Ensure top quality clinical pathology and histopathology work getting delivered to enable safety evaluation of chemicals and drugs

Responsible for histopathological evaluation of different toxicological studies with rodents.Target organ identification.Result compilation and report preparation

Invivo efficacy model, pathologist

significant contribution in:Establishing malaria efficacy model.Establishing discovery safety for TB and malaria projects with the support of GSA.Part of the team that submitted an IND to FDA.Actively involved in:Developing of acute Septicaemia model for testing broad spectrum antibacterial drugs and later on involved in working on PKPD of antiTB drugs in mouse aerosol TB model.Drug discovery in Infection TA. Responsible for providing safety inputs to the drug discovery process, involves safety evaluation of lead molecules for genetoxicity, cardiovascular toxicity and recognizing the safety flags early on to progress the right molecules for further development. Designing and conducting studies to identify target organ toxicity in preclinical settings with particular reference to class of compounds. Interacting with global safety assessment scientists and organize strategic meetings to shortlist molecules. Coordinating various activities starting from design to conduct and necropsy and preparation of quality histopathology slides for evaluation and conducting histopathology evaluation and coordinating peer review of these studies. Assessing the Health status of animals in the colony and preparing an exclusion list.Functioning as Member of ethics committee and organize and conduct of IAEC meetings.Mentoring /training Veterinarians.Designing / constructing, maintaining, managing of preclinical research–toxicology (to international standards–guidelines, fulfilling Good Laboratory Practice requirements).

Conducting necropsy, gross pathology and histopathology; compiling data and reporting as per GLP norms.Author (Study Pathologist) for around 45 confidential toxicology study reports, of various new compounds marketed or to be marketed. The type of studies conducted include:Sub chronic oral / dermal / inhalation / parenteral route toxicity study in rodents. These reports are submitted to various regulatory authorities of several countries, including FDA & EPA (USA), and Indian Regulatory Authorities.Undertaking SOP writing for various types of study and techniques.