Establishing a robust method to perform ribosome footprinting in subcellular compartments, by resolving 40S and 80S footprints.Infer and validate localized principles of mRNA and protein metabolism, with a focus on stress granule compartments.Characterizing ribosomal RNP composition, highlighting the roles of associated factors in regulating translation of specific mRNA targets.Dissect the role of ribosome-associated factors, such as RNA helicases, in organoid models of neurodegeneration.

LAMP Screening Program led by DHSC at University of Leicester, UK• Operate and troubleshoot fully automated bespoke liquid handling robots (PAA). Provide technical expertise and carry out all laboratory analyses (LAMP assay), including authorising results.• Work in a Cat.2 lab according to Good Laboratory Practice (GLP), local Health and Safety policies and procedures and Quality standards (ISO 17025).• Oversee the interpretation of results and reporting to UKAS accreditation standards and maintaining DHSC KPIs. Maintain and develop SOPs and policies to ensure that the Programme meets appropriate UKAS and ISO standards.• Assist with the management of the lab (around 15 people), supervision, training and coaching of staff and maintenance of training and competence assessments records.• Quality control, operation, routine maintenance and troubleshooting of equipment and report any out of consensus results for investigation and referral of unusual results to the Clinical Director.

SARS-CoV-2 qPCR lab testing and deputy lab manager at Nationwide Pathology Lab, Lutterworth.• COVID-19 qPCR testing, and result sign out, data flux management via iCor (LIMS), troubleshooting and staff training. Ensuring compliance to quality standards, Good Laboratory Practice (GLP).• Lab automated liquid handling robots (Hamilton Star and Starlette)• Deputy manager of the lab (around 5 people).

SARS-CoV-2 qPCR analyst and deputy Lab Manager at PerkinElmer, Inc., Lighthouse Lab, Charnwood, Loughborough.• COVID-19 qPCR testing, data analysis and result sign out.• Ensuring compliance to quality standards, e.g. Good Laboratory Practice (GLP) and ISO 15189.• Review and implementation of SOP.• Troubleshooting.• Staff training.• Deputy manager of the analysis lab (around 8 people).

Post-transcriptional Control of Gene Expression, MRC Toxicology Unit, Cambridge University, UKSupervisor: Prof. Anne Willis.Projects:• Characterization of metabolism in Malignant Mesothelioma primary cell lines (cell biology and proteomics).• Characterization of protein synthesis elongation control in health and disease (cell and molecular biology, proteomics, Next Generation Sequencing).• Supervision and mentoring of junior staff involved in various projects.

Post-transcriptional Control of Gene Expression, MRC Toxicology Unit, Leicester University, UKSupervisor: Prof. Anne Willis.Projects:• Characterization of translation in Malignant Mesothelioma primary cell lines (cell biology and proteomics).• Characterization of the effects of exposure of animals to carbon nanotubes (cell and molecular biology, proteomics, sequencing).• Characterization of neuroprotective effect of Cold Shock (cell biology and proteomics).• Supervision and mentoring of junior staff involved in various projects.

Cell Growth and Molecular Histology Unit

PhD in Scienze Ambientali (Acque Interne e Agroecositemi)