ChemistryRome Therapeutics Jul 2022 - Jun 2023Boston, Massachusetts, Us
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Independent ConsultantSolterra Consulting Llc Mar 2021 - Present
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Senior Director Research TechnologiesElanco Mar 2019 - Feb 2021Greenfield, In, UsLed a multi-disciplinary team accountable for process and analytical development, drug disposition/safety, pre-formulation and computational sciences. Enhanced the organizational approach to early research, managing upstream and downstream stakeholders to ensure continuity into development.• Optimized resource allocation to deliver milestones for ~30 portfolio projects on time and on budget.• Leveraged broad drug development experience to implement a knowledge management platform for electronic notebook (eLN), molecule registration, sample management and supporting discovery research data workflow (included establishing processes, training and quality management) which serves as the foundation for information tracking from inception to approval.• Drove the organization to focus on projects with higher probability of technical success by creating and implementing a technical asset assessment process that provides consistent risk/gaps analysis, leading teams to focus on critical tasks.• Identified laboratory infrastructure deficiencies, enabled a strategy to implement solutions, secured business plan funding, executed capital improvement to support strategic research functions (biopharma, microbiome, vaccine). -
Director Elanco Research LaboratoriesElanco Mar 2017 - Mar 2019Greenfield, In, UsAccountable for the Elanco Research Labs (ERL) and Lab Operations (> 50 FTE).• Created and implemented the ERL strategy uniting chemistry/biology, virology, bacteriology, drug disposition/safety, computational, enzyme research functions and laboratory operations in US and EU supporting research portfolio.• Managed organizational change by building discovery biology, and technologies functions to maximize efficiency of ERL teams. Coached and mentored junior scientists. Recruited and hired (9) diverse staff in ADME, assay development, formulation.• Co-Led and established a biopharma research strategy at Elanco (hired FTEs and secured funding).• Initiated external research collaboration with a Japanese Ag. Chem. using an internal asset.
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Director Companion Animal ResearchElanco Apr 2016 - Feb 2017Greenfield, In, UsResponsible for companion animal therapeutic area research. Aligned key cross functional stake holders to ensure alignment of research portfolio with customer needs.• Created companion animal research strategy and defined expected deliverable metrics with Sr. Management.• Defined targets, models, budget and resources along with key external partners to enable strategy supporting portfolio progression.• Led team of 4 scientist responsible for executing proof of concept studies for diabetes, OA pain, dermatology. • Accountable for and maintained external collaboration to complement internal parasitology research capabilities.
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Principal Research ScientistElanco Oct 2013 - Apr 2016Greenfield, In, UsChemistry scientific lead for R&D team for companion animal parasiticides and therapeutics.• Responsible for leading an integrated chemistry, biology and ADME team with an external collaborator for the discovery of a novel treatment for canine heartworm.• Initiated collaborations with Japanese Ag Chem companies supporting parasiticide portfolio strategy.• Provided strategic and scientific leadership in collaboration with external partner to identify an NME for treatment of GI nematodes in cattle, resulting in a development candidate.• Provided chemistry leadership and strategic contributions to the companion animal Global Parasiticide Strategy for the selection and evaluation of internal and external compounds.• Developed a technical solution critical to the successful launch of Cheristin® in the US market.
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Senior Research ScientistElanco Oct 2011 - Oct 2013Greenfield, In, UsCompanion and Food Animal Research and Development
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Senior Research ChemistD&M Continuous Solutions, Llc Aug 2010 - Oct 2011Technology design and development for continuous flow chemistry applied to API process development• Developed a continuous flow Ir-catalyzed homogenous reductive amination
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Research AdvisorEli Lilly And Company Nov 2006 - Jun 2010Indianapolis, Indiana, UsProject leader with biology colleagues and external collaborators in the progression of inhibitors of G-protein coupled receptors in oncology. Teams included internal and external collaborators from chemistry, biology, and drug dispositionTeam leader in collaboration with an external partner, charged with identifying a compound for target validation of a G-protein coupled receptor in the inhibition of painContributed to a strategic plan for compound acquisition and capital equipment purchase to support ion channel initiatives in collaboration with colleagues from biology and therapeutic area representativesKey member of core team responsible for delivering and training end-users on a global solution for lab supply and reagent management. Resulting in cost savings and increased safety complianceMentored and collaborated with external CRO chemists to support lab projects -
Principal Research ScientistEli Lilly And Company Aug 2003 - 2006Indianapolis, Indiana, UsScientific team leader for lead generation and optimization efforts targeting chemokine G-protein coupled receptors for oncology and inflammation. Partnered with biology, drug disposition, toxicology and governance colleagues to reach data driven and strategic decisions for these efforts. Co-sponsor for a Six Sigma project that designed and implemented a process for all internal drug discovery teams to request and receive standards for target validation using contract research resources.Co-recipient of 2005 Lilly Research Labs Presidents Award for a transformational process evaluating actives from a screen and identifying scaffolds with high probability of progressing to lead optimizationContributed to a structure based drug design effort for the serine protease DPP-IV for diabetes. Co-inventor on 3 patent applications related to this workSupervision of 1-2 M.S. level scientists and 2 external contract research chemists
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Research And Development ScientistPharmacia & Upjohn 2000 - 2003Contributing team member of a large cross-functional and external partner collaboration charged with the identification of inhibitors of beta-secretase for the treatment of Alzheimer'sDesigned and implemented novel SAR for inhibitors of beta-secretase using structure based drug designManaged CRO chemistry resources for teamDirect supervision of 2 M.S. level scientists -
Assistant ProfessorUniversity Of Missouri 1995 - 2000Columbia, Mo, UsAssistant Professor of Organic ChemistrySynthesis of C-arylglycosides, biaryl ethers, and phenyl glycines using chromium carbene complexesSynthesis of (S,S)-IsodityrosineUndergraduate and Graduate teaching
Shon Pulley, Ph.D. Skills
Shon Pulley, Ph.D. Education Details
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Colorado State UniversityChemistry -
Indiana University BloomingtonBusiness Of Life Sciences
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Stanford UniversityOrganic Chemistry
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Utah State UniversityChemistry
Frequently Asked Questions about Shon Pulley, Ph.D.
What company does Shon Pulley, Ph.D. work for?
Shon Pulley, Ph.D. works for Rome Therapeutics
What is Shon Pulley, Ph.D.'s role at the current company?
Shon Pulley, Ph.D.'s current role is Principal and Owner at SolTerra Consulting LLC | Pharmaceutical R&D | Drug Discovery | External Collaborations.
What is Shon Pulley, Ph.D.'s email address?
Shon Pulley, Ph.D.'s email address is pu****@****nco.com
What schools did Shon Pulley, Ph.D. attend?
Shon Pulley, Ph.D. attended Colorado State University, Indiana University Bloomington, Stanford University, Utah State University.
What skills is Shon Pulley, Ph.D. known for?
Shon Pulley, Ph.D. has skills like Drug Discovery, Medicinal Chemistry, Pharmaceutical Industry, Organic Chemistry, Chemistry, Drug Design, Drug Development, Synthetic Organic Chemistry, Cro, Organic Synthesis, Chromatography, Glp.
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