Simon Benoit Email & Phone Number

Paris, Fr

Paris, Fr

Paris, Île-De-France, France

Physiologic and molecular determinant of brain susceptibility to reward- and metabolic-based diseases.

Bordeaux, Nouvelle-Aquitaine, France

Investigating the role of the dopaminergic system in the links between early-life adversity, obesity, and depression.

Cambridge, United Kingdom

Paris Area, France

⇒ Amino acids bioavailability of lactoserum and zein proteins in healthy volunteers and ileostomised volunteer.Comparison of the digestibility of animal and vegetal sources of protein in human volunteers.Supervision of 2 postgraduate students.- Keywords: amino acids bioavailability, clinial study, digestion, DIAAS- Lab models & techniques: clinial studies (ileal tube), EA-IRMS, UPLC→ Laboratory: Nutrition Physiology and Ingestive Behaviour,Team: Protein Metabolism, Energy Homeostasis and Feeding Behaviour,(AgroParisTech/INRA, UMR 914)

Nancy Area, France

Teaching in the first year of DUT in bio-engineering : general biology (animal and vegetal physiology), animal taxonomy, IT-tools (Word, PowerPoint & Excel)Supervision of tutored projects on sugar addiction

Paris / Nancy

⇒ Impact of the administration of α-casozepine, a benzodiazepine-like peptide from bovine αs1-casein, and of a proteolysis fragment on neural activity in mice.Alpha-casozepine is a decapeptide (YLGYLEQLLR) mediating the anxiolytic-like properties of a tryptic hydrolysate of bovine αs1-casein. Different properties of α-casozepine leads to consider this peptide close to the benzodiazepine family, the most commonly used anxiolytic molecules. In contrast, other results suggest a distinct mode of action between α-casozepine and benzodiazepines, especially the fact that the peptide does not have side effects. Although a central action remains the main hypothesis of the mode of action of α-casozepine, no regulation of the brain activity has been shown before.The work achieved in this thesis displayed the fact that the anxiolytic-like properties of α-casozepine, after a single intraperitoneal injection of the peptide, are associated with a modulation of cerebral activity in several regions linked to anxiety regulation in mice brains. Besides, the modulations of neural activity are not exactly the same as those obtained after an injection of diazepam, a reference anxiolytic, or a derivative of α-casozepine, even though observed behaviours are similar.This work allowed a better understanding of the mode of action of a bioactive peptide from alimentary origin that has a positive action on its consumer’s mood and behaviour.- Keywords: α-casozepine, bioactive peptide, anxiety, neural activity, animal behaviour- Lab techniques: Animal model (mouse), behaviour, brain sectioning, immunofluorescence, → Laboratory: Nutrition Physiology and Ingestive Behaviour,Team: Protein Metabolism, Energy Homeostasis and Feeding Behaviour,(AgroParisTech/INRA, UMR 914) → Laboratory: Animals and Animal Products’ Benefits,Team: Proteolysis & Biofunctionalities of Proteins and Peptides,(Université de Lorraine/INRA, UC 340)

Paris

⇒ The effects of chronic ingestion of sugar-sweetened drinks on feeding behaviour and satiety in obesity-prone and obesity-resistant mice.The objective of this study was to understand the consequences of chronic sugar-sweetened water consumption on a model of mice sensitive to obesity (Obesity-Prone/Obesity-Resistant mice), given different physiological parameters.- Keywords: Appetite, weight gain, binge eating, homeostatic control, animal models- Lab techniques learned: Animal model (mouse), blood samples, DEXA, calorimetry→ Laboratory: Nutrition Physiology and Ingestive Behaviour,Team: Protein Metabolism, Energy Homeostasis and Feeding Behaviour,(AgroParisTech/INRA, UMR 914) → Laboratory: Olfaction Neurobiology and Imaging Modeling,Team: Analysis and Modeling applied to Biological Imaging,(INRA, Unité 1197)

Newcastle-Upon-Tyne, Uk

⇒ The effects of physiological changes (ageing) and environmental factors (diet) on Nucleotide Excision Repair (NER) activity.This study’s goal was to analyse the impacts of ageing and caloric restriction on four genes expression (XPA, XPC, ERCC1 and ERCC5) involved in the Nucleotide Excision Repair pathway in the mice liver. - Keywords: Ageing, caloric restriction, DNA repair, epigenetic, molecular biology- Lab techniques learned: RT-qPCR, pyro-sequencing, comet assay→ Team: Healthy Ageing, Lifestyle and Nutrition

Master Of Science (M.Sc.), Specialisation In Human Nutrition & Health, With Honours

Ph.D., Human Nutrition

Diplôme D'Ingénieur Agronome / Life Science Engineer Diploma, Specialisation In Human Nutrition & Health

Activities and Societies: Vice-President of the Student Association, in charge of cultural associations and activities

Classes Préparatoires (Preparatory School) To The French “Grandes Ecoles” - Bcpst

Biology, Chemistry, Physics, Mathematics, Earth sciences

Baccalauréat (National French High School Diploma), Specialisation In Sciences, Concentration In Mathematics, With Hounours