• Built pharmacostatistical models to support population pharmacokinetic/pharmacodynamic and exposure-response analyses. Skilled in time-to-event and discrete/continuous-time markov models.• Participated in cross-functional project teams to provide scientific input for dose selection for early and late-stage clinical programs (preclinical/first-in-human IND, BLA/NDA, sNDA, post-market)• Provided modeling support for programs across multiple therapeutic areas (oncology, cardiometabolic, and inflammation) and modalities (siRNA, small molecule, bispecific T-cell engagers, monocolonal antibodies)• Conducted population pharmacokinetic analysis supporting BLA submission and accelerated approval of tarlatamab, a first-in-class bispecific t-cell engager for solid tumors

• Provided PK/PD support and guidance to clinical stage project teams• Conducted PK/PD analyses and provides PKPD input for regulatory submissions• Developed population pharmacokinetic models for liver targeted therapies• Conducted concentration - QT analyses for siRNA therapies• Designed and developed a clinical trial simulation ShinyApp for population PK/PD simulation of liver targeted therapies

• Engineered layer-by-layer nanoparticle technology for targeted delivery to high grade serous ovarian cancer• Experience with siRNA loading and encapsulation, formulation of polymeric and lipid-based nanoparticles• Identified and characterized key physico-chemical relationships between nanoparticle lipid composition, mechanical properties, and in vivo pharmacokinetics and tumor accumulation • Identified optimal nanoparticle mechanical properties for efficient intracellular delivery to HGSOC• Collaborated on a team of five with Joan Brugge, Ph.D. (Harvard Medical School) to deliver a translational triple combination targeted nanoparticle therapy to patient-derived models of high grade serous ovarian cancer• Screened over 130 formulation conditions and utilized design of experiments to identify optimal synthesis conditions for stable small molecule drug encapsulation, maximal loading and high encapsulation efficiency. • Conducted nanoparticle stability studies and characterized drug release kinetics • Generated in vitro dose-response curves, analyzed drug synergy, and developed protocols for high-throughput screening• Synthesized fluorescent nanoparticles and carried out in vivo imaging and biodistribution studies• Designed and carried out dose-escalation experiments to determine maximum tolerated dose for pre-clinical animal studies. Assessed safety and toxicity profile of drug candidates• Designed and carried out survival studies in pre-clinical cancer models• Carried out immunofluorescence / immunohistochemistry staining, imaging and analysis of tumor and organ tissue sections

• Led and designed fellowship and graduate application assistance workshops for underrepresented minorities.• Coached graduate students and postdocs on manuscript writing, career materials, fellowships and grants.

• Led a team of five to co-author a featured article for the first publication of the MIT Science Policy Review. SPR seeks to enhance scientific understanding of policy makers and the general public.

• Led an eleven-member executive board. Oversaw planning and execution of two annual conferences and an orientation event reaching 600+ graduate students. • Overhauled organization’s branding and diversity efforts.

• Developed exam questions, homework problems, solution keys, and exam review material• Hosted office hours and managed online Q&A platform.

• Developed a biochemical simulator application in Python. This modeling tool enables chemists to predict local in vivo drug clearance kinetics• Designed tool to build and solve systems of ODEs using minimal user input. • Self-taught Python language

• Researched technologies for clean gas production and generated cost-benefit analyses (Perth, AU)• Developed an Excel VBA application to forecast faults in plant power generation (Karratha, AU)

• Managed a team of three that optimized operations in GMP vaccine production and resolved issues with flow measurement (Brinny, Ireland)• Worked with plant operations and contractors to conduct a root cause analysis and identify issues in the plant steam system. Developed simulations to forecast and mitigate future vulnerabilities (Carlow, Ireland)

• Developed methods to determine the effect of silver nanoparticles on the environment.• Characterized the effect of natural organic matter and salinity on the flocculation of silver nanoparticles

• Designed a VBA application to manage dry ice supply chain and estimate supply chain demand• Developed a network model using LogicNet that will allow Praxair to analyze and manage dry ice supply chain market in California• Managed portal and accounts for Praxair PDI cylinder delivery forecasting software.• Created engineering memorandums and manuals for various optimization tools.

• Published paper on effect of proplylene oxide linkers in branched amphiphilic polymers on surfactant solubility and thermodynamics

• Tutored gifted seventh grade students in operational systems, logic, number theory, probability and statistics

• Published paper on the film-formation of composite poly(methyl methacrylate) poly(butyl acrylate) (PMMA-PBA) hard shell-soft core particles