Providing biological insights for planning and support.Curating biological datasets for AI-based drug discovery and computational analysis to reprogram immune responses.

Postodctoral researcher in the lab of Prof. Cedric Feschotte, department of Molecular Biology and Genetics researching on HIV and Human endogenous retorviruses (HERVs) as a part of the HIV Obstruction by Programmed Epigenetics (HOPE) Collaboration, with a goal to silence and eliminate latent HIV by understanding how the ancient remnants, HERVs are inactivated in the genome. Interested in elucidating mechanism of antiviral protein in HIV-1 infection. Other research focus is on understanding the cross talk between endogenous and exogenous viruses in B cell lymphoma, involving HIV/AIDS and EBV infection

As I moved to new lab, which was just started in Tübingen, I learnt a lot and supported in setting up and organizing the lab. Establishing and optimizing protocols in a new lab setup, collaborating and networking in the Department were part of the postdoc. Laboratory management was a skill I gained alongside continuing research on HIV, SARS CoV-2 and human endogenous retroviruses in Prof. Daniel Sauter's group. Research projects: Identification of cellular genes regulated by HIV-1 induced Endogenous retroviruses (ERV). Analyzing the role of HIV-1-induced ERV and cellular gene in infection and immunity.Role of antiviral protein in Syncytin mediated fusion of trophoblast cells

In the lab of Prof. Dr. Daniel Sauter and Prof. Dr. Frank Kirchhoff, I researched to determine the effects of primary HIV-1 strains on the expression of HERVs in a global and unbiased manner and to identify cellular genes that might be regulated by endogenous retroviruses. I found that HIV-1 infection activates endogenous retroviral LTR12C promoters regulating antiviral gene expression of Guanlylate binding proteins (GBP2 and GBP5)Dissertation : HIV-1 infection induces endogenous retroviral promoters regulating antiviral gene expression

Thesis: Role of EZH2 (Enhancer of Zeste Homolog 2) In B cell leukemogenesis The aim of the project was to Investigate the molecular mechanisms of leukemogenic effect of EZH2 repression in MYC driven B-lymphomagenesis .We found that EZH2 inactivation potentiates MYC-driven leukemogenesis by blocking differentiation at pre-B-cell stage. Demonstrated the role of EZH2 in H3K27 tri-methylation. Further, we estimated the danger of reprogramming of B-cell lymphoma into pre-B cell leukemia by EZH2 inhibitors.Our results adds to the understanding the role of EZH2 inactivation in B cell acute lymphoblastic leukemia.

Analysis of inflammatory responses through activation of Toll Lile Receptor 5 by flagellin from Salmonella typhi The aim was to understand the signal transduction of Toll-like-receptor-5 activation by bacterial antigen called flagellin. Cytokine production upon interaction with flagellin and TLR5 was identified and analysed. We observed a dose and time dependent increase in the production of IL-8 upon flagellin treatment. TNF alpha production was analysed and observed early immune response upon flagellin addition.My fellowship was sponsored by Indian Academy of Sciences and I was a fellow in Dr. Ayub Qadri's lab