Responsible for downstream process research and development. Implementation of new manufacturing processes or technologies; continuous improvement of manufacturing processes; scaling-up from pilot studies to phase I-II products.Responsible for downstream process and media preparation activities in a GMP environment. Maintenance of equipments, monitoring of storage conditions and purchasing of raw materials in accordance to GMP standards. Training of co-workers.Responsible for development, editing and revision of Standard Operating Procedures (SOPs), Technical Instructions, Risk Assessments, Batch Manufacturing Records. Accountable for activities related to Deviations, CAPA, Change Controls.

@ Department of Biochemical Sciences "A.Rossi Fanelli" with Prof. Francesca Cutruzzolà.Biofilm formation in bacterial chronic infections, metabolism of c-di-GMP in the opportunistic human pathogen Pseudomonas aeruginosa, new targets for effective anti-biofilm drugs. Characterization of a pool of strategic P. aeruginosa proteins involved in c-di-GMP metabolism, acting as diguanylate cyclases (DGCs) or phosphodiesterases (PDEs). Mentor of graduate students.

@ Department of Biology and Biotechnologies "L. Spallanzani" with Prof. Andrea Mattevi.European research project funded by Cordis FP7 (OXYGREEN, “Effective redesign of oxidative enzymes for green chemistry”). Design and construction of novel oxygenating enzymes for the production of bioactivecompounds that can be used in medicine, food and agriculture. Study of the enzymatic mechanism on Baeyer-Villiger monooxygenases (BVMOs) and N-hydroxylating monooxygenases (NMOs).Mentor of graduate students.

Ph.D. studentship @ Institute of Molecular Biology and Pathology (IBPM-CNR) with Prof. Emilia Chiancone.Structural and functional characterization of proteins involved in the cellular response to the oxydative stress (Dps) (Dr. Andrea Ilari). Structural and functional characterization of proteins involved in the calcium-dependent signal transduction (sorcin) (Dr. Gianni Colotti). Granted with a research fellowship funded by the italian National Research Counsil (CNR) (“Oligopeptide binding proteins from Archaea”).Collaborations with Prof. Alberto Boffi, Dr. Andrea Ilari and Dr. Gianni Colotti on a wide range of different projects with biotechnological and pharmacological appeal.