Sonia Andersson Email & Phone Number

The purpose of this project is to identify women who are still at risk of developing virus-related gynaecological cancers by finding early markers that will permit rapid and focused prevention, and to increase biological knowledge of the factors that influence the development of cancer in HPV-infected women. It is important to understand the molecular mechanisms of carcinogenesis to improve early diagnosis, differential diagnosis, and evaluation of tumor aggressiveness, as well as to improve molecular markers in screening. Molecular markers will help differentiate between benign disease and malignancy, and thereby prove useful in clinical practice. Identification of protein expression patterns, including cell function-related isoforms in CC, PVC and VUC will contribute to the mechanistic understanding of these types of tumours, and to the optimization of current tumor diagnostics, as well as pave the way for the development of new treatment.Identification of persistent HPV infection in older women and those that not participate in the screening program offers a screening test with higher sensitivity and specificity to identify women at risk of developing cervical cancer. This will reduce the present over-diagnosis of women, contribute to a reduced overtreatment of non-malignant dysplasia and allow focus of the clinical management on the group of women at most need. By offering older women and the group of women who newer participated in the screening program by an option would increase the coverage and provide better protection against cervical cancer in older women. By including these risk patients in screening program the society may save many lives. Economic evaluation of different methods that are most clinically and cost effective for different patient groups must be the basis for a political decision. This knowledge can change the care of women with pre-invasive lesions of the cervix, and thus make more individualized treatment possible.

Listed skills include Life Sciences, Healthcare, Public Health, Medicine, and 17 others.

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  Professor In Obtetrics And Gynecology

  Karolinska University Hospital

  Jun 2012 - Present - Karolinska Institutet, Stockholm Sweden

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  Kalinin Medical University, Russia

  Obstetrics And Gynecology