After GSK acquisition of Novartis Vaccines unit, I joined in GSK Vaccines unit with the same previous position.Team manager of a group of 7 people in the Analytical Development department. In this role I have the responsibility and management of several complex analytical platforms, in particular: Multi Angle Light Scattering (SEC-MALS) coupled with HPLC or UPLC, Evaporative Light Scattering-UPLC, Fluorescence and Circular Dichroism spectroscopies, Differential Scanning Calorimetry… Show more After GSK acquisition of Novartis Vaccines unit, I joined in GSK Vaccines unit with the same previous position.Team manager of a group of 7 people in the Analytical Development department. In this role I have the responsibility and management of several complex analytical platforms, in particular: Multi Angle Light Scattering (SEC-MALS) coupled with HPLC or UPLC, Evaporative Light Scattering-UPLC, Fluorescence and Circular Dichroism spectroscopies, Differential Scanning Calorimetry (DSC), Capillary Electrophoresis, SDS-PAGE Electrophoresis and Western Blot technics, Dynamic Light Scattering (DLS).Major Accountabilities and Expertise:- Validation and transfer of analytical methods to commercial manufacturing operations (QC Lab) following the ICH, FDA and WHO guidance - Implementation of Quality by Design approach for analytical methods and vaccines development - Introduce novel technologies/methods for analytical development activities- People management- Laboratory Management- Laboratory Instrument System Owner: management of instrument qualification and maintenance according to GMP requirements- Physicochemical studies for comparability purposes or reference standard-characterization- Characterization of glycol-conjugates, proteins and Outer Membrane Vesicles- Use of the Sentry Quality Platform for Change Request and Deviation report management. Show less

Team manager of a group of 7 people in the Analytical Development department. In this role I have the responsibility and management of several complex analytical platforms, in particular: Multi Angle Light Scattering (SEC-MALS) coupled with HPLC or UPLC, Evaporative Light Scattering-UPLC, Fluorescence and Circular Dichroism spectroscopies, Differential Scanning Calorimetry (DSC), Capillary Electrophoresis, SDS-PAGE Electrophoresis and Western Blot technics, Dynamic Light Scattering… Show more Team manager of a group of 7 people in the Analytical Development department. In this role I have the responsibility and management of several complex analytical platforms, in particular: Multi Angle Light Scattering (SEC-MALS) coupled with HPLC or UPLC, Evaporative Light Scattering-UPLC, Fluorescence and Circular Dichroism spectroscopies, Differential Scanning Calorimetry (DSC), Capillary Electrophoresis, SDS-PAGE Electrophoresis and Western Blot technics, Dynamic Light Scattering (DLS).Major Accountabilities and Expertise:- Validation and transfer of analytical methods to commercial manufacturing operations (QC Lab) following the ICH, FDA and WHO guidance - Implementation of Quality by Design approach for analytical methods and vaccines development - Introduce novel technologies/methods for analytical development activities- People management- Laboratory Management- Laboratory Instrument System Owner: management of instrument qualification and maintenance according to GMP requirements- Physicochemical studies for comparability purposes or reference standard-characterization- Characterization of glycol-conjugates, proteins and Outer Membrane Vesicles- Use Sentry Quality Platform for Change Request and Deviation report management. Show less

Deep experience and knowledge developed in all the principal matters regarding the Analytical Development, in particular:Analytical methods development, validation and transfer to Quality Control Laboratory.Antigen characterization (protein, Outer Membrane Vesicle, polysaccharides and glycol-conjugates) by use of several chemical-physical technics: Dynamic Light Scattering and Zeta Potential, reverse phase and Size Exclusion chromatography (also coupled with SEC-MALS), UV-Vis… Show more Deep experience and knowledge developed in all the principal matters regarding the Analytical Development, in particular:Analytical methods development, validation and transfer to Quality Control Laboratory.Antigen characterization (protein, Outer Membrane Vesicle, polysaccharides and glycol-conjugates) by use of several chemical-physical technics: Dynamic Light Scattering and Zeta Potential, reverse phase and Size Exclusion chromatography (also coupled with SEC-MALS), UV-Vis and Fluorescence spectroscopies.Knowledge in the visible and sub-visible particles analyses and the main technics used for their detection, such as: Laser Diffraction, Dynamic Light Scattering, Optical Microscopy, Nano Tracking Analyses, Asymmetric Flow Field Flow Fractionation (AF4).Antigen comparability study after manufacturing changes and different clinical phase’s production.Support for investigation related to improvement in manufacturing production, in-process studies, new working seed implementation.Use of the Sentry Quality Platform for Change Request and Deviation report management. Show less

Synthesis, characterization and applications of novel amphiphilic derivatives of nucleosides