Stephen Mccarron, Ph.D. Email & Phone Number

Boston, Ma, Us

Boston, Ma, Us

Cambridge, Massachusetts, Us

Cambridge, Massachusetts, Us

Cambridge, Massachusetts, Us

• Plan and assist in setup of new oligonucleotide process development laboratory and establish supply chains as well as evaluate and test technologies in conjunction with internal SMEs and external vendors.• Independently plan, design and execute solid phase oligonucleotide syntheses and employ process monitoring techniques to evaluate the effectiveness of the synthesis• Identify critical process parameters and ways to improve the quality of the final product while considering the constraints of downstream GMP manufacturing• Develop modules for standard process evaluation of novel oligonucleotide sequences and bring new ideas to innovate oligonucleotide synthesis applicable to GMP manufacture• Adopt conditions from external manufacturers and internal research for feasibility assessments. Work cross-functionally with representatives of chemistry and analytical development• Develop and optimize scalable oligonucleotide purification methods under tight timelines• Act as SME and technical resource within the technical operations team and support regulatory filings• Author technical documentation such as SOPs, method documents, training documents, batch records and reports. Generate presentation materials and present data and findings to the larger group, cross functional teams and external partners• Access the literature, regulatory/guidance, databases, and technical documents to develop strategy, work plans, and timelines for discussion with supervisors and SMEs.• Review data, documents, batch records, analytical methods/qualifications, data from external vendors and support technology transfer activities involving CROs/CMOs.

Milford, Ma, Us

-Develop processes and methods for the synthesis, purification, UF, lyophilization, and testing of new and existing oligonucleotide products.-Participates in the testing and implementation of new work processes, technologies, and procedures. Involved in product scale-up, process optimization, and validation activities.-Plan, organization, and carry out laboratory work to develop/improve processes to meet quality, cost operability, productivity, and safety objectives.-Carry out laboratory support to assist in the solution of manufacturing process issues.-Tech transfer to allow for safe and effective implementation or modification of oligonucleotide processes.-Preparation of technical development protocols, reports, and campaign summary reports.

Banjara Hills, Hyderabad, In

• Designed and executed multistep organic synthesis of key intermediates and complex active pharmaceutical ingredients (API) based on customers’ needs. • Contributed to a team of process chemists focused on rapid process research and development in support of API production; working on individual and collective projects. Ensured that these processes were safe and suitable for scale up while meeting aggressive timelines and budget goals.• Proficient in full structural characterization of organic compounds with hands-on experience with instrumentation including NMR, IR, HPLC, LC-MS, GC-MS, DSC, TGA.• Managed multiple projects producing intermediates ranging from milligram to kilogram scale. Performed stepwise scale up from small round bottom flasks to 1, 5, and 30 liter jacketed vessels. Key team member during batch record preparation, process operation, and safety review. • Communicated progress both internally and with external customers through batch record preparation, technology transfer, patent writing, and video/teleconferences. Recognized for consistently clear communication and approachability. • Initiated and rolled out MSDS and chemical inventory management system for entire company. Maintain the system to ensure GHS/hazard communication compliance. Designed and delivered operational training program.

Amherst, Massachusetts, Us

Designing and synthesizing small molecule based probes for labeling of endogenous neuronal receptors. I also work as a TA for organic chemistry lab as well as lecture courses.

Loudonville, Ny, Us

Designed and synthesized crown ether derivatives for metal ion sensing.

Doctor Of Philosophy (Phd), Chemistry

Bachelor Of Science (B.S.), Chemistry