Chen-Yen (Link) Yang, Ph.D. Email & Phone Number

San Francisco, California, Us

➤Project: “Develop a multi-class classification model to identify pancreatic cancer”● Created and optimized 6 different supervised algorithms in a multi-class classification campaign, including Logistic Regression, KNN, Decision Tree, Random Forest, Gradient Boosting, and Support Vector Machine Classifiers, achieving high performance metrics (accuracy: 78.8%, f1-score: 78.7%, log-loss: 58.2%).● Innovated and implemented an effective Support Vector Machine Classifier for early non-invasive cancer detection, rigorously evaluating model accuracy using a confusion matrix and prioritizing enhanced ROI for healthcare providers.➤Project: “Time series forecasting using ARIMA and PyCaret”● Performed thorough time series analysis and developed two predictive models (Seasonal ARIMA, Exponential Smoothing) using PyCaret that effectively leveraged historical data to make realistic forecasting.● Empowered strategic advertising decisions and ensured sustainable tourism development for the Tourism Bureau by creating a robust tool to understand past trends, predict future scenarios, and facilitate data-driven decision-making.

North Chicago, Illinois, Us

● Leveraged sophisticated data analytics to extract, format, and validate data from multiple sources, including published CRISPR literatures and large-scale data from DepMap, identifying 50+ high-potential tumor dependency targets.● Formulated hypotheses and analyzed experimental data for statistical inference, leading 4 cross-functional teams to make data-driven decisions and accelerating the ADC development pipeline by 20%.● Designed a multi-color FACS panel to quantitatively analyze high-dimensional dataset, identifying key biomarkers in apoptosis after drug treatment, leading to insights into post-treatment and streamlining the screening process by 30%.● Ensured data integrity and assay reliability through thorough data analysis and comparison, while innovating and refining cellular, biomarker and biochemical assays. Fostered collaborative trust among 6+ cross-functional teams.● Spearheaded the transition of inhibitor/degradomer/ADC programs into lead generation, steering 8+ projects in reaching critical go-no-go decisions, resulting in the successful identification of 3 viable drug candidates.

San Francisco, California, Us

➤Project: “Targeting Signaling Pathways in Cutaneous T-cell Lymphomas (CTCL) and Developing a Drug Discovery Platform Using Clinical Relevant Patient-derived Xenograft (PDX) Models”● Innovated to transform cell-free DNA data to quantify therapeutic interventions, developed novel PDX models that recapitulate human lymphoma and established a quantitative assessment highly correlated with tumor progression.● Cooperated with multiple pharmaceuticals to identify potential targets highly specific for CTCL and developed combinatory drug treatments to synergistically improve therapeutic efficacy which is being implemented in a phase I clinical trial for adults with relapsed or refractory cutaneous T-cell lymphoma.● Responsible for design, implementation and management of multiple research projects. Concurrently assisted graduate students and colleagues in statistical analysis, analytical software, mouse model and flow cytometry.● Conceived and executed experiments systematically, refined in vitro experimental procedures in cell line and murine/human primary cell culture, analyzed/interpreted results independently and troubleshoot effectively.● Demonstrated ability and enthusiasm to explore and master new technologies and methodologies.

Davis, California, Us

➤Dissertation: “A Comprehensive Study on Autoantibodies and Cytokines in Human and Murine Models of Primary Biliary Cirrhosis (PBC): Implications for Diagnosis and Therapy” ● Discovered a direct association between disease severity and Th1/Th17 balance that provides a promising target for PBC therapy. Identified novel serological markers that improve the efficacy of early PBC diagnosis.● Uncovered the presence of specific anti-nuclear antibodies (ANAs) against gp210 and sp100 in PBC mouse model, and thus justified the use of these mice for further clinical studies on the influence of ANAs in PBC.● Cooperated with multiple domestic and international research groups to execute, analyze, interpret experiments, and produce results that will benefit autoimmune patients and promote the collaboration between industry and academia.● Implemented scientific writing, troubleshooting skills and developed rational/feasible ideas to address and resolve critical problems.

● Worked as a bridge for members to connect with other Taiwanese affiliated organizations, provided academic and career consultation, and organized social activities to initiate networking between students and alumni.

Sacramento, Ca, Us

➤Project: “The Effects of Vitamin D Deficiency (VDD) on the Immune System” ● Established a VDD murine model, monitored serum vitamin D level, researched thymic miRNA expression profile in the VDD microenvironment, and investigated the effects of VDD on the population/function of immune T/B cells.● Led a comprehensive review of the role of vitamin D in autoimmunity and provided a condensed/relevant report that has received an elevated level of attention. Facilitated research process by working cooperatively, learning proactively, and multitasking efficiently with senior scientists.

Taipei, Northern Taiwan, Tw

➤Thesis: “In vitro Study on The Immuno-regulatory Effects of Micronutrients on Mice Sensitized and Oral Administered with Dust Mite Protein” ● Employed molecular biology techniques to isolate and purify recombinant dust mite protein, established a dust mite protein sensitized mouse model, and developed experiments to examine effects of various micronutrients on immune T cells.● Collaborated with undergraduates, supervised work progress, created an effective approach to maintain experimental documentation, assisted in experimental design, data analysis and small animal handling.

Taipei, Northern Taiwan, Tw

➤Project: “The Effects of Kiwi Fruit on Serum Cholesterol and Triglyceride in Wistar Rat with High Cholesterol Diet”● Assisted in the design of in vivo experiments and provided instruction on experimental procedures and data analysis. ● Taught bioanalytical techniques used in nutritional biochemistry and assisted undergraduate students with animal handling.

Taipei, Northern Taiwan, Tw

➤Project: The Stimulatory Effects of Chlorella on Macrophage and T Lymphocyte● Cooperated with Taiwan Chlorella Manufacturing Company to identify regulatory effects of chlorella on murine macrophage and T cell.

● Responsible for coordinating communications and data search of international intergovernmental agencies, troubleshooting technical issues, and all aspects of tour for foreign guests to Taiwan.

Taipei, Northern Taiwan, Tw

➤Project: “The Potential of Food Additives to Trigger Asthma on OVA-sensitized BALB/c Mice● Established an OVA-sensitized asthma mouse model, screened anti-OVA specific immunoglobulin E titer, and evaluated effects of metabisulfite on asthma.● Participated in the design of project, worked out experimental protocols and analyzed data in consultation with advisor.

Doctor Of Philosophy (Ph.D.), Immunology

Data Science Career Track Certificate

Master Of Science (M.S.), Microbiology And Biochemistry, Nutritional Science

Bachelor Of Science (B.S.), Biochemical Science And Technology