Stephanie Threatt, Phd

Stephanie Threatt, Phd Email and Phone Number

Senior Scientist @ Gilead Sciences
Pasadena, CA, US
Stephanie Threatt, Phd's Location
Pasadena, California, United States, United States
Stephanie Threatt, Phd's Contact Details

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Stephanie Threatt, Phd personal email

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About Stephanie Threatt, Phd

Stephanie Threatt PhD is a motivated, skilled and innovative research professional with exceptional communication and organizational skills. She attended Harvard College, where she graduated Cum Laude with a BA in Chemistry in 2014. She has aimed to further her knowledge related to chemistry and biochemistry by conducting research at various institutions, including UNC Charlotte, UCSF, Harvard University, and Massachusetts General Hospital (MGH). She completed her doctoral degree in Biochemistry and Molecular Biophysics in 2020 at the California Institute of Technology. Her PhD was completed with Professor Jacqueline Barton and focused on the development and execution of in vivo assessments of DNA-binding rhodium compounds that act as targeted chemotherapeutics. As a Howard Hughes Medical Institute Postdoctoral Scholar at Caltech, she employed computational chemistry techniques to study the chemical mechanism employed by the nitrogenase enzyme to convert atmospheric nitrogen into the bioavailable form of ammonia. Currently, Stephanie is a Formulation and Process Development research scientist at Gilead Sciences, where she works in a cross-functional capacity to advance the development of novel therapeutics through the use of biopharmaceutical, chemistry, and formulation science research techniques.

Stephanie Threatt, Phd's Current Company Details
Gilead Sciences

Gilead Sciences

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Senior Scientist
Pasadena, CA, US
Website:
gilead.com
Employees:
14647
Stephanie Threatt, Phd Work Experience Details
  • Gilead Sciences
    Senior Scientist
    Gilead Sciences
    Pasadena, Ca, Us
  • Gilead Sciences
    Research Scientist
    Gilead Sciences Mar 2023 - Present
    Foster City, California, United States
  • Howard Hughes Medical Institute
    Postdoctoral Scholar
    Howard Hughes Medical Institute Oct 2020 - Mar 2023
    Pasadena, California, United States
    Implementing computational chemistry methods, such as density functional theory (DFT) calculations, to elucidate dynamics and chemical bonding within the Fe7MoS9C nitrogenase active site. This work furthers efforts to understand the chemical mechanism of biological nitrogen fixation. Also, utilizing structural biology techniques, such as cryoEM and X-ray crystallography, to determine high-resolution structures of the nitrogenase iron (Fe)- protein. The resulting three-dimensional structures… Show more Implementing computational chemistry methods, such as density functional theory (DFT) calculations, to elucidate dynamics and chemical bonding within the Fe7MoS9C nitrogenase active site. This work furthers efforts to understand the chemical mechanism of biological nitrogen fixation. Also, utilizing structural biology techniques, such as cryoEM and X-ray crystallography, to determine high-resolution structures of the nitrogenase iron (Fe)- protein. The resulting three-dimensional structures will be employed to probe various steps in the enzyme’s catalytic process, including nucleotide (MgATP) binding and hydrolysis, which are essential for the conversion of dinitrogen to ammonia. Show less
  • City Of Hope Comprehensive Cancer Center
    Research Intern
    City Of Hope Comprehensive Cancer Center Sep 2017 - Oct 2020
    Duarte, Ca
    Worked with Dr. Tim Synold and Dr. Jun Wu to conduct pre-clinical assessment of a targeted chemotherapeutic. This involved organizing with various research departments across City of Hope, including medical oncology and veterinary pathology, which allowed us to investigate the anti-cancer properties of a rhodium compound called metalloinsertor Rh-PPO. Trained by City of Hope personnel in rodent handling, restraint and biomethodology, aseptic surgery and anesthesia techniques, as well as rodent… Show more Worked with Dr. Tim Synold and Dr. Jun Wu to conduct pre-clinical assessment of a targeted chemotherapeutic. This involved organizing with various research departments across City of Hope, including medical oncology and veterinary pathology, which allowed us to investigate the anti-cancer properties of a rhodium compound called metalloinsertor Rh-PPO. Trained by City of Hope personnel in rodent handling, restraint and biomethodology, aseptic surgery and anesthesia techniques, as well as rodent survival surgery and performance of necropsies on male and female mice. Show less
  • Caltech
    Graduate Student
    Caltech Sep 2014 - Jun 2020
    Pasadena, Ca
    As a doctoral candidate in Prof. Jacqueline Barton's lab, I performed pre-clinical pharmacokinetic and efficacy assessments of rhodium metalloinsertor Rh-PPO within mouse models, as well as designed and synthesized metalloinsertor-based antibody drug conjugates and liposomal formulations in order to improve the selective toxicity of metalloinsertor drugs. Additionally, I have investigated the cellular mechanism for rhodium metalloinsertor toxicity using biochemical techniques in collaboration… Show more As a doctoral candidate in Prof. Jacqueline Barton's lab, I performed pre-clinical pharmacokinetic and efficacy assessments of rhodium metalloinsertor Rh-PPO within mouse models, as well as designed and synthesized metalloinsertor-based antibody drug conjugates and liposomal formulations in order to improve the selective toxicity of metalloinsertor drugs. Additionally, I have investigated the cellular mechanism for rhodium metalloinsertor toxicity using biochemical techniques in collaboration with Amgen. Lastly, I have analyzed metalloinsertor binding to DNA using structural techniques, including X-ray crystallography and microcrystal electron diffraction (microED). Show less
  • Massachusetts General Hospital
    Summer Research Intern
    Massachusetts General Hospital Jan 2013 - May 2014
    Greater Boston Area
    Conducted research in Dr. Jacob Hooker's lab that specifically focused on PET medical imaging. This work included synthesis of radiolabeled molecules and PET studies specific for certain diseases and disorders. My project focused on the developing a new method for radiolabeling amino acids and proteins using the commonly synthesized radiotracer FDG.
  • Harvard University
    Student
    Harvard University Aug 2010 - May 2014
    Cambridge, Massachusetts
    I was an undergraduate at Harvard College, and I received a B.A. chemistry degree cum laude in 2014.
  • Ucsf
    Amgen Scholar
    Ucsf Jun 2012 - Aug 2012
    San Francisco Bay Area
    As an Amgen Scholar, I conducted biochemistry research in Dr. Natalia Jura's lab at UCSF. This research was specific to Epidermal Growth Factor Receptors (EGFRs). I worked on a project with Dr. Bettina van Lengerich to cause light dependent formation of heterodimeric Epidermal Growth Factor Receptor pairs, which would allow the signaling cascades associated to specific heterodimeric EGFR pairs to be better analyzed and understood.
  • Unc Charlotte
    Summer Research Intern
    Unc Charlotte Jun 2011 - Aug 2011
    Charlotte, North Carolina Area
    In the summer of 2011, I worked with Dr. Jun-Tao Guo of the Bioinformatics department at UNC Charlotte. I used computational techniques to research the amino acid interactions between proteins and DNA that were responsible for specific and non-specific binding.

Stephanie Threatt, Phd Education Details

Frequently Asked Questions about Stephanie Threatt, Phd

What company does Stephanie Threatt, Phd work for?

Stephanie Threatt, Phd works for Gilead Sciences

What is Stephanie Threatt, Phd's role at the current company?

Stephanie Threatt, Phd's current role is Senior Scientist.

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What schools did Stephanie Threatt, Phd attend?

Stephanie Threatt, Phd attended Caltech, Harvard University.

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Stephanie Threatt, Phd's colleagues are Winnie Pl Yeung, Julia M Smith, Brandon Mckenzie, Quincy Karp, Ms, Elizabeth Krysa, Leticia Oliveira, William Barchuk, M.d..

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