I am a synthetic medicinal chemist with a comprehensive knowledge in Molecular biology (Aptamer Evolution) & Nucleic Acid Chemistry. I am currently working as a research scientist at Fannin Partners LLC’s aptamer therapeutic creative group based in Houston(TX) specialized in chemically modified Aptamer Evolution & their preclinical characterization, Synthesis of Aptamer-drug conjugates (ApDC), and Aptamer Radiochemistry. Key SkillsMedicinal Chemistry:• Synthetic Organic Chemistry: Designed & Synthesized Target orientated Benzazepine based small molecules by Diastereoselective & Asymmetric Synthesis.• Performed Lead optimization, SAR data analysis and have solid understanding of ADME & PK.• Have high level of expertise in State of art Analytical tools- 1D-, 2D- NMR, LC-Ms, GC-Ms, ESI, APCI, Analytical and Preparative HPLC (chemstation/OPENlab)• Performed Molecular modelling and Docking studies (MOE, Autodock Vina, PyMol).• Presented scientific data at various international conferences & Prepared manuscripts for publication. • Managed Chemical Inventory and Trained Undergraduate research assistants.• Handled Chemistry related software (Chemdraw/MestroNova), MS office.Molecular biology: • Worked on Mirror image directed evolution (SELEX) of L-DNA / L-RNA Aptamers.• Performed in-vitro selection of chemically modified DNA aptamers against various native RNA targets.• Screened aptamers affinity by Biolayer interferometry(BLI) and EMSA. • Expert in PCR, In-vitro transcription, DNA Sequence analysis (SnapGene, Geneious).• Carried out Solid phase DNA/RNA synthesis (ABI expedite), deprotection & purification.• Hand on experience with various Gel Electrophoresis methods(PAGE, Agarose, SDS PAGE).• Highly skilled for the Synthesis of Modified Nucleotide building blocks by phosphoramidite Chemistry.• Expert in Synthesis of Modified Nucleotide triphosphates & Method development of HPLC.• Have sound knowledge in Typhoon imaging, Oligo Radiolabeling, CuAAC click conjugation, Molecular Cloning. • Limited experience with Protein Expression and Purification. • Trained in Laboratory Safety Management & Supervised grad students/junior postdocs.• Environmental Health Safety trained for Radioisotope and Hazardous Chemical Handling.