- Design and develop metabolite and electrolyte assays/sensors for in vitro diagnostic point-of-care applications from pre-development through product release.- Develop and apply rational design techniques to improve assay/sensor formulations for enhanced robustness, quality and performance.- Conduct process development studies for various R&D project phases, and lead troubleshooting efforts to determine root causes.- Work in a cross-functional and interdisciplinary team effort with reagent scientists, engineers and manufacturing personnel.- Solid experience in system-oriented fluidics design and development for next generation medical devices with application of in vitro diagnostics, critical care and laboratory tests.

- Designed cell-based assays to study effects of oxidative stress on intracellular zinc in E.coli via fluorescent (FRET) sensors based on carbonic anhydrase - red protein fusions.- Designed, synthesized and implemented Co(III)-ligand complexes as novel ionophore (ion recognition components) with largely improved nitrite/nitrate binding affinity for nitrite/nitrate assay and potentiometric/optical sensor development.- Designed and developed nitrite/nitrate assay and sensor via employing newly synthesized ionophore with greatly enhanced sensitivity and selectivity for potential applications in clinical and environmental analysis.- Applied optimized assay formulation for measurement of nitric oxide liberated from in vivo device coating material with proven assay robustness and comparable performance to the gold standard chemiluminescent method.

- Invented a unique alcohol-free sol-gel approach for biosensor fabrication technique that has been successfully employed to design an electrochemistry based enzymatic biosensor with excellent sensitivity and long term stability.- Developed an enzyme-free glucose biosensor using gold nanoparticle-integrated nanotube array electrode fabricated in the porous anodic alumina (PAA) template by electroless plating.- Designed and fabricated a simple dual-microelectrode system to selectively detect hydrogen peroxide by creating an interference-free region in the diffusion layer of one electrode.