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Our goal is to comprehensively characterize and compare the cellular processes as well as the gene-environment interactions occurring in MODY disorders, with emphasis on identifying a general, age-related, mechanism of disease onset.Based on extensive experience with mouse genetics, cell fate characterization and age-related molecular mechanisms, our research group aims to: (1) characterize β-cell failure in several MODY types; (2) establish the role of the pancreatic niche during diabetes onset and progression; (3) examine the influence of age and aging on β-cell failure; (4) reverse the molecular age-switch controlling the homeostatic gradual impairment and proliferation quiescence in β-cells; (5) characterize the cellular mechanisms underlying the natural and gradual decay of iPSC-derived β-cells from MODY patients.The lab is funded by generous grants from the Novo Nordisk Foundation, The Research Council of Norway, Diabetesforbundet and is part of the Center for Diabetes Research at the Department of Clinical Science, University of Bergen, Norway.
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ProfessorUniversity Of Bergen (Uib)Bergen, Vestland, No -
ProfessorUniversity Of Bergen (Uib) Sep 2020 - PresentBergen, Norway
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Ncmm Associate InvestigatorUniversity Of Bergen Oct 2015 - PresentNorwayRenewed in 2020. NCMM is the Norwegian node of the Nordic EMBL Partnership for Molecular Medicine. The partnership between the European Molecular Biology Laboratory (EMBL), the Centre for Molecular Medicine Norway (NCMM), the Danish Research Institute of Translational Neuroscience (DANDRITE), the Institute for Molecular Medicine Finland (FIMM), and the Laboratory for Molecular Infection Medicine Sweden (MIMS) is dedicated to the growing field of life sciences that investigates the molecular basis of disease and explores treatments based on molecular and genetic approaches.
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Associate Professor (Førsteamanuensis)University Of Bergen Jun 2016 - Sep 2020Bergen Area, NorwayHaving a strong background in mouse genetics, β-cell biology, cellular plasticity, regeneration and diabetes, my research focuses on understanding the causes of the progressive β-cell decay occurring in pathologic conditions like MODY (Mature Onset Diabetes of the Young). In this context I study the role of senescence in gradual β-cell failure and diabetes onset in mice and humans. https://chera.w.uib.no/
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Postdoctoral FellowUniversity Of Bergen Mar 2015 - Jun 2016Department Of Clinical ScienceTo enlarge my experience with stem cell derived pancreatic cell lines, I recently moved to Bergen to collaborate with Prof. Helge Ræder on a project involving the differentiation of pancreatic β-cells from human induced pluripotent stem cells, derived from fibroblasts donated by patients with Mature Onset Diabetes of the Young (MODY).
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Invited ProfessorUniversity Of Geneva Sep 2020 - PresentGeneva, SwitzerlandCollaboration with Dr. Charna Dibner -
Postdoctoral FellowUniversité De Genève Oct 2008 - Feb 2015Department Of Genetic Medicine And DevelopmentCharacterized two age-dependent regenerative mechanisms involved in spontaneous murine pancreatic regeneration (Chera et al., 2014 Nature; Thorel et al., 2010 Nature). Briefly, I found that prepubescent mice always recover from diabetes after near-total β-cell ablation, however through a completely novel cellular mechanism: the massive recruitment and dedifferentiation of another hormonal cell type (δ-cells) to a very early progenitor stage. These cells re-enter the cell cycle and recapitulate embryonic development to become insulin producers. Moreover, by characterizing the molecular differences between the adult and the juvenile regenerative mechanisms, it was possible to pharmacologically trigger the extremely efficient juvenile regenerative program in adult diabetic mice. http://www.unige.ch/medecine/gede/en/research-groups/522herrera/
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Phd StudentUniversité De Genève Nov 2002 - Jun 2008Department Of Genetics And EvolutionMy PhD work was focused on the characterization of the molecular and cellular basis of regeneration and homeostasis in one of the best-known regenerative model systems, hydra. As result, we uncovered an unexpected level of complexity governing hydra head-regeneration involving an apoptosis-driven Wnt3a-induced surge of dedifferentiation followed by compensatory proliferation required for an efficient regenerative response. This discovery triggered a paradigm shift, challenging the classical views of hydra regeneration and introducing for the first time in the regenerative field the idea of a dual program of regeneration depending on environmental and internal cues (Chera et al., 2010 Dev. Cell).http://genev.unige.ch/en/users/Brigitte-Galliot/unit
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Frequently Asked Questions about Simona Chera
What company does Simona Chera work for?
Simona Chera works for University Of Bergen (Uib)
What is Simona Chera's role at the current company?
Simona Chera's current role is Professor.
What is Simona Chera's email address?
Simona Chera's email address is simona.chera@uib.no
What skills is Simona Chera known for?
Simona Chera has skills like Diabetes, Molecular Genetics, Molecular And Cellular Biology, Cell Signaling, Genome Sequencing, Regenerative Medicine, Mouse Models, Aging, Cellular Plasticity, Beta Cell Biology, Immunofluorescence, Fluorescence Microscopy.
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Simona-Liliana Chera
Carlow -
simona chera
Romania -
Simona C. Chera
Bucharest, Romania
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