In my experience at Boston University, we focused on the intricate bioinformatics analysis of ncRNA cluster, where I honed my expertise in differential expression analysis using tools like DiffBind and EdgeR. Contributing to the understanding of epigenetic marks, I've developed a proficiency in pathway analysis, enriching my knowledge of KEGG and GO pathways using ClusterProfiler and ChIPseeker packages in R. Currently, I'm also practicing scRNA-seq data analysis using both Python and R, learning about the integration of NGS analysis with the wet-lab results to obtain and validate our research goals and objectives. With a background in Microbiology, my journey transitioned from medical lab technology, where we processed COVID-19 samples using RT-PCR, to a fascination with bioinformatics. As I pursue my Master's degree, my goal is to delve deeper into this field, leveraging my skills in data analysis to contribute to advancements in precision medicine and cancer therapeutics.
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Ngs Bioinformatics AnalystPfizerBoston, Ma, Us -
Data Science InternWhitehead Institute Sep 2024 - Dec 2024Cambridge, Massachusetts, United StatesResponsible for RNA-seq data analysis of iPSC-derived stem cells (MSNs) for discovering differential genes in the cells exposed to opiods at 3 timepoints.Validate the findings using external data and determine Mahalanobis distance between ex-vivo and iPSC stem cells.Advanced proficiency in scRNA-seq data analysis using Seurat and developed efficient workflows with Snakemake for scalable bioinformatics pipelines. -
Bioinformatics Research InternBoston University School Of Medicine Jun 2024 - Aug 2024Whitaker Cardiovascular Institute, Jingyan Han LabRedox omics project:The project was focused on discovering the role of the Glrx enzyme which is known to play a crucial role in redox signaling in vascular endothelial cell dysfunction in response to various risk factors including hyperlipidemia, aging, and chronic alcohol abuse. We look forward to performing WES/WGS data analysis on three layers: RNA-seq, scRNA-seq, and ATAC-seq of Glrx-KO mutant endothelial cells to understand the crucial role of this enzyme at the molecular level and its association with other regulatory pathways that are impacted due to vascular diseases. -
Bioinformatics Research AssistantFaculty Of Computing & Data Sciences At Boston University Dec 2023 - May 2024Life Sciences And Engineering Building, Frank Naya LabMulti-omics project:Spearheaded the bioinformatics analysis of ATAC-seq and CUT and RUN data sets of the Dlk1-Dio3 locus of the ncRNA cluster. Implemented different methods- DiffBind, csaw, and EdgeR packages to execute differential expression analysis of ATAC seq data.Gained the experience of utilizing Bash to create a counts matrix from the provided Bam and narrowPeaks files. Facilitated the CUT&RUN analysis to run pathway analysis- KEGG and GO enrichment also further determined DE genes affected due to H3K27 and H3K47 Tri-Methylation marks. -
Medical Laboratory TechnicianPostgraduate Institute Of Medical Education And Research (Pgimer), Chandigarh May 2021 - Apr 2022Lucknow, Uttar Pradesh, IndiaMy role as a medical lab technologist included processing of COVID-19 samples from the assigned districts as well as from the hospital which included inactivation, mechanical RNA isolation and running RT-PCR. -
Research Microbiologist InternPostgraduate Institute Of Medical Education And Research (Pgimer), Chandigarh Jan 2021 - May 2021Lucknow, Uttar Pradesh, IndiaThe thesis research intended to elucidate the correlation between the effect of infection by the TORCH group of microorganisms namely- Toxoplasmosis, others, Rubella, Cytomegalovirus, and Herpes Simplex Virus (HSV) in pregnant women. The research methodology was preceded by the collection of data about cases where miscarriages occurred due to the detection of TORCH infections in the womb and also post-birth infection in neonates.The major techniques used for the detection of pathogens were ELISA and PCR for CMV. The study showed that infection by CMV in the early stages of embryo development can be fatal or may lead to severe abnormalities in neonates and is the most frequent causal organism of infection among others.
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Research InternAmity University Lucknow Campus Oct 2020 - Dec 2020Lucknow, Uttar Pradesh, IndiaWorked on the project focused on studying alkylation stress response in Mycobacteria by using Methyl methanesulfonate as a methyl donor. I researched how bacteria evoke physical defense mechanisms by amplifying biofilm formation. After differential proteomics studies, it was established that GlmU, a bifunctional enzyme plays a vital role in the increase of biofilm formation amongst all the upregulated proteins. The hypothesis was further tested with replicate species of M. smegmatis Ms::glmU merodiploid strain and Ms*glmU conditional deletion mutant strain, results of which dignify that its upregulation caused a significant increase in biofilm formation.
Simran Singh Education Details
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First Class In Distinction
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First Class In Distinction -
First Class In Distinction -
Kilbil St. Joseph'S High SchoolFirst Class In Distinction
Frequently Asked Questions about Simran Singh
What company does Simran Singh work for?
Simran Singh works for Pfizer
What is Simran Singh's role at the current company?
Simran Singh's current role is NGS bioinformatics analyst.
What schools did Simran Singh attend?
Simran Singh attended Boston University, Amity University Lucknow Campus, Savitribai Phule Pune University, H.p.t. Arts And R.y.k. Science College, Kilbil St. Joseph's High School.
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Simran Singh
Biopsychology, Cognition, And Neuroscience Student At The University Of MichiganDetroit Metropolitan Area -
Simran Singh
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