Sofia Mayans Email & Phone Number

Umeå, Se

Umeå, Västerbotten County, Sweden

Umeå, Västerbotten, Sweden

Umeå, Västerbotten, Sweden

Umeå, Sweden

Fibrosis, or scar tissue formation within an organ, contributes to more than 40% of deaths in the industrial world and despite this huge impact on human health, no efficient anti-fibrotic drugs are currently available on the market. One caveat in the development of anti-fibrotic drugs is the lack of good and reliable pre-clinical models for testing of substances under development.InfiCure Bio (www.inficurebio.com) is a preclinical CRO located in the north of Sweden and the company has… Show more Fibrosis, or scar tissue formation within an organ, contributes to more than 40% of deaths in the industrial world and despite this huge impact on human health, no efficient anti-fibrotic drugs are currently available on the market. One caveat in the development of anti-fibrotic drugs is the lack of good and reliable pre-clinical models for testing of substances under development.InfiCure Bio (www.inficurebio.com) is a preclinical CRO located in the north of Sweden and the company has a unique pre-clinical model, the NIF mouse, which spontaneously develops fibrosis in multiple organs. InfiCure Bio offers their clients to test the effect of their new anti-fibrotic drugs on the fibrosis in the NIF mouse.2019 - winner of category "Årets Nya Företagare" at Umeågalan.2018 - finalist "Årets University Spin-off" at Umeågalan Show less

Umea, Sweden

Development of fibrosis is associated with several disorders as well as life-style factors and affects multiple organs including the heart, liver, lungs and kidneys. Fibrosis is the formation of excess connective tissue in the affected organ, which in the end leads to organ failure. While contributing to approximately 40 percent of deaths in the industrial world, no effective anti-fibrotic drugs are available on the market. One caveat in the development of anti-fibrotic drugs is the lack of… Show more Development of fibrosis is associated with several disorders as well as life-style factors and affects multiple organs including the heart, liver, lungs and kidneys. Fibrosis is the formation of excess connective tissue in the affected organ, which in the end leads to organ failure. While contributing to approximately 40 percent of deaths in the industrial world, no effective anti-fibrotic drugs are available on the market. One caveat in the development of anti-fibrotic drugs is the lack of good and reliable pre-clinical models for testing of substances under development.InfiCure Bio has a unique pre-clinical model, which spontaneously develops fibrosis in multiple organs. The model will be used to test the effect of anti-fibrotic substances under development. The company is based on the access to this unique pre-clinicalmodel in combination with the inventors’ expertise in the field of inflammation and fibrosis and their experience in effect testing. The business strategy is to identify and approach drug developing companies with focus on anti-fibrotic substances and offer them to test their substances in this unique model. Show less

Umeå, Sverige

Clinical Microbiology, Immunology

San Diegoområdet, Usa

In 2011, I started my Postdoctoral position, funded by the Swedish Research Council, in the group of Professor Hilde Cheroutre at La Jolla Institute for Allergy and Immunology (LIAI), San Diego, USA. My work at LIAI was focused on early thymocyte development and analysis of intraepithelial lymphocyte subsets. In one project, we studied early thymocyte development in NOD and B6 mice. The aim of the project was to elucidate which effect genetic variations in genes important for T cell… Show more In 2011, I started my Postdoctoral position, funded by the Swedish Research Council, in the group of Professor Hilde Cheroutre at La Jolla Institute for Allergy and Immunology (LIAI), San Diego, USA. My work at LIAI was focused on early thymocyte development and analysis of intraepithelial lymphocyte subsets. In one project, we studied early thymocyte development in NOD and B6 mice. The aim of the project was to elucidate which effect genetic variations in genes important for T cell development have on signalling strength in the thymus. Changes in signalling strength will have an effect on selection events and this determines the amount of auto-reactive cells exiting to the periphery. In another project, we isolated intraepithelial lymphocytes from the small intestine and analyzed both induced and natural subsets. The aim of this project was to elucidate the MHC restriction of natural CD4- CD8αβ- TCRαβ+ intraepithelial lymphocytes. This work was carried out in retrogenic mice on different MHC-/- backgrounds and we found that the cells were restricted to a diverse set of MHC class I molecules (Mayans S et al. Immunity, 2014). During my time as a Postdoctoral fellow at LIAI I was one of the authors of a book chapter on intraepithelial lymphocytes (http://www.els.net/WileyCDA/ElsArticle/refId-a0001197.html). Show less

During my postdoctoral work at The Faculty of Science, University of Copenhagen, and Medical Biosciences, Umeå University, I have been using the non-obese diabetic (NOD) mouse as a model for human type 1 diabetes (T1D). I have also been using the technique of Optical Projection Tomography to visualize cells of interest in intact organs. In one study the method of Optical Projection Tomograpy was used to study and quantify the insulitis induced destruction of β-cells in the NOD mouse… Show more During my postdoctoral work at The Faculty of Science, University of Copenhagen, and Medical Biosciences, Umeå University, I have been using the non-obese diabetic (NOD) mouse as a model for human type 1 diabetes (T1D). I have also been using the technique of Optical Projection Tomography to visualize cells of interest in intact organs. In one study the method of Optical Projection Tomograpy was used to study and quantify the insulitis induced destruction of β-cells in the NOD mouse (Alanentalo T, et al. Diabetes, 2010). This technique was also used to support the finding that a specific disruption of Dicer 1 leads to impairment of insulin secretion and development of diabetes (Kalis M et al. PLos One, 2011). In a third project we used Optical Projection Tomograpy to image the effect of adaptive transfer of immunosuppressive Macrophages into NOD mice (Parsa R et al. Diabetes, 2012). Our studies of the NOD mouse resulted in the discovery of a novel diabetes susceptibility region, idd28, on chromosome 1. One candidate gene in the region is Cd247, which codes for the CD3ζ subunit of the CD3 complex. We did also show that congenic mice on NOD background harboring the Cd247 gene from B6 have reduced incidence of diabetes compared to littermate controls (Lundholm M et al. J Immunol, 2010). Show less

The main focus of my thesis work was to find genetic factors mediating T1D, as well as, Type 2 diabetes (T2D) in families from northern Sweden. I was part of a team which collected a family material, mainly originating from Norrbotten, which have multiple family members affected with T1D and/or T2D. A genome-wide linkage analysis has been completed on the T1D family material (unpublished data) in order to find genetic regions contributing to disease development in the families. The… Show more The main focus of my thesis work was to find genetic factors mediating T1D, as well as, Type 2 diabetes (T2D) in families from northern Sweden. I was part of a team which collected a family material, mainly originating from Norrbotten, which have multiple family members affected with T1D and/or T2D. A genome-wide linkage analysis has been completed on the T1D family material (unpublished data) in order to find genetic regions contributing to disease development in the families. The material has also been used to confirm a previously published association between the CTLA4 gene and T1D (Mayans, S et al. BMC Med Genet, 2007). A Genome-wide linkage analysis on the T2D families, revealed linkage to the previously identified Calpain-10 region (Einarsdottir, E et al. Diabetes, 2006). In the same cohort, we also confirmed association of variants of the TCF7L2 gene to T2D in the northern Swedish population (Mayans, S et al. Eur J Hum Genet, 2007). Show less

During my postdoctoral work at The Faculty of Science, University of Copenhagen, and Medical Biosciences, Umeå University, I have been using the non-obese diabetic (NOD) mouse as a model for human type 1 diabetes (T1D). I have also been using the technique of Optical Projection Tomography to visualize cells of interest in intact organs. In one study the method of Optical Projection Tomograpy was used to study and quantify the insulitis induced destruction of β-cells in the NOD mouse… Show more During my postdoctoral work at The Faculty of Science, University of Copenhagen, and Medical Biosciences, Umeå University, I have been using the non-obese diabetic (NOD) mouse as a model for human type 1 diabetes (T1D). I have also been using the technique of Optical Projection Tomography to visualize cells of interest in intact organs. In one study the method of Optical Projection Tomograpy was used to study and quantify the insulitis induced destruction of β-cells in the NOD mouse (Alanentalo T, et al. Diabetes, 2010). This technique was also used to support the finding that a specific disruption of Dicer 1 leads to impairment of insulin secretion and development of diabetes (Kalis M et al. PLos One, 2011). In a third project we used Optical Projection Tomograpy to image the effect of adaptive transfer of immunosuppressive Macrophages into NOD mice (Parsa R et al. Diabetes, 2012). Our studies of the NOD mouse resulted in the discovery of a novel diabetes susceptibility region, idd28, on chromosome 1. One candidate gene in the region is Cd247, which codes for the CD3ζ subunit of the CD3 complex. We did also show that congenic mice on NOD background harboring the Cd247 gene from B6 have reduced incidence of diabetes compared to littermate controls (Lundholm M et al. J Immunol, 2010). Show less

Doctor Of Philosophy - Phd, Human/Medical Genetics

Master Of Science (M.Sc.), Biology, General