As a contractor for a major pharmaceutical company, I led an automated synthesis team preparing thousands of novel compounds annually while troubleshooting a vast array of challenges including synthetic, instrumental, and robotic issues. I maintain productive collaborative relationships with scientists and engineers across many disciplines and around the globe. In a previous role, I designed synthetic routes for challenging, novel pharmaceutical targets and executed their synthesis… Show more As a contractor for a major pharmaceutical company, I led an automated synthesis team preparing thousands of novel compounds annually while troubleshooting a vast array of challenges including synthetic, instrumental, and robotic issues. I maintain productive collaborative relationships with scientists and engineers across many disciplines and around the globe. In a previous role, I designed synthetic routes for challenging, novel pharmaceutical targets and executed their synthesis, purification, and characterization for biological evaluation. Show less

Designed and synthesized fluorescent probes for time-resolved Förster resonance energy transfer (TR-FRET) and fluorescence polarization (FP) assays. Improved manufacturing processes and manufactured fluorescent probes for operations group. Provided synthetic and analytical chemistry support for biochemistry, cell biology, screening services, external collaboration, custom assay development, and manufacturing groups. Recent work focused on developing novel epigenetic and kinase… Show more Designed and synthesized fluorescent probes for time-resolved Förster resonance energy transfer (TR-FRET) and fluorescence polarization (FP) assays. Improved manufacturing processes and manufactured fluorescent probes for operations group. Provided synthetic and analytical chemistry support for biochemistry, cell biology, screening services, external collaboration, custom assay development, and manufacturing groups. Recent work focused on developing novel epigenetic and kinase assays.• Designed and synthesized novel fluorescent probes for new HTS-compatible competitive binding assays for histone deacetylases (HDAC), DNA methyl transferase (DNMT), ERK, ABL, ATM, and erbb2.• Developed a scalable, reproducible synthesis for an essential chelate product.• Improved manufacturing protocols, resulting in increased flexibility and reduction of manufacturing lead times from more than 3 months to less than 3 weeks thus enabling a reduction of inventory from over 5 years to less than 2 years. Show less

As a medicinal chemist; designed, synthesized, and purified novel small molecules in the discovery of new pharmaceutical agents.• Identified novel small molecules for biological testing (utilizing structure-based drug design, iterative design, synthetic route design, synthesis, purification, characterization, and interpretation of biological data) of widely varying classes as a part of multidisciplinary teams.• Instrumental in the discovery of 6 clinical candidates for a variety of… Show more As a medicinal chemist; designed, synthesized, and purified novel small molecules in the discovery of new pharmaceutical agents.• Identified novel small molecules for biological testing (utilizing structure-based drug design, iterative design, synthetic route design, synthesis, purification, characterization, and interpretation of biological data) of widely varying classes as a part of multidisciplinary teams.• Instrumental in the discovery of 6 clinical candidates for a variety of targets including nuclear hormone receptors and kinases: - PPARγ: delivered 1 compound for development; developed additional novel series addressing several critical issues - erbB: co-inventor of recently approved VIZIMPRO (dacomitinib) to treat metastatic NSCLC - Androgen Receptor Antagonists: delivered 2 compounds for development - Estrogen Receptor Agonists: identified 1 clinical candidate - ALK5: identified 1 clinical candidate, independently developed greatly enhanced synthetic route• Developed process chemistry and delivered over 100 g of several preclinical candidates• Applied computational tools to enhance design efforts Show less

In the Pharmaceutical Products Division, medicinal chemist involved in the design, synthesis, and purification of potential new pharmaceuticals.• Designed and synthesized novel compounds of widely varying classes as a part of multidisciplinary teams.• Contributed to several projects including renin inhibitors, squalene synthase inhibitors, and farnesyl transferase inhibitors.• Developed process chemistry innovations for a clinical renin inhibitor• Identified several squalene… Show more In the Pharmaceutical Products Division, medicinal chemist involved in the design, synthesis, and purification of potential new pharmaceuticals.• Designed and synthesized novel compounds of widely varying classes as a part of multidisciplinary teams.• Contributed to several projects including renin inhibitors, squalene synthase inhibitors, and farnesyl transferase inhibitors.• Developed process chemistry innovations for a clinical renin inhibitor• Identified several squalene synthase preclinical candidates• Delivered 2 farnesyl transferase inhibitor preclinical candidates Show less

Medicinal chemist in the peptidomimetic group researching novel, non-peptide inhibitors of enzymatic targets.• Designed, synthesized, purified, and characterized novel target compounds as peptidomimetic HIV protease inhibitors.• Developed a novel class of irreversible inhibitors of HIV protease• Generated 5 publications/presentations

Product and process support for the chemical plant.• Investigated new opportunities for an underutilized chemical plant, including development of synthetic methodology as well as research towards new products.• Initiated research program toward novel insecticides with limited facilities and resources.