Principal Scientist I
CurrentProtein purificationBiophysics (ITC, TSA, enzyme kinetics)Protein crystallization
Mar 2022 - Present
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Steffen Kutter Email & Phone Number
Principal scientist I at Schrödinger, Inc.
at
Schrödinger
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@schrodinger.com
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Role
Principal scientist I at Schrödinger, Inc.
Location
Greater Boston, United States
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Who is Steffen Kutter? Overview
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Steffen Kutter is listed as Principal scientist I at Schrödinger, Inc. at Schrödinger, a with 455 employees, based in Greater Boston, United States. AeroLeads shows a work email signal at schrodinger.com and a matched LinkedIn profile for Steffen Kutter.
Steffen Kutter previously worked as Principal Scientist I at Schrödinger and Senior Scientist at Xtal Biostructures, Inc.. Steffen Kutter holds Doctor Of Philosophy (Ph.D.), Biochemistry, Magna Cum Laude (Excellent) from The Martin Luther University Of Halle-Wittenberg.
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Profile bio
About Steffen Kutter
Biochemist with more than 15-years of experience in structural biology, biophysics and assay developmentBiochemistry • Enzyme kinetic measurements, assay development and data examination (UV/VIS spectroscopy, coupled assays, fluorescence spectroscopy, stopped flow, HPLC assays, WB quantification, turbidity assays, NMR assays, small angle X-ray solution scattering based assays, catalysis within protein crystals, data processing with SigmaPlot and KinTek Explorer)• Escherichia coli based protein expression• Protein extraction from fungi and plants (Pisum sativum, Neurospora crassa, Saccharomyces cerevisiae, Kluyveromyces lactis) • Protein purification (FPLC, HPLC, affinity chromatography, ultracentrifugation, ammonium sulfate precipitation, acetone precipitation, heat denaturing)• Molecular biology (vector construction and subcloning, site-directed mutagenesis, PCR)• Electrophoresis (SDS-PAGE, IEF, native PAGE)• Immunoblotting (western blots)Biophysics and structural biology• X-ray crystallography (crystal growth, crystal modification, in-house and synchrotron data collection, data processing, refinement and structure validation, Formulatrix, CCP4, XDS, DIALS, Coot, Phenix, Pymol, collected more than 400 crystal datasets, 60 unique structures are deposited at rcsb.org or are ready to deposit)• SAXS (in-house and synchrotron data collection, data processing and data analysis, ATSAS)• AUC• ITC• NMR• EM (collaboration)• MS (collaboration)Computation• MD simulationsTeaching• Trained postdoctoral researchers, graduate students, undergraduate students and high school students in enzyme kinetics, X-ray crystallography, SAXS, AUC and protein expression and purificationLanguages• German (native proficiency)• English (full professional proficiency)• Russian (elementary proficiency)• Swedish (elementary proficiency)Google scholar profile: https://scholar.google.com/citations?user=W1nyjDEAAAAJORCID: https://orcid.org/0000-0002-0349-8161
Listed skills include X Ray Crystallography, Protein Crystallization, Crystallography, Pymol, and 27 others.
Current workplace
Steffen Kutter's current company
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Schrödinger
7 roles
Steffen Kutter work experience
A career timeline built from the work history available for this profile.
Senior Scientist
Protein purificationBiophysics (ITC, TSA, enzyme kinetics)Protein crystallizationContract research organisation
May 2019 - Feb 2022
Research Specialist
• Participated in a project to attack multiple druggable kinase sites simultaneously• Elucidated the substrate phosphorylation mechanism of Aurora A kinase and the autophosphorylation mechanism of Aurora B kinase• Busted the myth that the R-spine and a K/E salt bridge are needed for kinase activity• Discovered an intramolecular complex of the peptidyl-prolyl cis/trans isomerase Pin1• Elucidated the regulation mechanism of microtubule assembly by Tau• Developed and optimized multiple assays (e.g. SAXS binding assays of Pin1 and substrate peptides, SAXS kinetics to monitor tubulin polymerization, quantification of Aurora B autophosphorylation by using western blots, HPLC based peptide phosphorylation assays)
Jul 2009 - Apr 2019
Ph.D. Student
• Solved a 50-year-old riddle: Where is the regulatory site of yeast pyruvate decarboxylases and how is the activation signal transferred to the active site?• Developed a novel small angle X-ray solution scattering based assay to measure substrate activation of yeast pyruvate decarboxylases• Received a poster award at the International Conference on Mechanism and Physiology of Thiamine (2008) for a poster about new insights on substrate activation of yeast pyruvate decarboxylases
Oct 2004 - Apr 2009
Diploma Student
• Elucidated the influence of enzyme concentration on structure and function of yeast pyruvate decarboxylases
Nov 2003 - Sep 2004
Undergraduate Researcher
• Expressed and purified of Photosystem II from Synechocystis sp. PCC 6803
May 2003 - Jun 2003
Undergraduate Researcher
Max Planck Research Unit For Enzymology Of Protein Folding, Halle (Saale)
• Cloned human Histone H2B/g protein
Jun 2002 - Dec 2002
Team & coworkers
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Alice Hooper
Colleague at SchrödingerUnited States
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Esther Jamir
Colleague at SchrödingerHyderabad, Telangana, India
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Kisoo Park
Colleague at SchrödingerSouth Korea, Korea, Republic Of
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Muyun Lihan
Colleague at SchrödingerNew York, United States
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Brian Bolt
Colleague at SchrödingerLos Angeles, California, United States
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Laven Voth
Colleague at SchrödingerGreater Tokyo Area, Japan
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Anu Nagarajan
Colleague at SchrödingerNew York, United States
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Tsuguo Morisato
Colleague at SchrödingerTokyo, Japan
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Mildred Kamami
Colleague at SchrödingerSt Louis, Missouri, United States
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Andrew Kleinschmidt
Colleague at SchrödingerEncinitas, California, United States
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Alice Hooper
Colleague at SchrödingerUnited States
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EJ
Esther Jamir
Colleague at SchrödingerHyderabad, Telangana, India
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Kisoo Park
Colleague at SchrödingerSouth Korea, Korea, Republic Of
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Muyun Lihan
Colleague at SchrödingerNew York, United States
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BB
Brian Bolt
Colleague at SchrödingerLos Angeles, California, United States
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LV
Laven Voth
Colleague at SchrödingerGreater Tokyo Area, Japan
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Anu Nagarajan
Colleague at SchrödingerNew York, United States
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Tsuguo Morisato
Colleague at SchrödingerTokyo, Japan
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Mildred Kamami
Colleague at SchrödingerSt Louis, Missouri, United States
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Andrew Kleinschmidt
Colleague at SchrödingerEncinitas, California, United States
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2 education records
Steffen Kutter education
Doctor Of Philosophy (Ph.D.), Biochemistry, Magna Cum Laude (Excellent)
Diplom Biochemiker (= Master Of Science), Biochemistry, Thesis: 1.5 (Excellent) Overall: 1.8 (Good)
FAQ
Frequently asked questions about Steffen Kutter
Quick answers generated from the profile data available on this page.
What company does Steffen Kutter work for?
Steffen Kutter works for Schrödinger.
What is Steffen Kutter's role at Schrödinger?
Steffen Kutter is listed as Principal scientist I at Schrödinger, Inc. at Schrödinger.
What is Steffen Kutter's email address?
AeroLeads has found 1 work email signal at @schrodinger.com for Steffen Kutter at Schrödinger.
Where is Steffen Kutter based?
Steffen Kutter is based in Greater Boston, United States while working with Schrödinger.
What companies has Steffen Kutter worked for?
Steffen Kutter has worked for Schrödinger, Xtal Biostructures, Inc., Brandeis University / Hhmi, The Martin Luther University Of Halle-Wittenberg, and Umeå University.
Who are Steffen Kutter's colleagues at Schrödinger?
Steffen Kutter's colleagues at Schrödinger include Alice Hooper, Esther Jamir, Kisoo Park, Muyun Lihan, and Brian Bolt.
How can I contact Steffen Kutter?
You can use AeroLeads to view verified contact signals for Steffen Kutter at Schrödinger, including work email, phone, and LinkedIn data when available.
What schools did Steffen Kutter attend?
Steffen Kutter holds Doctor Of Philosophy (Ph.D.), Biochemistry, Magna Cum Laude (Excellent) from The Martin Luther University Of Halle-Wittenberg.
What skills is Steffen Kutter known for?
Steffen Kutter is listed with skills including X Ray Crystallography, Protein Crystallization, Crystallography, Pymol, Protein Structure, Small Angle X Ray Scattering, Saxs, and Enzyme Assays.
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