Stefan Engst Email & Phone Number

--Principal Scientist with extensive experience in drug discovery and candidate selection. Idea generator and initiator of discovery programs. Seasoned experimentalist. Advisor to biotechnology startup companies.--Dynamic leader of departmental and cross-functional (project) teams. Advises executive management and key senior staff, establishing scientific guidance and ongoing strategic planning for healthy aging, neuroprotection, oncology, metabolic and muscular disease projects.--Leads risk management strategies, initiatives of new assay technologies, data analysis and reporting tools, as well as throughput enhancing workflows. --Extensive experience with CRO partnering in crystallography, computational chemistry, as well as biochemical, cellular, and ADMEtox profiling.--Co-discovered 8 clinical candidates, including two approved drugs for multiple indications (Cabozantinib and Cobimetinib). --Expertise in NAD biology and muscular diseases, as well as oncology and inflammation. Extensive experience in mechanistic enzymology, cellular assay technologies, ADMETox, and PK/PD analysis. Prolific with a wide variety of target classes, including enzymes in NAD homeostasis, kinases, GPCRs, NHRs, and redox enzymes.--Mentored and supervised large functional and cross-functional area teams (Ph.D. and Associate level staff).

Listed skills include Drug Discovery, Drug Development, Assay Development, Biotechnology, and 21 others.