I am a computational structural biologist interested in understanding how protein dynamics impact function. My work uses computational algorithms to model more of the existing conformational ensemble but is often not modeled in structural biology experimental data. My work uses the improved ensemble modeling to explore entropy’s role in biological function.We are investigating the role of entropy in both substrate recognition and catalysis, aiming to provide a comprehensive mechanistic insight into enzymatic function. We hope this will revolutionize our understanding of how substrate chemistry and genetic perturbations influence the thermodynamics of substrate binding and catalysis, potentially heralding a new era in targeted ligand and protein engineering.