-Group leader in the lab of Dr. Vinit Mahajan‐Drug discovery and formulations for treatment of eye diseases.‐Gene therapy to cure eye disorders

- Project PI funded by National Research Foundation of Korea (NRF) - Supervision of PhD student and research associate in the group of Prof. Haeshin Lee

- Collaborators: Professor Jean-Christophe Leroux, Dr. Meriam Kabbaj, Dr. Vincent Forster, Dr. Valentina Agostoni, Dr. Giovanna Giacalone, Elena Moroz, Simon Matoori- Carrier-free oligonucleotide delivery for the treatment of intestinal disease- Development of pH-gradient functional vesicles- Collaboration with Versantis AG (ETH spin-off)(1) Rats and pigs in vivo study of pH-gradient liposome as an ammonia scavenger(2) Investigation of PEG effect on ammonica capturing and liposomal structure(3) Comparative stability study of liposomes formulated with different compositions

- Collaborators: Professor Jean-Christophe Leroux, Dr. Meriam Kabbaj, Dr. Vincent Forster, Dr. Valentina Agostoni- One of the main researchers of the Commission for Technology and Innovation (CTI) project for the development of pH-gradient liposome as an ammonia scavenger: collaboration with Versantis AG (ETH spin-off)- Optimization and validation of pH-gradient liposome manufacturing: stability, characterization, endotoxin/pyrogen assay, lipid quantification, buffer optimization, and scale-up study

- Collaborators: Elena Moroz, Dr. Bastien Castagner, Professor Jean-Christophe Leroux- Main researcher of the Gebert Rüf Stiftung project titled “a nucleic acid prodrug platform to study and treat rare colonic diseases”- Selection and evaluation of cell penetrating peptide for the intracellular delivery of macromolecules- Synthesis of peptide-nucleic acid conjugates and evaluation of their biological activity- Demonstration of in vitro gene silencing with nucleic acids targeting luciferase or ICAM-1 - Peptide modification with PEGs for colon-specific oral delivery- Synthetic polymer mediated siRNA delivery

Topic: Anticancer therapy with paclitaxel encapsulated siRNA micellesCollaborator: Professor Tae Gwan Park