Stephen Brough Email & Phone Number

Brentford, Middlesex, Gb

A Secondment role in the Department of Data and Computational SciencesThe primary purpose of the Data Strategy and Design Manager role in the Medicine Design team is defining scientific business cases and translating them into technical requirements for data pipelines and analytics solutions. The Data Strategy and Design Manager leads the early stages of data and analytics solutions development efforts that evaluate the potential to automate the integration, preparation and provisioning of access to analysis-ready data, enabling our scientists to spend more time on interpretation and decision-making and less time on repetitive, manual data manipulation. The Data Strategy and Design Manager will also have a leadership role in activities to improve the overall data landscape for small molecule medicine design in areas such as increasing the quality of data capture in operational systems, as well as developing and embedding data standards including controlled vocabularies and defining required metadata fields to enable reuse.Orchestrated delivery, via Business, RD Tech and Vendor partnerships, of the end to end high content data flows project• Accountable for a large, multi-discipline global team (vendor and internal software developers, Subject Matter Experts, Stakeholders, Early Adopters) in the delivery of capability to address loss of content and context at every step of legacy end to end data flows• Delivering capability to enable analysis and reporting of novel data types (eg synergy screening) and AI/ML workflows

Brentford, Middlesex, Gb

In Medicine Design, in a small molecule Screening, Profiling and Mechanistic Biology departmentLed global Discovery Modernisation - Data team build a business case and detailed, robust, costed plan for radical action to enhance end to end high content data flows• Accountable for senior sponsor, stakeholder, vendor and competitor landscape engagement throughout the strategic planning and delivery process• Accountable for defining roadmaps, driving planning, identifying milestones and designing and delivering pilots to demonstrate value• Extended pivotal role in defining and driving new ways of working across the global screening businesses and delivered data upskilling through leadership of the UK Data Science Matrix Group

Brentford, Middlesex, Gb

Drove identification and implementation of changes to business processes to enhance decision making power of profiling data• Accountable for establishing and communicating best practice• Accountable for strategic planning, project leadership and delivery of platform enhancements (Columbus, ActivityBase) to enable high content screening• Developed and implemented outsourced support model and in silico Virtual eXP to identify potential hazards and reduce attrition• Initiated effort to build a coalition, a business case and detailed, robust, costed plan for radical action to enhance end to end high content data flows

Brentford, Middlesex, Gb

Managed a team supporting electrophysiological ion channel profiling • Member of the SCP-UK Leadership team, participating in strategic planning, resource allocation, portfolio management and succession planning • Led Data Analysis Best Practice team, producing the “Enabling Enhanced Decision Making” tutorial series

Brentford, Middlesex, Gb

Developing a range of functional assays (predominantly FLIPR calcium imaging platform) to support high throughput screening and structure activity relationship (SAR) campaigns targetting 7-transmembrane domain G-protein coupled receptors and ion channels across a broad therapeutic portfolio

Brentford, Middlesex, Gb

Line managed team implementing transition of functional G-protein coupled receptor portfolio (>30 assays) from FLIPR to Aequorin luminescence• Drove implementation of ActivityBase platform for data analysis, including standardization and development of best practice across six research sites

Brentford, Middlesex, Gb

Line managed a team to mature a portfolio of functional assays using FLIPR for receptor profiling across therapeutic areas in drug discovery

Brentford, Middlesex, Gb

Drove continuous improvement in data analysis and reporting practices for functional G-protein coupled receptor compound profiling using FLIPR