Si Yi Z. Email and Phone Number

• Served as Project Lead and Biology Lead for core early-stage pipeline projects• Managed and coordinated team with members from different cross-functional groups; led and organized team meetings to move projects forward to and through critical decision points• Coordinated with academic collaborators, initiated and managed contracts, oversaw project progression and updates• Presented projects to wide range of audience• Performed key cell-based, high-throughput, and in vivo experiments for projects• Worked with multiple CROs to aid in compound series characterization and optimization• Oversaw duties of direct report; mentored junior members in experiment design and data analysis• Assisted in different cell-based assays and in vivo studies as needed for multiple other projects

• Led early discovery pre-clinical pipeline project• Managed team meetings and activities• Optimized SAR of lead compound series based on PK/PD relationships, cell-based in vitro assays, and in vivo experiments using genetically modified mouse models• Used aseptic techniques to culture cell lines and to process patient samples• Designed, analyzed, interpreted data from multicolor flow cytometry panels• Identified, coordinated, liaised with CROs based on various experimental needsGBT was acquired by Pfizer in October 2022

Thesis title: The Functional Interplay Between PTEN and PDK1 in Acute LeukemiaPrincipal investigator: Chi Wai Eric So, Ph.D.• Investigated the role of PTEN and PDK1 in hematopoiesis and leukemogenesis by performing in vivo studies using inducible knockout models • Assessed effects of disease on different hematopoietic cell populations post transplantation by RNA-sequencing, serial transplantations, survival analyses, health surveillance, and anatomy/histopathology

Principal investigator: Peter Parker, D.Phil., F.R.S.• Carried out various methods and tactics in identifying possible kinases responsible for activation of the AKT pathway using human cell lines• Developed and conducted pharmacokinetic studies using molecular biology methods• Evaluated cell signaling by use of small-molecule inhibitors• Conducted high-throughput screens using inhibitor libraries• Manipulated gene expression and function via siRNA, overexpression, and transfection with target validation• Collaborated with GlaxoSmithKline on competitive kinase profiling assay

Principal investigator: Emmanuelle Passegué, Ph.D.• Developed an immunofluorescence approach to identify and characterize different stem/progenitor cell populations within murine bone marrowIn vivo (mouse) skills: colony husbandry, dissection/bone extraction, injections (intra-femoral, intraperitoneal, retro-orbital, subcutaneous, tail vein), irradiation/transplantation, parabiosis, perfusion, bleeds (submandibular, retro-orbital, tail vein), sample collection with DNA extraction for genotypingCo-lab manager

Principal investigator: Daniel Panne, Ph.D.• Determined functional properties and correlation between Cohesin subunits, with main focus on key acetyltransferase of the complex

Principal investigator: Eric Lam, Ph.D.• Assessed effects of SIRT1 and BCR-ABL oncoprotein inhibition with EX527 and Imatinib on cell vitality and proliferation with leukemia K562 cell lines

• Prepared complex media required for stem cell culture and polyacrylamide gels for protein analysis

Supervisor: Mark Barnby, Ph.D.