Simone Dedola Email and Phone Number
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Lead Scientist with hands on experience on chemical synthesis and bioconjugations. Exploiting the strong organic chemistry background paired with the solid experience in protein chemistry and glycoconjugation is my daily job at Iceni Diagnostics. All is glued together by leadership attitude and the essential positive spin to push projects forwards against the always misbehaving chemistry.
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General ManagerIceni Glycoscience (Formerly Iceni Diagnostics)Norwich, England, Gb
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General ManagerIceni Glycoscience (Formerly Iceni Diagnostics) Jan 2021 - PresentNorwich, England, United Kingdom -
Lead ScientistIceni Diagnostics Oct 2015 - PresentNorwich Research ParkMy research at Iceni Diagnostics pivots around the synthesis of carbohydrate moieties to be used for POC device and vaccine development. - Lead and coordinate the chemistry team - Synthetic route development, scale up process optimization from mgs to multi grams - New bioconjugations methodology development - Responsible for H&S management and staff training- Manage and organize laboratory - Grant application drafting with costing and resources allocation - Industrial supervisor of PhD, Erasmus, and project students with different expertise from undergraduates to post-graduates- First employ of Iceni Diagnostics: Lab and office set-up and organization (IT structure, office organization, laboratory equipment purchase with strong negotiations skills)
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General ManagerIceni Glycoscience (Formerly Iceni Diagnostics) Oct 2015 - PresentNorwich, England, United Kingdom
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Postdoctoral Research AssistantJohn Innes Centre Jul 2015 - Sep 2015Norwich, United KingdomCarbohydrate chemistry, glycosylation, click chemistry, -
Post-DocOsaka University Apr 2010 - Apr 2015Osaka, Osaka, JapanDuring the past five years I have been investigating about the glycoprotein quality control system in the Endoplasmic Reticulum (ER). Several aspect of the glycoprotein folding in the ER are still unknown, and my research has been focused on the design of model glycoprotein able to form correctly folded and misfolded species in a controlled manner to investigate the interaction with ER quality control system enzymes. Recently I have been studying the preparation of Sep15, an ER resident selenocysteine protein, which seems to have an oxido-reductase function, but which role it is still not defined. Such protein has been already prepared in the past, but using cysteine in place of the selenocysteine, which we believe is essential to clearly understand its function. -
Post-Doc Jsps FellowNational Institute Of Advanced Industrial Science And Technology Mar 2009 - Mar 2010During the JSPS research fellowship in Japan my work was based on the application of microwave irradiation to improve the synthesis of Gold Colloidal NanoParticles (GCNPs). Following the report of the application of the GCNPs as solid support for solid phase carbohydrate synthesis the ultimate goal of the research theme was to develop and improve the synthesis of the GCNPs and their application in order to build a versatile and solid water-soluble platform to be used for carbohydrate solid phase synthesis, enzymatic reaction, and direct biological assay.
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PhdUniversity Of East Anglia 2005 - 2009Norwich, United KingdomMy Ph.D. research focused on application of “click chemistry” to modify carbohydrates. The project was mainly dedicated to the synthesis of reversible and irreversible glycosidase inhibitors. The main targets of the reversible inhibitors were the different glycosidases involved in the starch metabolism in the barley seeds. The irreversible glycosidase inhibitors were envisioned to work as tools for understanding glycosidases mechanism or to be used for post translational modifications of proteins. In addition to the main theme, I have been also working on the enlargement of the sugar chain of small potential glycosidase inhibitors by using chemo-enzymatic synthesis, in order to target enzyme with extended binding site (i.e. β-glycosidase) and on synthesis of pseudo-starch fragments by Cu (I)-catalyzed Huisgen’s 1,3-dipolar cycloaddition (“click” chemistry).
Simone Dedola Skills
Simone Dedola Education Details
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Carbohydrate Chemistry
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Peptide Chemistry
Frequently Asked Questions about Simone Dedola
What company does Simone Dedola work for?
Simone Dedola works for Iceni Glycoscience (Formerly Iceni Diagnostics)
What is Simone Dedola's role at the current company?
Simone Dedola's current role is General Manager.
What is Simone Dedola's email address?
Simone Dedola's email address is si****@****ahoo.it
What schools did Simone Dedola attend?
Simone Dedola attended University Of East Anglia, Università Degli Studi Di Sassari.
What are some of Simone Dedola's interests?
Simone Dedola has interest in Social Services, Children, Economic Empowerment, Civil Rights And Social Action, Politics, Education, Environment, Poverty Alleviation, Science And Technology, Disaster And Humanitarian Relief.
What skills is Simone Dedola known for?
Simone Dedola has skills like Peptide Synthesis, Carbohydrate Chemistry, Synthetic Chemistry, Organic Chemistry, Nmr, Biochemistry, Hplc, Protein Purification, Protein Chemistry, Lc Ms, Chemistry, Protein Expression.
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