Srishti Gurnani Email & Phone Number

Greater Boston Area

Immunology Program• Developed and optimized a cellular reporter-based on-target mechanistic assay that could detect bioactivity from fungal crude extracts. Delivered consistent, high-quality, reproducible cell data, aiding in the med-chem team's SAR strategy.• Identified sensitivity limitations in the primary screening assay, driving a strategic shift to a secondary mechanistic assay for accurate efficacy determination and candidate nomination by the targeted deadline.• Compiled… Show more Immunology Program• Developed and optimized a cellular reporter-based on-target mechanistic assay that could detect bioactivity from fungal crude extracts. Delivered consistent, high-quality, reproducible cell data, aiding in the med-chem team's SAR strategy.• Identified sensitivity limitations in the primary screening assay, driving a strategic shift to a secondary mechanistic assay for accurate efficacy determination and candidate nomination by the targeted deadline.• Compiled comprehensive literature to inform and develop experimental designs for orthogonal measurements in “on-target” versus “off-target” cell lines to establish differentiation between SoC and our developmental candidates.• Developed and optimized mechanism of action studies ranging from nuclear translocation to multi-cytokine panel studies in PBMCs and whole blood for characterizing pre-candidates for nomination.• Managed in-vitro studies at CROs in India and China on an ad-hoc basis. • Routinely analyze, interpret, and present experimental data cross-functionally.Oncology Program• Developed and optimized key cellular readouts implicated in the downstream signaling pathway for our kinase inhibitor to build a screening cascade.• Designed and optimized specific assay methods to characterize the covalent mechanism of action of our internal compounds compared to SoC.Early Drug Discovery Projects• Lead biology representative to assess new target nominations with the genomics/fungal discovery group.Industrial PhD Project• Collaborated extensively across all the departments to advance my independent research project on “Cyclosporine Biosynthesis And Self-resistance In Fungi: Toward The Discovery And Development Of Improved Drug Analogs”. Show less

Greater Boston Area

• Integral part of the Biologics Discovery Research Group to develop a cutting edge method to combine insect cell and mammalian cell expression using a unique viral system• Working with novel methods for optimizing protein expression in mammalian CHO cells and insect cell based baculovirus systems to increase productivity and decrease time needed to produce proteins of interest• Developing a method to measure titer for biologics therapeutics and reagent properties as promising early… Show more • Integral part of the Biologics Discovery Research Group to develop a cutting edge method to combine insect cell and mammalian cell expression using a unique viral system• Working with novel methods for optimizing protein expression in mammalian CHO cells and insect cell based baculovirus systems to increase productivity and decrease time needed to produce proteins of interest• Developing a method to measure titer for biologics therapeutics and reagent properties as promising early drug candidates Show less

Greater Boston Area

• Volunteered with the Drug Discovery group on campus and efficiently assisted postgraduatecandidates in conducting sterile and aseptic microbiology experiments.• Completed assigned projects prior to due date with thorough research and understanding ofthe provided topic• Followed health and safety procedures and regulations involved with sample and mediapreparation and general housekeeping for the lab

Mississauga, Ontario

• Successfully facilitated sample collection and processing, screening of study participants,and regulatory/ research documentation• Proficiently performed dosing, sampling and completion of study conduct• Accurately indexed, validated and recorded clinical data for study visits and reliablereferencing for all future studies• Prepared comprehensive study documents, including study binder and protocol review forPhase II Human Clinical Trial Visits• Effectively… Show more • Successfully facilitated sample collection and processing, screening of study participants,and regulatory/ research documentation• Proficiently performed dosing, sampling and completion of study conduct• Accurately indexed, validated and recorded clinical data for study visits and reliablereferencing for all future studies• Prepared comprehensive study documents, including study binder and protocol review forPhase II Human Clinical Trial Visits• Effectively coordinated with Quality Assurance group in the development/ revision andimplementation of Standard Operating Procedures as required. Show less

Mississauga, Canada

• As a Scanner Specialist- Analyzed data from diary cards and determined study participants to be included/excluded based on the study-specific inclusion/exclusion criteria• Assisted in maintenance and calibration of clinical, laboratory and EEC equipment• Safely and efficiently processed blood, fecal, and urine samples from study participants• Determined amount of pollen in Environmental Exposure Camber (EEC) by operating pollensamplers, staining pollen rods and examining… Show more • As a Scanner Specialist- Analyzed data from diary cards and determined study participants to be included/excluded based on the study-specific inclusion/exclusion criteria• Assisted in maintenance and calibration of clinical, laboratory and EEC equipment• Safely and efficiently processed blood, fecal, and urine samples from study participants• Determined amount of pollen in Environmental Exposure Camber (EEC) by operating pollensamplers, staining pollen rods and examining pollen rods microscopically Show less

• Conducted Bioanalytical projects, sample preparation, laboratory procedures, maintained,calibrated and operated laboratory equipment in accordance with GLP guidelines• Performed extraction and analysis of drugs/ metabolites from biological matrices, as inWatson LIMS, in compliance with GLP, SOP and regulatory guidelines• Maintained project specific laboratory documentation (e.g. laboratory logbooks/ worksheets,analytical data, project notes/forms/memos) for assigned… Show more • Conducted Bioanalytical projects, sample preparation, laboratory procedures, maintained,calibrated and operated laboratory equipment in accordance with GLP guidelines• Performed extraction and analysis of drugs/ metabolites from biological matrices, as inWatson LIMS, in compliance with GLP, SOP and regulatory guidelines• Maintained project specific laboratory documentation (e.g. laboratory logbooks/ worksheets,analytical data, project notes/forms/memos) for assigned projects and regulatory submissions Show less

Mississauga, Ontario

• Designed and conducted an experiment investigating starvation behavior in flies • Part of the Fly-food making team and involved with general housekeeping for the lab

Toronto, Canada

• Handled ice-cream sales and managed cash collections at the Center of National Exhibition, Mississauga City Centre and the Toronto Rogers Cup at Rexall Centre

Toronto, Canada

• Supervised all areas of the Food and Beverage Dept., managed a staff of 20 people and provided high end customer service• Reviewed inventory, assisted in set-ups and prepared daily cash reports

Doctor Of Philosophy - Phd, Molecular Pharmacology

Master Of Science (Ms), Biotechnology

Bachelor Of Science (Bsc), Molecular Biology