Simone Degan Email & Phone Number

Durham, Nc, Us

Durham, North Carolina, Us

• Ongoing research on:- chemotherapy studies targeting mutant BRAF and autophagy inhibitors and pharmacokinetics of the agents - phatobiology of the diseases - neurodegenerative diseases (e.g. Alzheimer's, Parkinson's)• Experienced with a number of animal tumor models e.g. cutaneous, respiratory, brain, breast, cardiovascular• Developing animal tumor models such as:- orthotopic skin xenotransplantation (human skin into mice) for melanoma studies, - lung tumor mice models.• Performing survival microscope surgery examples include: - arterial cannulation in the femoral artery for blood pressure and respiration monitoring -for cranial surgery,- left anterior descending (LAD) Coronary Artery Ligation,- ovariectomy, - thymectomy, - spinal cord injury, - animal tumor models using the dorsal window.• Brain surgery examples include:- intracranial brain surgery for electrophysiology to study spreading depressions,- electrode implantation for stimulation, - intracerebroventricular injections (icv).• In vivo animal imaging:- PET/CT scans on animals using radiotracers for tumor diagnosis and quantification,- MRI,- Non-linear optical microscopy protocols for in vivo detection of tumor lesions during tumor progression,- developing ad hoc platforms for computational quantitative assessment for immunoperoxidase staining,• Animal necropsy and histology tissue assessment• Molecular biology protocols (e.g. RNA, qPCR, WB)• Animal protocols:• IACUC animal protocols preparation/review/submission for IACUC approvalPrincipal investigator in the animal protocols and responsible for the quality regulatory compliance of the protocols and semiannual site visits

Durham, North Carolina, Us

• Courses and workshops on pedagogy BIO390 Teaching Biology, as well as GS302 College Teaching• Faculty mentorship for semester-long mentorship with a faculty member to gain exposure to and insight about a different learning environment• Practical teaching experience teaching in in Evolutionary Anthropology 133L and an informal histology course for chemistry graduate students, as well as • Evaluation of teaching• Completion of the teaching portfolio• Supervised breeding and maintenance of transgenic animal used in the pathobiology of lung diseases

Durham, North Carolina, Us

• Conducted research on respiratory diseases in infants and adults with major focus on asthma, radiation lung injury, and chronic lung disease of premature newborns (Bronchopulmonary Dysplasia).• Performed in vitro and in vivo cell and molecular biology based research using animal models (rodent and primates), and human specimens.• Taught experimental protocols to student and technicians. • Developed orthotopic thymus xenotransplantation technique to implant baboon tissue into immunosuppressed mice.• Responsible for day-to-day laboratory operations..• Developed platform plugins for the automatic quantitative assessment of the level of staining for a specific antibody staining and morphological measurements.

Cranfield, Bedfordshire, Gb

• Investigated novel markers to detect the molecular changes that take place in the breast tissue during the transition from benign cellular atypia to frank malignancy (in vitro and translational).• Developed molecular biology, immunology, and pathology protocols for in vitro and human fresh tissue.

• Responsible for providing scientific and technical advice to physicians.• Coordinated research study protocols and presentation of quarterly results to upper management.• Complied with protocol guidelines and requirements of regulatory agencies.• Contributed to registering a new prophylaxis drug in the Italian National Health Registry.

Certificate In Teaching College Biology, Secondary Education And Teaching

Doctor Of Philosophy (Phd), Pathology And Cancer Biology